Inhibition of lymphocyte production via thymic factors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1981-04

AUTHORS

István Blazsek

ABSTRACT

A protein fraction capable of inhibiting both in vitro and in vivo lymphocyte DNA synthesis was purified, starting from a particle-free crude water extract of calf thymus and using selective precipitations with ethanol and ammonium sulphate. The semipurified T4-P2 fraction showed a preferential inhibitory activity in rat thymocyte DNA synthesis, and to a lesser extent in bone marrow and newborn rat liver cells. Non-hemopoietic cell types proved to be insensitive to T4-P2. In addition similar mouse tissue extracts (P2 fractions from testes, kidney, liver, and lung) had no effect on the spontaneous thymocyte proliferation indicating the tissue specific presence of the bioactive factor. PHA-induced T-lymphocyte proliferation was transitorily inhibited at the late G1 and S phase of the mitotic cell cycle. Also, this fraction proved to be active in decreasing the3H-thymidine incorporation into the thymus and spleen DNA time dependently after a single in vivo administration. A further purification of the bioactive factor from T4-P2 fraction was achieved using preparative isoelectric focusing. Two pH range proteins were found to be inhibitory in the short-term thymocyte assay system: pI 5.9 fraction inhibited the3H-thymidine incorporation into DNA by 80% at 10–20Μg per ml concentration. In contrast pI 4.3 fraction caused a lesser inhibitory effect. On a Sephadex G-100 column, under physiological ionicstrength and oxidative conditions pI 5.9 fraction was separated into a high and a low molecular weight inhibitory activity. The possible involvement of pI 5.9 factors and the thymosine like pI 4.3 factor in immune regulation is discussed. More... »

PAGES

235-248

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00996753

DOI

http://dx.doi.org/10.1007/bf00996753

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003260272

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6971667


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0305", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Organic Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cattle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydrogen-Ion Concentration", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Weight", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thymus Gland", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "MTA Institute of Experimental Medicine", 
          "id": "https://www.grid.ac/institutes/grid.419012.f", 
          "name": [
            "Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony utca 43, H-1083, Budapest, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blazsek", 
        "givenName": "Istv\u00e1n", 
        "id": "sg:person.056535721.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.056535721.96"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.75.5.2130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003162075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1975.tb29063.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009515822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01969564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009802874", 
          "https://doi.org/10.1007/bf01969564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01969564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009802874", 
          "https://doi.org/10.1007/bf01969564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3181/00379727-100-24522", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009979092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3181/00379727-100-24522", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009979092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/277154b0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016920232", 
          "https://doi.org/10.1038/277154b0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0047-6374(76)90008-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021231578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0047-6374(76)90008-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021231578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-4827(64)81025-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021411215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj0620315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023369885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj0620315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023369885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1976.tb03590.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027122331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0008-8749(76)90167-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027887411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4827(77)90159-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029197068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/277177a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030164299", 
          "https://doi.org/10.1038/277177a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.bi.45.070176.002531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034657586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4827(75)90452-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034667921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/274804a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035313077", 
          "https://doi.org/10.1038/274804a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2184.1979.tb00166.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042094623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-4157(74)90010-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043417808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-4157(74)90010-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043417808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/267623a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046115172", 
          "https://doi.org/10.1038/267623a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2184.1975.tb01235.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047211734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02615905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048877662", 
          "https://doi.org/10.1007/bf02615905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02615905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048877662", 
          "https://doi.org/10.1007/bf02615905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1975.tb29071.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049606450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2184.1978.tb00894.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050988018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01469129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051416985", 
          "https://doi.org/10.1007/bf01469129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01469129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051416985", 
          "https://doi.org/10.1007/bf01469129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-4165(76)90262-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053626135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-4165(76)90262-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053626135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075822792", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076585236", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079683682", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080153846", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080173642", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080240502", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080446759", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1981-04", 
    "datePublishedReg": "1981-04-01", 
    "description": "A protein fraction capable of inhibiting both in vitro and in vivo lymphocyte DNA synthesis was purified, starting from a particle-free crude water extract of calf thymus and using selective precipitations with ethanol and ammonium sulphate. The semipurified T4-P2 fraction showed a preferential inhibitory activity in rat thymocyte DNA synthesis, and to a lesser extent in bone marrow and newborn rat liver cells. Non-hemopoietic cell types proved to be insensitive to T4-P2. In addition similar mouse tissue extracts (P2 fractions from testes, kidney, liver, and lung) had no effect on the spontaneous thymocyte proliferation indicating the tissue specific presence of the bioactive factor. PHA-induced T-lymphocyte proliferation was transitorily inhibited at the late G1 and S phase of the mitotic cell cycle. Also, this fraction proved to be active in decreasing the3H-thymidine incorporation into the thymus and spleen DNA time dependently after a single in vivo administration. A further purification of the bioactive factor from T4-P2 fraction was achieved using preparative isoelectric focusing. Two pH range proteins were found to be inhibitory in the short-term thymocyte assay system: pI 5.9 fraction inhibited the3H-thymidine incorporation into DNA by 80% at 10\u201320\u039cg per ml concentration. In contrast pI 4.3 fraction caused a lesser inhibitory effect. On a Sephadex G-100 column, under physiological ionicstrength and oxidative conditions pI 5.9 fraction was separated into a high and a low molecular weight inhibitory activity. The possible involvement of pI 5.9 factors and the thymosine like pI 4.3 factor in immune regulation is discussed.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00996753", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1009149", 
        "issn": [
          "0939-5555", 
          "1432-0584"
        ], 
        "name": "Annals of Hematology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "42"
      }
    ], 
    "name": "Inhibition of lymphocyte production via thymic factors", 
    "pagination": "235-248", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0f877fc6b64cc0aae3be4248761d8ba94023f11ff3fe74aa19e73d4bd35aa56b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "6971667"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0173401"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00996753"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003260272"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00996753", 
      "https://app.dimensions.ai/details/publication/pub.1003260272"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000479.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF00996753"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00996753'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00996753'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00996753'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00996753'


