The effects of an ACTH (4–9) analogue on development of cisplatin neuropathy in testicular cancer: A randomized trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1994-07

AUTHORS

J. M. A. van Gerven, A. Hovestadt, J. W. B. Moll, C. J. Rodenburg, T. A. W. Splinter, A. T. van Oosterom, L. Keizer, T. E. Drogendijk, C. M. Groenhout, Ch. J. Vecht, J. P. Neijt

ABSTRACT

The efficacy of the ACTH (4-9) analogue Org 2766 in the prevention of subclinical cisplatin neuropathy was assessed in a double-blind placebo-controlled multi-centre study in patients with testicular cancer or adenocarcinoma of unknown primary. Forty-two patients received at least four cycles of cisplatin (100 mg/m2 per cycle), together with subcutaneous injections of Org 2766 (2 mg/day for 5 consecutive days) or placebo. Vibratory threshold was used as a measure of neuropathy. For each individual patient, the influence of cisplatin on vibratory perception was quantified by the slope of the regression line between the natural logarithm of the vibratory thresholds and the number of cycles. From the slopes, the proportional increase of vibratory threshold per cycle of cisplatin was calculated. On average, vibratory thresholds increased by 42% with each cycle of 100 mg/m2 of cisplatin in the placebo group, and by 19% during treatment with Org 2766. The influence of cisplatin on vibratory thresholds was highly significant in the placebo group (P < 0.0001), and of borderline significance in the group treated with Org 2766 (P = 0.06). The difference in slopes between the two groups was of borderline statistical significance (Wilcoxon's two-sample test: P = 0.06; analysis of variance: P = 0.04). These results show that Org 2766 cannot completely prevent cisplatin neuropathy in young men with testicular cancer, but nerve damage may be ameliorated by the use of this ACTH (4-9) analogue. More... »

PAGES

432-435

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00900961

DOI

http://dx.doi.org/10.1007/bf00900961

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006103862

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7931444


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adrenocorticotropic Hormone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anticonvulsants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cisplatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Double-Blind Method", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Injections, Subcutaneous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Unknown Primary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptide Fragments", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peripheral Nervous System Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sensory Thresholds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Testicular Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Departments of Neurology, Dr. Daniel den Hoed Cancer Center and University Hospital Rotterdam, P.O. Box 5201, 3008, AE Rotterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Gerven", 
        "givenName": "J. M. A.", 
        "id": "sg:person.01356741442.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356741442.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Departments of Neurology, Dr. Daniel den Hoed Cancer Center and University Hospital Rotterdam, P.O. Box 5201, 3008, AE Rotterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hovestadt", 
        "givenName": "A.", 
        "id": "sg:person.0747167517.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747167517.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Departments of Neurology, Dr. Daniel den Hoed Cancer Center and University Hospital Rotterdam, P.O. Box 5201, 3008, AE Rotterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moll", 
        "givenName": "J. W. B.", 
        "id": "sg:person.01135455430.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135455430.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medical Oncology, Dr. Daniel den Hoed Cancer Center and University Hospital Rotterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rodenburg", 
        "givenName": "C. J.", 
        "id": "sg:person.015353403074.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015353403074.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medical Oncology, Dr. Daniel den Hoed Cancer Center and University Hospital Rotterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Splinter", 
        "givenName": "T. A. W.", 
        "id": "sg:person.014314042704.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014314042704.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medical Oncology, University Hospital Antwerpen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Oosterom", 
        "givenName": "A. T.", 
        "id": "sg:person.0653245357.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653245357.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leiden University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.10419.3d", 
          "name": [
            "University Hospital Leiden, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Keizer", 
        "givenName": "L.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Biostatistics, Dr. Daniel den Hoed Cancer Center and University Hospital Rotterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Drogendijk", 
        "givenName": "T. E.", 
        "id": "sg:person.01200240742.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200240742.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Oragon International b.v., Oss"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Groenhout", 
