Effect of acetyl-l-carnitine on extracellular amino acid levels in vivo in rat brain regions View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-05

AUTHORS

E. Toth, L. G. Harsing, H. Sershen, M. T. Ramacci, A. Lajtha

ABSTRACT

Acetyl-L-carnitine (ALCAR) was found to have beneficial effects in senile patients. In recent years many of its effects on the nervous system have been examined, but its mechanism(s) of action remains to be elucidated. We previously reported that it causes release of dopamine in the striatum. In the present paper we report that ALCAR, when administered at intracerebral sites via microdialysis, stimulates the release of amino acids in a concentration-dependent and regionally heterogeneous manner. The effect was strong in the striatum and cerebellum, less so in the frontal cortex, and weak in the thalamus. Seven amino acids were measured: the increase in the level of aspartate, glutamate, and taurine was substantial, and the increase in the level of glycine, serine, threonine, alanine, and glutamine in the microdialysate was minor. The stimulatory effect of ALCAR on the release of amino acids in the striatum was inhibited by the muscarinic antagonist atropine, but was not inhibited by the nicotinic antagonist mecamylamine. The effect of ALCAR on the levels of most of the amino acids tested was independent of the presence of Ca2+ in the perfusate. These results indicate that ALCAR, when administered intracerebrally at fairly high concentrations, can affect the level and the release not only of such neurotransmitters as acetylcholine and dopamine, but also of amino acids.(ABSTRACT TRUNCATED AT 250 WORDS) More... »

PAGES

573-578

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00966933

DOI

http://dx.doi.org/10.1007/bf00966933

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041331650

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8474576


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