 

This table displays all metadata directly associated to this object as RDF triples.

194 TRIPLES      21 PREDICATES      68 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00996753 schema:about N1084d313f4aa4788aea422b1960ace43
2 N1aba348a2cb3499eb5193bdf85cdf40f
3 N294f54c0f3544c88853426d8b78a0298
4 N3ba936c8538c4a399d60d7a37808b95c
5 N5079b172743840e2afc28e2891611d5e
6 Na67fe203f66d448095320d9b77b2b1d5
7 Nf35c34d2ae124bbca4ddd7b55ac6c9b1
8 Nf897c247615e44bfb920c2b95213309b
9 anzsrc-for:03
10 anzsrc-for:0305
11 schema:author N88b193b3427847cbb30d392e8822d6b9
12 schema:citation sg:pub.10.1007/bf01469129
13 sg:pub.10.1007/bf01969564
14 sg:pub.10.1007/bf02615905
15 sg:pub.10.1038/267623a0
16 sg:pub.10.1038/274804a0
17 sg:pub.10.1038/277154b0
18 sg:pub.10.1038/277177a0
19 https://app.dimensions.ai/details/publication/pub.1075822792
20 https://app.dimensions.ai/details/publication/pub.1076585236
21 https://app.dimensions.ai/details/publication/pub.1079683682
22 https://app.dimensions.ai/details/publication/pub.1080153846
23 https://app.dimensions.ai/details/publication/pub.1080173642
24 https://app.dimensions.ai/details/publication/pub.1080240502
25 https://app.dimensions.ai/details/publication/pub.1080446759
26 https://doi.org/10.1016/0008-8749(76)90167-2
27 https://doi.org/10.1016/0014-4827(75)90452-8
28 https://doi.org/10.1016/0014-4827(77)90159-8
29 https://doi.org/10.1016/0047-6374(76)90008-7
30 https://doi.org/10.1016/0304-4157(74)90010-0
31 https://doi.org/10.1016/0304-4165(76)90262-2
32 https://doi.org/10.1016/s0014-4827(64)81025-9
33 https://doi.org/10.1042/bj0620315
34 https://doi.org/10.1073/pnas.75.5.2130
35 https://doi.org/10.1111/j.1365-2141.1976.tb03590.x
36 https://doi.org/10.1111/j.1365-2184.1975.tb01235.x
37 https://doi.org/10.1111/j.1365-2184.1978.tb00894.x
38 https://doi.org/10.1111/j.1365-2184.1979.tb00166.x
39 https://doi.org/10.1111/j.1749-6632.1975.tb29063.x
40 https://doi.org/10.1111/j.1749-6632.1975.tb29071.x
41 https://doi.org/10.1146/annurev.bi.45.070176.002531
42 https://doi.org/10.3181/00379727-100-24522
43 schema:datePublished 1981-04
44 schema:datePublishedReg 1981-04-01
45 schema:description A protein fraction capable of inhibiting both in vitro and in vivo lymphocyte DNA synthesis was purified, starting from a particle-free crude water extract of calf thymus and using selective precipitations with ethanol and ammonium sulphate. The semipurified T4-P2 fraction showed a preferential inhibitory activity in rat thymocyte DNA synthesis, and to a lesser extent in bone marrow and newborn rat liver cells. Non-hemopoietic cell types proved to be insensitive to T4-P2. In addition similar mouse tissue extracts (P2 fractions from testes, kidney, liver, and lung) had no effect on the spontaneous thymocyte proliferation indicating the tissue specific presence of the bioactive factor. PHA-induced T-lymphocyte proliferation was transitorily inhibited at the late G1 and S phase of the mitotic cell cycle. Also, this fraction proved to be active in decreasing the3H-thymidine incorporation into the thymus and spleen DNA time dependently after a single in vivo administration. A further purification of the bioactive factor from T4-P2 fraction was achieved using preparative isoelectric focusing. Two pH range proteins were found to be inhibitory in the short-term thymocyte assay system: pI 5.9 fraction inhibited the3H-thymidine incorporation into DNA by 80% at 10–20Μg per ml concentration. In contrast pI 4.3 fraction caused a lesser inhibitory effect. On a Sephadex G-100 column, under physiological ionicstrength and oxidative conditions pI 5.9 fraction was separated into a high and a low molecular weight inhibitory activity. The possible involvement of pI 5.9 factors and the thymosine like pI 4.3 factor in immune regulation is discussed.
46 schema:genre research_article
47 schema:inLanguage en
48 schema:isAccessibleForFree false
49 schema:isPartOf N93c259da404c4f8880b7c050a3dd3fc2
