Peptide opioids and morphine effects on inflammatory process View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-12

AUTHORS

A. Mazzone, G. Ricevuti, D. Pasotti, A. Fioravanti, M. Marcoli, S. Lecchini, A. Notario, G. M. Frigo

ABSTRACT

Morphine was found to inhibit human granulocyte aggregation and ATP, thromboxane B2 (TxB2), and leukotriene B4 (LTB4) secretion during cell aggregation. None of the opioid peptides tested [(D-Ala2, D-Leu5)-enkephalin (DADL), (D-Ala2, N-Me-Phe4, Gly-ol5)-enkephalin (DAGO) or dynorphin 1-9 (Dyn 1-9)] was capable of mimicking morphine effects, while Dyn 1-9 per se induced TxB2 and LTB4 secretion from granulocytes. Morphine inhibition of both cell aggregation and ATP, but not of arachidonic acid metabolism product secretion, was prevented by naloxone. The naloxone-sensitive impairment by morphine of CD11b-CD18 complex surface expression observed could play a role in opioid inhibition of granulocyte activation. More... »

PAGES

717-726

References to SciGraph publications

  • 1986. Opioid Peptide Effects on Leukocyte Migration in ENKEPHALINS AND ENDORPHINS
  • 1986. Enkephalins: Mediators of Stress-Induced Immunomodulation in ENKEPHALINS AND ENDORPHINS
  • 1989-08. The neutrophil revisited in INFLAMMATION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00916374

    DOI

    http://dx.doi.org/10.1007/bf00916374

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1982531


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    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00916374'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00916374'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00916374'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00916374'


     

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