Dopamine D2 receptor binding and cerebral glucose metabolism recover afterd-penicillamine-therapy in Wilson's disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-10

AUTHORS

G. Schlaug, H. Hefter, B. Nebeling, V. Engelbrecht, P. Weiss, G. Stöcklin, R. J. Seitz

ABSTRACT

Regional cerebral glucose metabolism (rCMRGlc) and dopamine D2 receptor binding were measured in a 31-year-old, severely affected, untreated patient with Wilson's disease of 3 years' duration using positron emission tomography and 18F-deoxyglucose and 18F-methylspiperone ([18F]MSP), respectively. There was a severe reduction of striatal and extrastriatal rCMRGlc as well as of striatal [18F]MSP accumulation rate. After 1 year of treatment with D-penicillamine, striatal and extrastriatal rCMRGlc and striatal [18F]MSP accumulation rate reached almost normal levels. It is hypothesized that recovery of motor functions due to copper trapping therapy was associated with an increase in basal ganglia activity and a re-expression or upregulation of dopamine D2 receptors. More... »

PAGES

577-584

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00920620

DOI

http://dx.doi.org/10.1007/bf00920620

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014276497

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7836960


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