Lysophosphatidylethanolamine is the antigen to which apparent antibody to phosphatidylethanolamine binds View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-07

AUTHORS

Tasneem Qamar, Azzudin E. Gharavi, Roger A. Levy, Michael D. Lockshin

ABSTRACT

Because binding of antiphospholipid antibody (aPL) to phosphatidylethanolamine (PE) is central to the definition of the antigenic epitope targeted by aPLs, we examined the binding of aPL-positive SLE sera to PE under various conditions. No serum bound to PE uncontaminated with lysophosphatidylethanolamine (IPE), but many aPL-positive sera bound to IPE-contaminated PE and to IPE coated onto an ELISA plate. Absorption studies indicated partial cross-reactivity between PE containing IPE and cardiolipin. We conclude that clinical aPLs do not bind to PE. Prior reports to the contrary most likely represent binding of aPL to PE's degradation product, IPE. More... »

PAGES

200-203

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00918652

DOI

http://dx.doi.org/10.1007/bf00918652

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013853325

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2211960


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