Randomized trial of albendazole versus tiabendazole plus flubendazole during an outbreak of human trichinellosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-01

AUTHORS

V. Fourestié, M. E. Bougnoux, T. Ancelle, M. Liance, F. Roudot-Thoraval, H. Naga, M. Pairon-Pennachioni, A. Rauss, J. L. Lejonc

ABSTRACT

To determine the therapeutic usefulness of benzimidazoles in trichinellosis, 117 patients from a single outbreak were treated either with albendazole alone (N=59) or with a regimen including tiabendazole followed by flubendazole (N=58). The criteria of disease activity were evaluated at days 1, 7, 15, and 45. No difference was found between the two groups with regard to the evolution of myalgia, fever, fatigue, new clinical manifestations, or laboratory and serologic data. Both treatment regimens were well tolerated. In all, 30 patients of the albendazole group and 29 of the tiabendazole-flubendazole group were reevaluated 16 months later. Serology was negative in 70% of the albendazole-treated patients vs 34.5% of the tiabendazole-flubendazole-treated patients (P<0.01). The muscle biopsy examination of nine patients suggested less parasitic infection in the albendazole group. In conclusion, no difference was noted during the early therapeutic responses to the drugs used, but albendazole might be more effective than the other regimen in treating residual larval infestation estimated 16 months after the onset of the disease. More... »

PAGES

36-41

References to SciGraph publications

  • 1983. Clinical Aspects in Man in TRICHINELLA AND TRICHINOSIS
  • 1983. Chemotherapy in TRICHINELLA AND TRICHINOSIS
  • 1983. Trichinella and Trichinosis in NONE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00931188

    DOI

    http://dx.doi.org/10.1007/bf00931188

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1012458233

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3060872


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