Monoamines and metabolites in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1989-09

AUTHORS

Marcelle Bergeron, Tomás A. Reader, Gilles Pomier Layrargues, Roger F. Butterworth

ABSTRACT

Alterations in the metabolism of monoamine neurotransmitters have been proposed to be involved in the development of the hepatic encephalopathy (HE) associated with experimental and human liver failure. In order to evaluate this hypothesis, the monoamines and some of their metabolites were measured in homogenates of caudate nucleus (CAU), prefrontal (PFCo) and frontal cortex (FCo) dissected from brains obtained at autopsy from nine cirrhotic patients who had died in hepatic coma and an equal number of control subjects, free from neurological, psychiatric and hepatic disorders, matched for age and time interval from death to freezing of autopsied brain samples. Monoamine measurements were performed by high-performance liquid chromatography with ion-pairing and electrochemical detection after a simple extraction procedure. In all three regions investigated, concentrations of dopamine (DA) were unchanged in cirrhotic patients vs controls while its metabolites, 3-methoxytyramine (3-MT) and homovanillic acid (HVA) were selectively affected i.e. 3-MT was found to be increased in CAU, while HVA levels were increased in FCo and CAU. DOPAC was also found to be unchanged in CAU. Noradrenaline (NA) levels were greatly increased in PFCo and FCo of cirrhotic patients but remained unchanged in CAU. No significant differences in the concentrations of either serotonin (5-HT) or of its precursor 5-hydroxytryptophan (5-HTP) were found in any of the three regions studied. However, 5-hydroxyindoleacetic acid (5-HIAA), the major metabolite of 5-HT, was increased in PFCo and CAU of cirrhotic patients. These findings show that selective alterations of catecholamine and 5-HT systems are involved in human HE and therefore, they may play an important role in the pathogenesis of certain neurological symptoms associated with this encephalopathy. More... »

