Low T-cell responsiveness to activation via CD3/TCR is a prognostic marker for acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus-1 ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-03

AUTHORS

Peter Th. A. Schellekens, Marijke Th. L. Roos, Frank de Wolf, Joep M. A. Lange, Frank Miedema

ABSTRACT

In a cohort of 300 HIV-1-infected homosexual men, studied longitudinally, the prognostic value of T-cell proliferative responses for development of AIDS was analyzed. In 15 persons we observed that, at seroconversion, T-cell reactivity to anti-CD3 monoclonal antibody (Mab) and phytohemagglutinin (PHA) was decreased to 20 and 60% of the normal values, respectively. After seroconversion, within 3 months, the response to anti-CD3 Mab and PHA returned to 60 and 80%, respectively, of the normal magnitude and declined thereafter. To investigate whether low T-cell reactivity correlated with progression to AIDS, groups of progressors and nonprogressors were compared. In individuals who progressed to AIDS, already 12 months before diagnosis, responses to anti-CD3 Mab were virtually absent, whereas at that time CD4+ cell numbers and reactivity to horse anti-human lymphocyte serum and PHA were still comparable to values observed for nonprogressors and the asymptomatic population as a whole. In a disease-free survival analysis, low anti-CD3 Mab reactivity predicted progression to AIDS. Our findings demonstrate that low T-cell responsiveness to anti-CD3 Mab is an early marker of progression toward AIDS in HIV-1 infected individuals. More... »

PAGES

121-127

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00918194

DOI

http://dx.doi.org/10.1007/bf00918194

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016517713

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2140115


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acquired Immunodeficiency Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, Differentiation, T-Lymphocyte", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD3 Complex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Predictive Value of Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Antigen, T-Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Statistics as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.7177.6", 
          "name": [
            "Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, incorporating the Laboratory of Experimental and Clinical Immunology, University of Amsterdam, Amsterdam, The Netherlands", 
            "Department of Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schellekens", 
        "givenName": "Peter Th. A.", 
        "id": "sg:person.0760130432.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760130432.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, incorporating the Laboratory of Experimental and Clinical Immunology, University of Amsterdam, Amsterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, incorporating the Laboratory of Experimental and Clinical Immunology, University of Amsterdam, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roos", 
        "givenName": "Marijke Th. L.", 
        "id": "sg:person.012150170602.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012150170602.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Virology of the Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.7177.6", 
          "name": [
            "Department of Virology of the Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Wolf", 
        "givenName": "Frank", 
        "id": "sg:person.01070144336.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070144336.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Virology of the Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.7177.6", 
          "name": [
            "Department of Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands", 
            "Department of Virology of the Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lange", 
        "givenName": "Joep M. A.", 
        "id": "sg:person.07546645777.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07546645777.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, incorporating the Laboratory of Experimental and Clinical Immunology, University of Amsterdam, Amsterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, incorporating the Laboratory of Experimental and Clinical Immunology, University of Amsterdam, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miedema", 
        "givenName": "Frank", 
        "id": "sg:person.012755664317.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012755664317.02"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/333514a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025745633", 
          "https://doi.org/10.1038/333514a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/313686a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053223322", 
          "https://doi.org/10.1038/313686a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00916944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010786013", 
          "https://doi.org/10.1007/bf00916944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/304445a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040134095", 
          "https://doi.org/10.1038/304445a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1990-03", 
    "datePublishedReg": "1990-03-01", 
    "description": "In a cohort of 300 HIV-1-infected homosexual men, studied longitudinally, the prognostic value of T-cell proliferative responses for development of AIDS was analyzed. In 15 persons we observed that, at seroconversion, T-cell reactivity to anti-CD3 monoclonal antibody (Mab) and phytohemagglutinin (PHA) was decreased to 20 and 60% of the normal values, respectively. After seroconversion, within 3 months, the response to anti-CD3 Mab and PHA returned to 60 and 80%, respectively, of the normal magnitude and declined thereafter. To investigate whether low T-cell reactivity correlated with progression to AIDS, groups of progressors and nonprogressors were compared. In individuals who progressed to AIDS, already 12 months before diagnosis, responses to anti-CD3 Mab were virtually absent, whereas at that time CD4+ cell numbers and reactivity to horse anti-human lymphocyte serum and PHA were still comparable to values observed for nonprogressors and the asymptomatic population as a whole. In a disease-free survival analysis, low anti-CD3 Mab reactivity predicted progression to AIDS. Our findings demonstrate that low T-cell responsiveness to anti-CD3 Mab is an early marker of progression toward AIDS in HIV-1 infected individuals.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf00918194", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1092207", 
        "issn": [
          "0271-9142", 
          "1573-2592"
        ], 
        "name": "Journal of Clinical Immunology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "keywords": [
      "low T cell responsiveness", 
      "T cell reactivity", 
      "T cell responsiveness", 
      "CD3 mAb", 
      "HIV-1-infected homosexual men", 
      "low T cell reactivity", 
      "anti-human lymphocyte serum", 
      "T cell proliferative responses", 
      "anti-CD3 monoclonal antibody", 
      "human immunodeficiency virus-1", 
      "group of progressors", 
      "disease-free survival analysis", 
      "development of AIDS", 
      "immunodeficiency virus-1", 
      "CD3/TCR", 
      "immunodeficiency syndrome", 
      "prognostic value", 
      "asymptomatic population", 
      "prognostic marker", 
      "HIV-1", 
      "proliferative response", 
      "homosexual men", 
      "early marker", 
      "survival analysis", 
      "normal values", 
      "MAb reactivity", 
      "phytohemagglutinin", 
      "AIDS", 
      "monoclonal antibodies", 
      "virus 1", 
      "progression", 
      "nonprogressors", 
      "seroconversion", 
      "mAbs", 
      "cell number", 
      "months", 
      "normal magnitude", 
      "men", 
      "responsiveness", 
      "markers", 
      "response", 
      "progressors", 
      "CD4", 
      "HIV", 
      "syndrome", 
      "cohort", 
      "diagnosis", 
      "individuals", 
      "serum", 
      "antibodies", 
      "TCR", 
      "activation", 
      "reactivity", 
      "group", 
      "population", 
      "findings", 
      "persons", 
      "values", 
      "development", 
      "number", 
      "analysis", 
      "magnitude", 
      "whole"
    ], 
    "name": "Low T-cell responsiveness to activation via CD3/TCR is a prognostic marker for acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus-1 (HIV-1)-infected men", 
    "pagination": "121-127", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016517713"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00918194"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2140115"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00918194", 
      "https://app.dimensions.ai/details/publication/pub.1016517713"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_235.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf00918194"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00918194'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00918194'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00918194'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00918194'


