Pre-B cells: Normal and abnormal development View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1981-04

AUTHORS

Max D. Cooper

ABSTRACT

The immediate precursors of B lymphocytes have been recently identified in fetal liver and in bone marrow. Immunoglobulin genes, first of the heavy-chain gene family and later from one of the light-chain gene families, are selected and undergo functional rearrangements on one of each chromosomal pair during this stage of differentiation. Thus clonal diversity is generated among cycling pre-B cells that lack the surface antibody expression which characterizes their B-cell progeny. While the number of discriminating markers for pre-B cells is still limited, examination of bone marrow pre-B cells containing cytoplasmic μ chains but lacking surface immunoglobulin has already revealed an informative spectrum of early differentiation defects in antibody deficiency diseases and malignancies of B lineage. More... »

PAGES

81-89

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00915383

DOI

http://dx.doi.org/10.1007/bf00915383

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032935481

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6801081


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