PAGES

853-859

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00964814

DOI

http://dx.doi.org/10.1007/bf00964814

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052121478

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2480534


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biogenic Monoamines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caudate Nucleus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebral Cortex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatography, High Pressure Liquid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dopamine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Frontal Lobe", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatic Encephalopathy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homovanillic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydroxyindoleacetic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Cirrhosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Norepinephrine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Serotonin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Montreal", 
          "id": "https://www.grid.ac/institutes/grid.14848.31", 
          "name": [
            "Laboratory of Neurochemistry, Andr\u00e9-Viallet Clinical Research Centre, H\u00f4pital Saint-Luc, 1058 St-Denis St., H2X 3J4, Mentr\u00e9al, Qu\u00e9bec, Canada", 
            "Centre de recherche en sciences neurologiques, University of Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bergeron", 
        "givenName": "Marcelle", 
        "id": "sg:person.0700715402.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700715402.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Montreal", 
          "id": "https://www.grid.ac/institutes/grid.14848.31", 
          "name": [
            "Centre de recherche en sciences neurologiques, University of Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reader", 
        "givenName": "Tom\u00e1s A.", 
        "id": "sg:person.01312227613.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312227613.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Luc", 
          "id": "https://www.grid.ac/institutes/grid.414407.2", 
          "name": [
            "Liver Unit, Andr\u00e9-Viallet Clinical Research Centre, H\u00f4pital Saint-Luc, 1058 St-Denis St., H2X 3J4, Mentr\u00e9al, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Layrargues", 
        "givenName": "Gilles Pomier", 
        "id": "sg:person.01103552607.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103552607.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Montreal", 
          "id": "https://www.grid.ac/institutes/grid.14848.31", 
          "name": [
            "Laboratory of Neurochemistry, Andr\u00e9-Viallet Clinical Research Centre, H\u00f4pital Saint-Luc, 1058 St-Denis St., H2X 3J4, Mentr\u00e9al, Qu\u00e9bec, Canada", 
            "Centre de recherche en sciences neurologiques, University of Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Butterworth", 
        "givenName": "Roger F.", 
        "id": "sg:person.0765176464.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765176464.29"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1136/gut.21.7.565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001552512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01248951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001981777", 
          "https://doi.org/10.1007/bf01248951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.490040407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002200956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1979.tb00350.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004241277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1476-5381.1962.tb01417.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005847987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0447.1974.tb09711.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007661368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(75)91632-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007724133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(75)91632-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007724133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4886(85)90037-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008553375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01656607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009452544", 
          "https://doi.org/10.1007/bf01656607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01656607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009452544", 
          "https://doi.org/10.1007/bf01656607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2362.1976.tb00533.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010778710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-197803000-00024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012800953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-197803000-00024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012800953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1980.tb07875.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013849911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00998476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014115209", 
          "https://doi.org/10.1007/bf00998476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01250085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015854827", 
          "https://doi.org/10.1007/bf01250085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1984.tb12789.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016209063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01250597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017616848", 
          "https://doi.org/10.1007/bf01250597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(75)90428-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019843912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(75)90428-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019843912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1975.tb03678.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022465309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000127994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023346675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(71)92048-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023473816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01249444", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027245356", 
          "https://doi.org/10.1007/bf01249444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198308000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030165236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198308000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030165236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(74)90247-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034550174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(74)90247-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034550174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0773.1965.tb00347.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035296540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0013-4694(72)90044-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041538400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0013-4694(72)90044-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041538400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.1.5907.549", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042573446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01000293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043120980", 
          "https://doi.org/10.1007/bf01000293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00971709", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043870947", 
          "https://doi.org/10.1007/bf00971709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000128452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044049647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1977.tb10678.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045000474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0197-0186(87)90070-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046657136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0197-0186(87)90070-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046657136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00999609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046949383", 
          "https://doi.org/10.1007/bf00999609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1976.tb12274.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049011464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-4347(00)83219-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049801162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2362.1985.tb00165.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051740070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01391377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052838277", 
          "https://doi.org/10.1007/bf01391377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076750128", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078851745", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/3-540-05462-6_2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080323097", 
          "https://doi.org/10.1007/3-540-05462-6_2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080465105", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081314575", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082758961", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082992067", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/acps.1980.61.s280.75", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090362644"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1989-09", 
    "datePublishedReg": "1989-09-01", 
    "description": "Alterations in the metabolism of monoamine neurotransmitters have been proposed to be involved in the development of the hepatic encephalopathy (HE) associated with experimental and human liver failure. In order to evaluate this hypothesis, the monoamines and some of their metabolites were measured in homogenates of caudate nucleus (CAU), prefrontal (PFCo) and frontal cortex (FCo) dissected from brains obtained at autopsy from nine cirrhotic patients who had died in hepatic coma and an equal number of control subjects, free from neurological, psychiatric and hepatic disorders, matched for age and time interval from death to freezing of autopsied brain samples. Monoamine measurements were performed by high-performance liquid chromatography with ion-pairing and electrochemical detection after a simple extraction procedure. In all three regions investigated, concentrations of dopamine (DA) were unchanged in cirrhotic patients vs controls while its metabolites, 3-methoxytyramine (3-MT) and homovanillic acid (HVA) were selectively affected i.e. 3-MT was found to be increased in CAU, while HVA levels were increased in FCo and CAU. DOPAC was also found to be unchanged in CAU. Noradrenaline (NA) levels were greatly increased in PFCo and FCo of cirrhotic patients but remained unchanged in CAU. No significant differences in the concentrations of either serotonin (5-HT) or of its precursor 5-hydroxytryptophan (5-HTP) were found in any of the three regions studied. However, 5-hydroxyindoleacetic acid (5-HIAA), the major metabolite of 5-HT, was increased in PFCo and CAU of cirrhotic patients. These findings show that selective alterations of catecholamine and 5-HT systems are involved in human HE and therefore, they may play an important role in the pathogenesis of certain neurological symptoms associated with this encephalopathy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00964814", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1085962", 
        "issn": [
          "0364-3190", 
          "1573-6903"
        ], 
        "name": "Neurochemical Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "Monoamines and metabolites in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy", 
    "pagination": "853-859", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f845c2dc0954b80a80d205fac10d9efde23850de13a09e9683e1de53ce3ac16c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2480534"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7613461"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00964814"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1052121478"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00964814", 
      "https://app.dimensions.ai/details/publication/pub.1052121478"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:44", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000483.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF00964814"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00964814'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00964814'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00964814'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00964814'


 

This table displays all metadata directly associated to this object as RDF triples.