 

This table displays all metadata directly associated to this object as RDF triples.

234 TRIPLES      21 PREDICATES      108 URIs      96 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00918194 schema:about N02af749a55da47cca53741a4b6aa7981
2 N2c455fabc3e74d068b6fd387831174e8
3 N36c2ee395fe044d7b9722e3996956446
4 N4beafa1a44b64d90b36a1b95301847e2
5 N620b5683a2974363a9bda299c9623171
6 N69498fa1dd704e80998c41a40c571e93
7 N7792fbe46b954118b5e53b95d1d570b6
8 N841f9ef6f2fa4e8fa77a6a8ce7507d98
9 N904bf5217fd44c618776278674db0046
10 Nb267383a93324fbc925061e902befa54
11 Nb3f98cd77d1648f890b7dcb1e7b3e2ca
12 Nb603eeff972143e18a121b34a72fc4a6
13 Nc4a31460f8ab47c0bcad55bf28fc58d5
14 Nc5cd5aa9400c4facb15fb60f75e2ee0d
15 Nf2f1034ba3de4f8c8b45811def8edb61
16 anzsrc-for:11
17 anzsrc-for:1103
18 schema:author N5ff14af350c949d184af4c9074e06f7d
19 schema:citation sg:pub.10.1007/bf00916944
20 sg:pub.10.1038/304445a0
21 sg:pub.10.1038/313686a0
22 sg:pub.10.1038/333514a0
23 schema:datePublished 1990-03
24 schema:datePublishedReg 1990-03-01
25 schema:description In a cohort of 300 HIV-1-infected homosexual men, studied longitudinally, the prognostic value of T-cell proliferative responses for development of AIDS was analyzed. In 15 persons we observed that, at seroconversion, T-cell reactivity to anti-CD3 monoclonal antibody (Mab) and phytohemagglutinin (PHA) was decreased to 20 and 60% of the normal values, respectively. After seroconversion, within 3 months, the response to anti-CD3 Mab and PHA returned to 60 and 80%, respectively, of the normal magnitude and declined thereafter. To investigate whether low T-cell reactivity correlated with progression to AIDS, groups of progressors and nonprogressors were compared. In individuals who progressed to AIDS, already 12 months before diagnosis, responses to anti-CD3 Mab were virtually absent, whereas at that time CD4+ cell numbers and reactivity to horse anti-human lymphocyte serum and PHA were still comparable to values observed for nonprogressors and the asymptomatic population as a whole. In a disease-free survival analysis, low anti-CD3 Mab reactivity predicted progression to AIDS. Our findings demonstrate that low T-cell responsiveness to anti-CD3 Mab is an early marker of progression toward AIDS in HIV-1 infected individuals.
26 schema:genre article
27 schema:isAccessibleForFree false
28 schema:isPartOf N5943157de0504441a4a4366e4fb40d2f
29 Nce079ec18d2d4cceacbe2cfc6291d3ef
30 sg:journal.1092207
31 schema:keywords AIDS
32 CD3 mAb
33 CD3/TCR
34 CD4
35 HIV
36 HIV-1
37 HIV-1-infected homosexual men
38 MAb reactivity
39 T cell proliferative responses
40 T cell reactivity
41 T cell responsiveness
42 TCR
43 activation
44 analysis
45 anti-CD3 monoclonal antibody
46 anti-human lymphocyte serum
47 antibodies
48 asymptomatic population
49 cell number
50 cohort
51 development
52 development of AIDS
53 diagnosis
54 disease-free survival analysis
55 early marker
56 findings
57 group
58 group of progressors
59 homosexual men
60 human immunodeficiency virus-1
61 immunodeficiency syndrome
62 immunodeficiency virus-1
63 individuals
64 low T cell reactivity
65 low T cell responsiveness
66 mAbs
67 magnitude
68 markers
69 men
70 monoclonal antibodies
71 months
72 nonprogressors
73 normal magnitude
74 normal values
75 number
76 persons
77 phytohemagglutinin
78 population
79 prognostic marker
80 prognostic value
81 progression
82 progressors
83 proliferative response
84 reactivity
85 response
86 responsiveness
87 seroconversion
88 serum
89 survival analysis
90 syndrome
91 values
92 virus 1
93 whole
94 schema:name Low T-cell responsiveness to activation via CD3/TCR is a prognostic marker for acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus-1 (HIV-1)-infected men