        "givenName": "C. M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Departments of Neurology, Dr. Daniel den Hoed Cancer Center and University Hospital Rotterdam, P.O. Box 5201, 3008, AE Rotterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vecht", 
        "givenName": "Ch. J.", 
        "id": "sg:person.011666232764.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011666232764.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Utrecht", 
          "id": "https://www.grid.ac/institutes/grid.7692.a", 
          "name": [
            "Department of Medical Oncology, University Hospital Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Neijt", 
        "givenName": "J. P.", 
        "id": "sg:person.013371624404.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013371624404.19"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00686953", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008493247", 
          "https://doi.org/10.1007/bf00686953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00686953", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008493247", 
          "https://doi.org/10.1007/bf00686953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(197912)44:6<2026::aid-cncr2820440610>3.0.co;2-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014195436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19901015)66:8<1697::aid-cncr2820660808>3.0.co;2-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015947410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19841001)54:7<1269::aid-cncr2820540707>3.0.co;2-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026577595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0277-5379(91)90549-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027932565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.42.9.793", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030734121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00833914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033676507", 
          "https://doi.org/10.1007/bf00833914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199001113220204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051384977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.34.7.934", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064365496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.annonc.a057688", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077314601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1986.4.8.1199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078817273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000411639", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079500752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080006769", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1994-07", 
    "datePublishedReg": "1994-07-01", 
    "description": "The efficacy of the ACTH (4-9) analogue Org 2766 in the prevention of subclinical cisplatin neuropathy was assessed in a double-blind placebo-controlled multi-centre study in patients with testicular cancer or adenocarcinoma of unknown primary. Forty-two patients received at least four cycles of cisplatin (100 mg/m2 per cycle), together with subcutaneous injections of Org 2766 (2 mg/day for 5 consecutive days) or placebo. Vibratory threshold was used as a measure of neuropathy. For each individual patient, the influence of cisplatin on vibratory perception was quantified by the slope of the regression line between the natural logarithm of the vibratory thresholds and the number of cycles. From the slopes, the proportional increase of vibratory threshold per cycle of cisplatin was calculated. On average, vibratory thresholds increased by 42% with each cycle of 100 mg/m2 of cisplatin in the placebo group, and by 19% during treatment with Org 2766. The influence of cisplatin on vibratory thresholds was highly significant in the placebo group (P < 0.0001), and of borderline significance in the group treated with Org 2766 (P = 0.06). The difference in slopes between the two groups was of borderline statistical significance (Wilcoxon's two-sample test: P = 0.06; analysis of variance: P = 0.04). These results show that Org 2766 cannot completely prevent cisplatin neuropathy in young men with testicular cancer, but nerve damage may be ameliorated by the use of this ACTH (4-9) analogue.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00900961", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1014525", 
        "issn": [
          "0340-5354", 
          "1432-1459"
        ], 
        "name": "Journal of Neurology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "241"
      }
    ], 
    "name": "The effects of an ACTH (4\u20139) analogue on development of cisplatin neuropathy in testicular cancer: A randomized trial", 
    "pagination": "432-435", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1d13aea7c358030da64cf7fb0b55414edfe4e28286ad5650d81ebfa6ab8a3969"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7931444"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0423161"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00900961"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1006103862"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00900961", 
      "https://app.dimensions.ai/details/publication/pub.1006103862"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000494.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF00900961"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00900961'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00900961'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00900961'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00900961'