295 TRIPLES      21 PREDICATES      89 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00964814 schema:about N0a90359422fa4b439b7ec79d4941e165
2 N0d320f47a52643839fff47613d118695
3 N0da42364f6ac45a29906f28c7c3afc32
4 N1c225a95acba4540ad3c9bf07f533fe9
5 N1de06902714e4c6db13347c136f6ec2e
6 N47a1be1875bb4908b980c8e619509dc7
7 N48c07b58eaad4d0fbfad22a1d16e7189
8 N573bb8fb9eac436484b4a02687bba421
9 N5f4f01fa5fd64529b2cec7e7d8c31644
10 N71c6da9c48954ad58f36e8e4128b6aa3
11 N81045504ee3d4141a27963b8c5d0d3d7
12 N90525c7f7736488f89781cd617d32c0b
13 Ne015a663d53a4c5dae1716ebb6cdfd4e
14 Ne983824a6a8b4ca99ce0c787d9867c08
15 Nf3acf8742807465aa9e463317d687634
16 Nfa8963600d3f41169a57114a04ac3bb5
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author N7bca06e420084ad69ac95a87f8699682
20 schema:citation sg:pub.10.1007/3-540-05462-6_2
21 sg:pub.10.1007/bf00971709
22 sg:pub.10.1007/bf00998476
23 sg:pub.10.1007/bf00999609
24 sg:pub.10.1007/bf01000293
25 sg:pub.10.1007/bf01248951
26 sg:pub.10.1007/bf01249444
27 sg:pub.10.1007/bf01250085
28 sg:pub.10.1007/bf01250597
29 sg:pub.10.1007/bf01391377
30 sg:pub.10.1007/bf01656607
31 https://app.dimensions.ai/details/publication/pub.1076750128
32 https://app.dimensions.ai/details/publication/pub.1078851745
33 https://app.dimensions.ai/details/publication/pub.1080465105
34 https://app.dimensions.ai/details/publication/pub.1081314575
35 https://app.dimensions.ai/details/publication/pub.1082758961
36 https://app.dimensions.ai/details/publication/pub.1082992067
37 https://doi.org/10.1002/jnr.490040407
38 https://doi.org/10.1016/0006-2952(75)90428-1
39 https://doi.org/10.1016/0006-8993(74)90247-9
40 https://doi.org/10.1016/0013-4694(72)90044-2
41 https://doi.org/10.1016/0014-4886(85)90037-8
42 https://doi.org/10.1016/0197-0186(87)90070-2
43 https://doi.org/10.1016/s0140-6736(71)92048-4
44 https://doi.org/10.1016/s0140-6736(75)91632-3
45 https://doi.org/10.1016/s0378-4347(00)83219-3
46 https://doi.org/10.1097/00000658-197803000-00024
47 https://doi.org/10.1097/00000658-198308000-00011
48 https://doi.org/10.1111/acps.1980.61.s280.75
49 https://doi.org/10.1111/j.1365-2362.1976.tb00533.x
50 https://doi.org/10.1111/j.1365-2362.1985.tb00165.x
51 https://doi.org/10.1111/j.1471-4159.1975.tb03678.x
52 https://doi.org/10.1111/j.1471-4159.1976.tb12274.x
53 https://doi.org/10.1111/j.1471-4159.1977.tb10678.x
54 https://doi.org/10.1111/j.1471-4159.1979.tb00350.x
55 https://doi.org/10.1111/j.1471-4159.1980.tb07875.x
56 https://doi.org/10.1111/j.1471-4159.1984.tb12789.x
57 https://doi.org/10.1111/j.1476-5381.1962.tb01417.x
58 https://doi.org/10.1111/j.1600-0447.1974.tb09711.x
59 https://doi.org/10.1111/j.1600-0773.1965.tb00347.x
60 https://doi.org/10.1136/bmj.1.5907.549
61 https://doi.org/10.1136/gut.21.7.565
62 https://doi.org/10.1159/000127994
63 https://doi.org/10.1159/000128452
64 schema:datePublished 1989-09
65 schema:datePublishedReg 1989-09-01
66 schema:description Alterations in the metabolism of monoamine neurotransmitters have been proposed to be involved in the development of the hepatic encephalopathy (HE) associated with experimental and human liver failure. In order to evaluate this hypothesis, the monoamines and some of their metabolites were measured in homogenates of caudate nucleus (CAU), prefrontal (PFCo) and frontal cortex (FCo) dissected from brains obtained at autopsy from nine cirrhotic patients who had died in hepatic coma and an equal number of control subjects, free from neurological, psychiatric and hepatic disorders, matched for age and time interval from death to freezing of autopsied brain samples. Monoamine measurements were performed by high-performance liquid chromatography with ion-pairing and electrochemical detection after a simple extraction procedure. In all three regions investigated, concentrations of dopamine (DA) were unchanged in cirrhotic patients vs controls while its metabolites, 3-methoxytyramine (3-MT) and homovanillic acid (HVA) were selectively affected i.e. 3-MT was found to be increased in CAU, while HVA levels were increased in FCo and CAU. DOPAC was also found to be unchanged in CAU. Noradrenaline (NA) levels were greatly increased in PFCo and FCo of cirrhotic patients but remained unchanged in CAU. No significant differences in the concentrations of either serotonin (5-HT) or of its precursor 5-hydroxytryptophan (5-HTP) were found in any of the three regions studied. However, 5-hydroxyindoleacetic acid (5-HIAA), the major metabolite of 5-HT, was increased in PFCo and CAU of cirrhotic patients. These findings show that selective alterations of catecholamine and 5-HT systems are involved in human HE and therefore, they may play an important role in the pathogenesis of certain neurological symptoms associated with this encephalopathy.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree false
