Changes in T-lymphocyte subsets during childhood Epstein-Barr virus infectious mononucleosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-04

AUTHORS

Kristen A. Weigle, Ciro Valent Sumaya, Milka M. Montiel

ABSTRACT

Lymphocyte subsets were measured using monoclonal antibodies in 11 children with Epstein-Barr virus-induced infectious mononucleosis and compared with those of 10 normal children. In acute infectious mononucleosis the percentage of T8+ lymphocytes was greater while the percentage of T4+ lymphocytes and the T4+ to T8+ ratio were less than those measured in normal children. The percentage and absolute number of T lymphocytes, as enumerated by E rosetting, did not differ from the values for normal children. The children with acute infectious mononucleosis had a somewhat lower T8+ response than that observed in four adult infectious mononucleosis patients. With clinical recovery, the T lymphocyte-subset values returned toward normal. T8+ lymphocytes, a phenotype subset with predominantly suppressor activity, presumably reduce normal cellular immune functions transiently and may limit the continued proliferation of Epstein-Barr virus-infected B lymphocytes. More... »

PAGES

151-155

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00915486

DOI

http://dx.doi.org/10.1007/bf00915486

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030622734

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6304139


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