95 schema:pagination 121-127
96 schema:productId N35f451fac23f4e6eaf49bb626ac6b6b4
97 N8770417aa1d5469ca157f4856f57dd38
98 Nb696b491ed9a48418fb9a339a49fff8e
99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016517713
100 https://doi.org/10.1007/bf00918194
101 schema:sdDatePublished 2022-09-02T15:48
102 schema:sdLicense https://scigraph.springernature.com/explorer/license/
103 schema:sdPublisher N4d06baf14422481dba22140195832653
104 schema:url https://doi.org/10.1007/bf00918194
105 sgo:license sg:explorer/license/
106 sgo:sdDataset articles
107 rdf:type schema:ScholarlyArticle
108 N02af749a55da47cca53741a4b6aa7981 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Prognosis
110 rdf:type schema:DefinedTerm
111 N2c455fabc3e74d068b6fd387831174e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Lymphocyte Activation
113 rdf:type schema:DefinedTerm
114 N2dc7a9cfef7e41e382b6b8559f60157b rdf:first sg:person.01070144336.28
115 rdf:rest N9690197163ba4cfc9ad8628ad4ce6b96
116 N35f451fac23f4e6eaf49bb626ac6b6b4 schema:name dimensions_id
117 schema:value pub.1016517713
118 rdf:type schema:PropertyValue
119 N36c2ee395fe044d7b9722e3996956446 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Antigens, Differentiation, T-Lymphocyte
121 rdf:type schema:DefinedTerm
122 N4beafa1a44b64d90b36a1b95301847e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Acquired Immunodeficiency Syndrome
124 rdf:type schema:DefinedTerm
125 N4d06baf14422481dba22140195832653 schema:name Springer Nature - SN SciGraph project
126 rdf:type schema:Organization
127 N5943157de0504441a4a4366e4fb40d2f schema:issueNumber 2
128 rdf:type schema:PublicationIssue
129 N5ff14af350c949d184af4c9074e06f7d rdf:first sg:person.0760130432.03
130 rdf:rest N8acd7f897a8f4a638ea6122895d9343c
131 N620b5683a2974363a9bda299c9623171 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Statistics as Topic
133 rdf:type schema:DefinedTerm
134 N69498fa1dd704e80998c41a40c571e93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Humans
136 rdf:type schema:DefinedTerm
137 N7792fbe46b954118b5e53b95d1d570b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Predictive Value of Tests
139 rdf:type schema:DefinedTerm
140 N841f9ef6f2fa4e8fa77a6a8ce7507d98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name T-Lymphocytes
142 rdf:type schema:DefinedTerm
143 N8770417aa1d5469ca157f4856f57dd38 schema:name pubmed_id
144 schema:value 2140115
145 rdf:type schema:PropertyValue
146 N8acd7f897a8f4a638ea6122895d9343c rdf:first sg:person.012150170602.32
147 rdf:rest N2dc7a9cfef7e41e382b6b8559f60157b
148 N904bf5217fd44c618776278674db0046 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Male
150 rdf:type schema:DefinedTerm
151 N9690197163ba4cfc9ad8628ad4ce6b96 rdf:first sg:person.07546645777.21
152 rdf:rest Nd57f77e452a6476897612047b2f5aa81
153 Nb267383a93324fbc925061e902befa54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name CD3 Complex
155 rdf:type schema:DefinedTerm
156 Nb3f98cd77d1648f890b7dcb1e7b3e2ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name HIV-1
158 rdf:type schema:DefinedTerm
159 Nb603eeff972143e18a121b34a72fc4a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name HIV Infections
161 rdf:type schema:DefinedTerm
162 Nb696b491ed9a48418fb9a339a49fff8e schema:name doi
163 schema:value 10.1007/bf00918194
164 rdf:type schema:PropertyValue
165 Nc4a31460f8ab47c0bcad55bf28fc58d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Receptors, Antigen, T-Cell
167 rdf:type schema:DefinedTerm
168 Nc5cd5aa9400c4facb15fb60f75e2ee0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Cohort Studies