70 schema:isPartOf N76024e2f06714915b557bc0a0bd913b2
71 N7ace3027356240d584c67eff1a20fea6
72 sg:journal.1085962
73 schema:name Monoamines and metabolites in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy
74 schema:pagination 853-859
75 schema:productId N2fe593bbf2654893984b62710b67f3c6
76 N30b4f23311b14d899edce5526f7ab8d7
77 N3264bc238c7c4309951796e45a340a98
78 N5bef08be253249398e610e39ba9484e1
79 Na9ced2e0baf04957a188d3cb94372f88
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052121478
81 https://doi.org/10.1007/bf00964814
82 schema:sdDatePublished 2019-04-10T15:44
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher Nfda60f953fe04b849335560c20c1e1d6
85 schema:url http://link.springer.com/10.1007/BF00964814
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N0a90359422fa4b439b7ec79d4941e165 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Biogenic Monoamines
91 rdf:type schema:DefinedTerm
92 N0d320f47a52643839fff47613d118695 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Norepinephrine
94 rdf:type schema:DefinedTerm
95 N0da42364f6ac45a29906f28c7c3afc32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Chromatography, High Pressure Liquid
97 rdf:type schema:DefinedTerm
98 N1c225a95acba4540ad3c9bf07f533fe9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Liver Cirrhosis
100 rdf:type schema:DefinedTerm
101 N1de06902714e4c6db13347c136f6ec2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Humans
103 rdf:type schema:DefinedTerm
104 N2fe593bbf2654893984b62710b67f3c6 schema:name dimensions_id
105 schema:value pub.1052121478
106 rdf:type schema:PropertyValue
107 N30b4f23311b14d899edce5526f7ab8d7 schema:name doi
108 schema:value 10.1007/bf00964814
109 rdf:type schema:PropertyValue
110 N3264bc238c7c4309951796e45a340a98 schema:name pubmed_id
111 schema:value 2480534
112 rdf:type schema:PropertyValue
113 N405df4161cdf496bacb0073f272c6ee9 rdf:first sg:person.01312227613.31
114 rdf:rest Ncb5a5a453e484e418e38cb0d9b2a56f5
115 N47a1be1875bb4908b980c8e619509dc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Middle Aged
117 rdf:type schema:DefinedTerm
118 N48c07b58eaad4d0fbfad22a1d16e7189 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Cerebral Cortex
120 rdf:type schema:DefinedTerm
121 N573bb8fb9eac436484b4a02687bba421 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Hydroxyindoleacetic Acid
123 rdf:type schema:DefinedTerm
124 N5bef08be253249398e610e39ba9484e1 schema:name readcube_id
125 schema:value f845c2dc0954b80a80d205fac10d9efde23850de13a09e9683e1de53ce3ac16c
126 rdf:type schema:PropertyValue
127 N5f4f01fa5fd64529b2cec7e7d8c31644 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Serotonin
129 rdf:type schema:DefinedTerm
130 N6f601e092af74bb288c5c18c4509e5ac rdf:first sg:person.0765176464.29
131 rdf:rest rdf:nil
132 N71c6da9c48954ad58f36e8e4128b6aa3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Homovanillic Acid
134 rdf:type schema:DefinedTerm
135 N76024e2f06714915b557bc0a0bd913b2 schema:volumeNumber 14
136 rdf:type schema:PublicationVolume
137 N7ace3027356240d584c67eff1a20fea6 schema:issueNumber 9
138 rdf:type schema:PublicationIssue
139 N7bca06e420084ad69ac95a87f8699682 rdf:first sg:person.0700715402.16
140 rdf:rest N405df4161cdf496bacb0073f272c6ee9
141 N81045504ee3d4141a27963b8c5d0d3d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Hepatic Encephalopathy
143 rdf:type schema:DefinedTerm
144 N90525c7f7736488f89781cd617d32c0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Brain
146 rdf:type schema:DefinedTerm
147 Na9ced2e0baf04957a188d3cb94372f88 schema:name nlm_unique_id
148 schema:value 7613461
149 rdf:type schema:PropertyValue
150 Ncb5a5a453e484e418e38cb0d9b2a56f5 rdf:first sg:person.01103552607.79
151 rdf:rest N6f601e092af74bb288c5c18c4509e5ac
152 Ne015a663d53a4c5dae1716ebb6cdfd4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Frontal Lobe