50 Ne22e5b285e2b474bac121a5455014dba
51 sg:journal.1009149
52 schema:name Inhibition of lymphocyte production via thymic factors
53 schema:pagination 235-248
54 schema:productId N0ba49e991a3441978c2495ec7e818f21
55 N465b745bbe8341209a5b626a704b3d7e
56 N5f2c57bcca114ff3a74ae7f008676b4e
57 N777ed54907804eb6a614791a6b7ba36e
58 N84d06b8858d04a3291be799c745847ff
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003260272
60 https://doi.org/10.1007/bf00996753
61 schema:sdDatePublished 2019-04-10T21:29
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher Nb9237f64927d4af68a8b12a83fea296a
64 schema:url http://link.springer.com/10.1007/BF00996753
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N0ba49e991a3441978c2495ec7e818f21 schema:name doi
69 schema:value 10.1007/bf00996753
70 rdf:type schema:PropertyValue
71 N1084d313f4aa4788aea422b1960ace43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Cattle
73 rdf:type schema:DefinedTerm
74 N1aba348a2cb3499eb5193bdf85cdf40f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Animals
76 rdf:type schema:DefinedTerm
77 N294f54c0f3544c88853426d8b78a0298 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Rats
79 rdf:type schema:DefinedTerm
80 N3ba936c8538c4a399d60d7a37808b95c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Molecular Weight
82 rdf:type schema:DefinedTerm
83 N465b745bbe8341209a5b626a704b3d7e schema:name dimensions_id
84 schema:value pub.1003260272
85 rdf:type schema:PropertyValue
86 N5079b172743840e2afc28e2891611d5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name T-Lymphocytes
88 rdf:type schema:DefinedTerm
89 N5f2c57bcca114ff3a74ae7f008676b4e schema:name readcube_id
90 schema:value 0f877fc6b64cc0aae3be4248761d8ba94023f11ff3fe74aa19e73d4bd35aa56b
91 rdf:type schema:PropertyValue
92 N777ed54907804eb6a614791a6b7ba36e schema:name nlm_unique_id
93 schema:value 0173401
94 rdf:type schema:PropertyValue
95 N84d06b8858d04a3291be799c745847ff schema:name pubmed_id
96 schema:value 6971667
97 rdf:type schema:PropertyValue
98 N88b193b3427847cbb30d392e8822d6b9 rdf:first sg:person.056535721.96
99 rdf:rest rdf:nil
100 N93c259da404c4f8880b7c050a3dd3fc2 schema:volumeNumber 42
101 rdf:type schema:PublicationVolume
102 Na67fe203f66d448095320d9b77b2b1d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Hydrogen-Ion Concentration
104 rdf:type schema:DefinedTerm
105 Nb9237f64927d4af68a8b12a83fea296a schema:name Springer Nature - SN SciGraph project
106 rdf:type schema:Organization
107 Ne22e5b285e2b474bac121a5455014dba schema:issueNumber 4
108 rdf:type schema:PublicationIssue
109 Nf35c34d2ae124bbca4ddd7b55ac6c9b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Thymus Gland
111 rdf:type schema:DefinedTerm
112 Nf897c247615e44bfb920c2b95213309b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Lymphocyte Activation
114 rdf:type schema:DefinedTerm
115 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
116 schema:name Chemical Sciences
117 rdf:type schema:DefinedTerm
118 anzsrc-for:0305 schema:inDefinedTermSet anzsrc-for:
119 schema:name Organic Chemistry
120 rdf:type schema:DefinedTerm
121 sg:journal.1009149 schema:issn 0939-5555
122 1432-0584
123 schema:name Annals of Hematology
124 rdf:type schema:Periodical
125 sg:person.056535721.96 schema:affiliation https://www.grid.ac/institutes/grid.419012.f
126 schema:familyName Blazsek
127 schema:givenName István
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.056535721.96
129 rdf:type schema:Person
130 sg:pub.10.1007/bf01469129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051416985
131 https://doi.org/10.1007/bf01469129
132 rdf:type schema:CreativeWork
133 sg:pub.10.1007/bf01969564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009802874
134 https://doi.org/10.1007/bf01969564
135 rdf:type schema:CreativeWork
136 sg:pub.10.1007/bf02615905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048877662
137 https://doi.org/10.1007/bf02615905
