Fluorometrische Bestimmung von “aktiviertem” Cyclophosphamid und Ifosfamid im Blut View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1979-10

AUTHORS

G. Voelcker, R. Haeglsperger, H. J. Hohorst

ABSTRACT

"Activated" N-(2-Chloroethyl)amido-oxazaphosphorines like 4-hydroxycyclophosphamide, 4-hydroperoxycyclophosphamide, 4-hydroxyifosfamide, and 4-hydroperoxyifosfamide can be determined fluorometrically by condensation of liberated acrolein with m-aminophenol yielding 7-hydroxychinolin. The method permits determination of 10(-10) mol and is specific for "activated" N-(2-Chloroethyl)amido-oxazaphosphorine metabolites which liberate acrolein under conditions of the test. Neither cyclophosphamide nor ifosfamide or other metabolites of this cytostatics interfere with the test. Blood levels of free 4-hydroxycyclophosphamide and 4-hydroxyifosfamide were determined after injection of cyclophosphamide and ifosfamide into mice. More... »

PAGES

233-240

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00964578

DOI

http://dx.doi.org/10.1007/bf00964578

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025565295

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/468886


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