154 rdf:type schema:DefinedTerm
155 Ne983824a6a8b4ca99ce0c787d9867c08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Aged
157 rdf:type schema:DefinedTerm
158 Nf3acf8742807465aa9e463317d687634 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Dopamine
160 rdf:type schema:DefinedTerm
161 Nfa8963600d3f41169a57114a04ac3bb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Caudate Nucleus
163 rdf:type schema:DefinedTerm
164 Nfda60f953fe04b849335560c20c1e1d6 schema:name Springer Nature - SN SciGraph project
165 rdf:type schema:Organization
166 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
167 schema:name Medical and Health Sciences
168 rdf:type schema:DefinedTerm
169 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
170 schema:name Clinical Sciences
171 rdf:type schema:DefinedTerm
172 sg:journal.1085962 schema:issn 0364-3190
173 1573-6903
174 schema:name Neurochemical Research
175 rdf:type schema:Periodical
176 sg:person.01103552607.79 schema:affiliation https://www.grid.ac/institutes/grid.414407.2
177 schema:familyName Layrargues
178 schema:givenName Gilles Pomier
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103552607.79
180 rdf:type schema:Person
181 sg:person.01312227613.31 schema:affiliation https://www.grid.ac/institutes/grid.14848.31
182 schema:familyName Reader
183 schema:givenName Tomás A.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312227613.31
185 rdf:type schema:Person
186 sg:person.0700715402.16 schema:affiliation https://www.grid.ac/institutes/grid.14848.31
187 schema:familyName Bergeron
188 schema:givenName Marcelle
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700715402.16
190 rdf:type schema:Person
191 sg:person.0765176464.29 schema:affiliation https://www.grid.ac/institutes/grid.14848.31
192 schema:familyName Butterworth
193 schema:givenName Roger F.
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765176464.29
195 rdf:type schema:Person
196 sg:pub.10.1007/3-540-05462-6_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080323097
197 https://doi.org/10.1007/3-540-05462-6_2
198 rdf:type schema:CreativeWork
199 sg:pub.10.1007/bf00971709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043870947
200 https://doi.org/10.1007/bf00971709
201 rdf:type schema:CreativeWork
202 sg:pub.10.1007/bf00998476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014115209
203 https://doi.org/10.1007/bf00998476
204 rdf:type schema:CreativeWork
205 sg:pub.10.1007/bf00999609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046949383
206 https://doi.org/10.1007/bf00999609
207 rdf:type schema:CreativeWork
208 sg:pub.10.1007/bf01000293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043120980
209 https://doi.org/10.1007/bf01000293
210 rdf:type schema:CreativeWork
211 sg:pub.10.1007/bf01248951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001981777
212 https://doi.org/10.1007/bf01248951
213 rdf:type schema:CreativeWork
214 sg:pub.10.1007/bf01249444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027245356
215 https://doi.org/10.1007/bf01249444
216 rdf:type schema:CreativeWork
217 sg:pub.10.1007/bf01250085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015854827
218 https://doi.org/10.1007/bf01250085
219 rdf:type schema:CreativeWork
220 sg:pub.10.1007/bf01250597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017616848
221 https://doi.org/10.1007/bf01250597
222 rdf:type schema:CreativeWork
223 sg:pub.10.1007/bf01391377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052838277
224 https://doi.org/10.1007/bf01391377
225 rdf:type schema:CreativeWork
226 sg:pub.10.1007/bf01656607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009452544
227 https://doi.org/10.1007/bf01656607
228 rdf:type schema:CreativeWork
229 https://app.dimensions.ai/details/publication/pub.1076750128 schema:CreativeWork
230 https://app.dimensions.ai/details/publication/pub.1078851745 schema:CreativeWork
231 https://app.dimensions.ai/details/publication/pub.1080465105 schema:CreativeWork
232 https://app.dimensions.ai/details/publication/pub.1081314575 schema:CreativeWork
233 https://app.dimensions.ai/details/publication/pub.1082758961 schema:CreativeWork
234 https://app.dimensions.ai/details/publication/pub.1082992067 schema:CreativeWork
235 https://doi.org/10.1002/jnr.490040407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002200956