170 rdf:type schema:DefinedTerm
171 Nce079ec18d2d4cceacbe2cfc6291d3ef schema:volumeNumber 10
172 rdf:type schema:PublicationVolume
173 Nd57f77e452a6476897612047b2f5aa81 rdf:first sg:person.012755664317.02
174 rdf:rest rdf:nil
175 Nf2f1034ba3de4f8c8b45811def8edb61 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Antibodies, Monoclonal
177 rdf:type schema:DefinedTerm
178 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
179 schema:name Medical and Health Sciences
180 rdf:type schema:DefinedTerm
181 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
182 schema:name Clinical Sciences
183 rdf:type schema:DefinedTerm
184 sg:journal.1092207 schema:issn 0271-9142
185 1573-2592
186 schema:name Journal of Clinical Immunology
187 schema:publisher Springer Nature
188 rdf:type schema:Periodical
189 sg:person.01070144336.28 schema:affiliation grid-institutes:grid.7177.6
190 schema:familyName de Wolf
191 schema:givenName Frank
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070144336.28
193 rdf:type schema:Person
194 sg:person.012150170602.32 schema:affiliation grid-institutes:None
195 schema:familyName Roos
196 schema:givenName Marijke Th. L.
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012150170602.32
198 rdf:type schema:Person
199 sg:person.012755664317.02 schema:affiliation grid-institutes:None
200 schema:familyName Miedema
201 schema:givenName Frank
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012755664317.02
203 rdf:type schema:Person
204 sg:person.07546645777.21 schema:affiliation grid-institutes:grid.7177.6
205 schema:familyName Lange
206 schema:givenName Joep M. A.
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07546645777.21
208 rdf:type schema:Person
209 sg:person.0760130432.03 schema:affiliation grid-institutes:grid.7177.6
210 schema:familyName Schellekens
211 schema:givenName Peter Th. A.
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760130432.03
213 rdf:type schema:Person
214 sg:pub.10.1007/bf00916944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010786013
215 https://doi.org/10.1007/bf00916944
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/304445a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040134095
218 https://doi.org/10.1038/304445a0
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/313686a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053223322
221 https://doi.org/10.1038/313686a0
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/333514a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025745633
224 https://doi.org/10.1038/333514a0
225 rdf:type schema:CreativeWork
226 grid-institutes:None schema:alternateName Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, incorporating the Laboratory of Experimental and Clinical Immunology, University of Amsterdam, Amsterdam, The Netherlands
227 schema:name Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, incorporating the Laboratory of Experimental and Clinical Immunology, University of Amsterdam, Amsterdam, The Netherlands
228 rdf:type schema:Organization
229 grid-institutes:grid.7177.6 schema:alternateName Department of Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
230 Department of Virology of the Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
231 schema:name Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, incorporating the Laboratory of Experimental and Clinical Immunology, University of Amsterdam, Amsterdam, The Netherlands
232 Department of Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
233 Department of Virology of the Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
234 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...