Development of monoamine oxidase activity and monoamine effects on glutamate release in cerebellar neurons and astrocytes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1989-10

AUTHORS

L. Hertz, L. Peng, E. Hertz, B. H. J. Juurlink, P. H. Yu

ABSTRACT

Activities of monoamine oxidase (MAO) A and B were measured during the first month of postnatal development in mouse cerebellum and in primary cultures of either cerebellar granule cells or cerebellar astrocytes, derived from 7-day-old cerebella. In addition, effects of the two monoamines, serotonin (a MAO A substrate) and phenylethylamine (a MAO B substrate) on the release of glutamate under resting conditions and in a transmitter related fashion (i.e., potassium-induced, calcium-dependent glutamate release) were studied during the same period. Both MAO A and MAO B activities increased during in vivo development (beginning around postnatal day 14) and in cultured astrocytes (during a comparable time period and to a similar extent), but remained constant at a low level in granule cells. In 4-day-old cerebellar granule cell cultures there was no potassium-induced glutamate release but serotonin as well as phenylethylamine reduced the release in both the presence and absence of excess potassium. In 8- and 12-day-old granule cell cultures and in 8- and 18-day old astrocyte cultures there was a pronounced glutamate release during superfusion with 50 mM K+. In both neurons and astrocytes this response was inhibited by 1 nM of either serotonin or phenylethylamine. In the astrocytes the inhibition was followed by an increased release of glutamate in both the presence and absence of the high potassium concentration, whereas the 8-day-old neurons showed only a slight increase in glutamate release after the withdrawal of the monoamine and only in the absence of excess potassium. The response was almost identical in 8- and 18-day-old astrocytes in spite of the marked difference in MAO activities. More... »

PAGES

1039-1046

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00965940

DOI

http://dx.doi.org/10.1007/bf00965940

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033259201

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2575232


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00965940'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00965940'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00965940'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00965940'


 

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