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/0006-2952(75)90428-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019843912
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/0006-8993(74)90247-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034550174
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/0013-4694(72)90044-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041538400
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/0014-4886(85)90037-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008553375
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/0197-0186(87)90070-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046657136
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/s0140-6736(71)92048-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023473816
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/s0140-6736(75)91632-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007724133
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/s0378-4347(00)83219-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049801162
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1097/00000658-197803000-00024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012800953
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1097/00000658-198308000-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030165236
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1111/acps.1980.61.s280.75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090362644
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1111/j.1365-2362.1976.tb00533.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010778710
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1111/j.1365-2362.1985.tb00165.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051740070
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1111/j.1471-4159.1975.tb03678.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022465309
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1111/j.1471-4159.1976.tb12274.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049011464
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1111/j.1471-4159.1977.tb10678.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045000474
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1111/j.1471-4159.1979.tb00350.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004241277
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1111/j.1471-4159.1980.tb07875.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013849911
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1111/j.1471-4159.1984.tb12789.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016209063
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1111/j.1476-5381.1962.tb01417.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005847987
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1111/j.1600-0447.1974.tb09711.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007661368
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1111/j.1600-0773.1965.tb00347.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035296540
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1136/bmj.1.5907.549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042573446
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1136/gut.21.7.565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001552512
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1159/000127994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023346675
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1159/000128452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044049647
288 rdf:type schema:CreativeWork
289 https://www.grid.ac/institutes/grid.14848.31 schema:alternateName University of Montreal
290 schema:name Centre de recherche en sciences neurologiques, University of Montréal, Montréal, Québec, Canada
291 Laboratory of Neurochemistry, André-Viallet Clinical Research Centre, Hôpital Saint-Luc, 1058 St-Denis St., H2X 3J4, Mentréal, Québec, Canada
292 rdf:type schema:Organization
293 https://www.grid.ac/institutes/grid.414407.2 schema:alternateName Hôpital Saint-Luc
294 schema:name Liver Unit, André-Viallet Clinical Research Centre, Hôpital Saint-Luc, 1058 St-Denis St., H2X 3J4, Mentréal, Québec, Canada
295 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...