Phospholipid binding of antiphospholipid antibodies and placental anticoagulant protein View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1992-01

AUTHORS

Lisa R. Sammaritano, Azzudin E. Gharavi, Consolacion Soberano, Roger A. Levy, Michael D. Lockshin

ABSTRACT

We evaluated the interaction of antiphospholipid antibodies (aPL) with placental anticoagulant protein I (PAP I), a calcium-dependent phospholipid binding protein which may act as a natural anticoagulant. Clotting assays showed additive prolongation of clotting times with aPL and PAP I. ELISA and vesicle phospholipid binding studies showed PAP I inhibition of aPL binding to phospholipid but no inhibition of PAP I-phospholipid binding by aPL. aPL and PAP I interact additively in anticoagulant activity inin vitro clotting systems and compete for phospholipid in ELISA system. These data support the hypotheses that aPL and PAP I may recognize similar phospholipid epitopes and thatin vivo interaction may occur. More... »

PAGES

27-35

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00918270

DOI

http://dx.doi.org/10.1007/bf00918270

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031927962

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1372614


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