138 rdf:type schema:CreativeWork
139 sg:pub.10.1038/267623a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046115172
140 https://doi.org/10.1038/267623a0
141 rdf:type schema:CreativeWork
142 sg:pub.10.1038/274804a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035313077
143 https://doi.org/10.1038/274804a0
144 rdf:type schema:CreativeWork
145 sg:pub.10.1038/277154b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016920232
146 https://doi.org/10.1038/277154b0
147 rdf:type schema:CreativeWork
148 sg:pub.10.1038/277177a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030164299
149 https://doi.org/10.1038/277177a0
150 rdf:type schema:CreativeWork
151 https://app.dimensions.ai/details/publication/pub.1075822792 schema:CreativeWork
152 https://app.dimensions.ai/details/publication/pub.1076585236 schema:CreativeWork
153 https://app.dimensions.ai/details/publication/pub.1079683682 schema:CreativeWork
154 https://app.dimensions.ai/details/publication/pub.1080153846 schema:CreativeWork
155 https://app.dimensions.ai/details/publication/pub.1080173642 schema:CreativeWork
156 https://app.dimensions.ai/details/publication/pub.1080240502 schema:CreativeWork
157 https://app.dimensions.ai/details/publication/pub.1080446759 schema:CreativeWork
158 https://doi.org/10.1016/0008-8749(76)90167-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027887411
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1016/0014-4827(75)90452-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034667921
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/0014-4827(77)90159-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029197068
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/0047-6374(76)90008-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021231578
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/0304-4157(74)90010-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043417808
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/0304-4165(76)90262-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053626135
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/s0014-4827(64)81025-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021411215
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1042/bj0620315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023369885
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1073/pnas.75.5.2130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003162075
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1111/j.1365-2141.1976.tb03590.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027122331
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1111/j.1365-2184.1975.tb01235.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047211734
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1111/j.1365-2184.1978.tb00894.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050988018
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1111/j.1365-2184.1979.tb00166.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042094623
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1111/j.1749-6632.1975.tb29063.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009515822
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1111/j.1749-6632.1975.tb29071.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049606450
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1146/annurev.bi.45.070176.002531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034657586
189 rdf:type schema:CreativeWork
190 https://doi.org/10.3181/00379727-100-24522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009979092
191 rdf:type schema:CreativeWork
192 https://www.grid.ac/institutes/grid.419012.f schema:alternateName MTA Institute of Experimental Medicine
193 schema:name Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony utca 43, H-1083, Budapest, Hungary
194 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...