 

This table displays all metadata directly associated to this object as RDF triples.

262 TRIPLES      21 PREDICATES      58 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00900961 schema:about N03671c278ab84ad5a83b0cf54dabd9ec
2 N1dde0588b4b249c18dd09c3fe733137a
3 N22713529e3bc41b8935a02f171d54de1
4 N3a4f8c9170ad4e7083d7b6d601b95a59
5 N3fd367cc7e634a3b810afe8bb410555d
6 N45aa27010f5c48b7b0eeaf6ef26e5ee6
7 N53116c7b45524b27b04d4eec61869e8f
8 N5df7f7b1853247649c2d55a496c18e6f
9 N6cb23fad42494df68c33547816133876
10 N7b7e1a57feed4c5286b3a097f25d0e95
11 N8a27e5767dec45e484c65b73d6d72c94
12 Na2aa29da0cb447698b77561c981d0941
13 Nae060f9eede4454693b74d3c77646ee3
14 Nbdec303e7a714233bafda7a3875a8e95
15 Ncf070f4d942a4de99d6038db318f1e4b
16 Ne67e98f26ad248efaeff239066763718
17 anzsrc-for:11
18 anzsrc-for:1109
19 schema:author N930bed81ce9b44ab830a54cba1103a76
20 schema:citation sg:pub.10.1007/bf00686953
21 sg:pub.10.1007/bf00833914
22 https://app.dimensions.ai/details/publication/pub.1080006769
23 https://doi.org/10.1002/1097-0142(197912)44:6<2026::aid-cncr2820440610>3.0.co;2-1
24 https://doi.org/10.1002/1097-0142(19841001)54:7<1269::aid-cncr2820540707>3.0.co;2-9
25 https://doi.org/10.1002/1097-0142(19901015)66:8<1697::aid-cncr2820660808>3.0.co;2-g
26 https://doi.org/10.1016/0277-5379(91)90549-s
27 https://doi.org/10.1056/nejm199001113220204
28 https://doi.org/10.1093/oxfordjournals.annonc.a057688
29 https://doi.org/10.1136/jnnp.42.9.793
30 https://doi.org/10.1159/000411639
31 https://doi.org/10.1200/jco.1986.4.8.1199
32 https://doi.org/10.1212/wnl.34.7.934
33 schema:datePublished 1994-07
34 schema:datePublishedReg 1994-07-01
35 schema:description The efficacy of the ACTH (4-9) analogue Org 2766 in the prevention of subclinical cisplatin neuropathy was assessed in a double-blind placebo-controlled multi-centre study in patients with testicular cancer or adenocarcinoma of unknown primary. Forty-two patients received at least four cycles of cisplatin (100 mg/m2 per cycle), together with subcutaneous injections of Org 2766 (2 mg/day for 5 consecutive days) or placebo. Vibratory threshold was used as a measure of neuropathy. For each individual patient, the influence of cisplatin on vibratory perception was quantified by the slope of the regression line between the natural logarithm of the vibratory thresholds and the number of cycles. From the slopes, the proportional increase of vibratory threshold per cycle of cisplatin was calculated. On average, vibratory thresholds increased by 42% with each cycle of 100 mg/m2 of cisplatin in the placebo group, and by 19% during treatment with Org 2766. The influence of cisplatin on vibratory thresholds was highly significant in the placebo group (P < 0.0001), and of borderline significance in the group treated with Org 2766 (P = 0.06). The difference in slopes between the two groups was of borderline statistical significance (Wilcoxon's two-sample test: P = 0.06; analysis of variance: P = 0.04). These results show that Org 2766 cannot completely prevent cisplatin neuropathy in young men with testicular cancer, but nerve damage may be ameliorated by the use of this ACTH (4-9) analogue.
36 schema:genre research_article
37 schema:inLanguage en
38 schema:isAccessibleForFree true
39 schema:isPartOf N5d2f25cd176c46a89aaa84195f32d209
40 Ncc279ce7cab64fef904dbd6050817a1f
41 sg:journal.1014525
42 schema:name The effects of an ACTH (4–9) analogue on development of cisplatin neuropathy in testicular cancer: A randomized trial
43 schema:pagination 432-435
44 schema:productId N23111c1091df40d597724aa844d49039
45 N9e58ee01b5ca452eb10239e13d8f20dc
46 Na3b0c92979c04b24aa518cfe30b266fa
47 Nc6400052eb824dd5b649729c9beb5e56
48 Ned0ef6286b5344d89316e606d2da2060
49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006103862
50 https://doi.org/10.1007/bf00900961
51 schema:sdDatePublished 2019-04-10T18:16
52 schema:sdLicense https://scigraph.springernature.com/explorer/license/
53 schema:sdPublisher Nfe184446e8494e099c15afffaf3960d1
54 schema:url http://link.springer.com/10.1007/BF00900961
55 sgo:license sg:explorer/license/
56 sgo:sdDataset articles
57 rdf:type schema:ScholarlyArticle
58 N0012433c1fa24dccb69538e157e5c76c schema:name Departments of Neurology, Dr. Daniel den Hoed Cancer Center and University Hospital Rotterdam, P.O. Box 5201, 3008, AE Rotterdam, The Netherlands
59 rdf:type schema:Organization
60 N02a4d9fb1dd9463f9fedd9faa4a59aa2 rdf:first sg:person.011666232764.98
61 rdf:rest Naf8e3d9aadb242df98982260b800f08d
62 N03671c278ab84ad5a83b0cf54dabd9ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Double-Blind Method
64 rdf:type schema:DefinedTerm
65 N0c8d8ec7931d45569899b0e5df6f2af7 rdf:first N8542f4e98cd04a008d0e5d142df39a4e
66 rdf:rest N850c7318239d46229bb6a5a3c51ec5ed
67 N0d9b0096e80d47e9b19b544f77c6f7e2 rdf:first sg:person.015353403074.67
68 rdf:rest N3650eb71b1a24828ae7a7ba0939e9794
69 N0f87a04f9157470da8ec74ae12df67c4 schema:name Departments of Neurology, Dr. Daniel den Hoed Cancer Center and University Hospital Rotterdam, P.O. Box 5201, 3008, AE Rotterdam, The Netherlands
70 rdf:type schema:Organization
71 N18df00e19be04380a471f710a1261f7a schema:name Department of Medical Oncology, Dr. Daniel den Hoed Cancer Center and University Hospital Rotterdam, The Netherlands
72 rdf:type schema:Organization
73 N1dde0588b4b249c18dd09c3fe733137a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Adrenocorticotropic Hormone
75 rdf:type schema:DefinedTerm
76 N22713529e3bc41b8935a02f171d54de1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Male
78 rdf:type schema:DefinedTerm
79 N23111c1091df40d597724aa844d49039 schema:name readcube_id
80 schema:value 1d13aea7c358030da64cf7fb0b55414edfe4e28286ad5650d81ebfa6ab8a3969
81 rdf:type schema:PropertyValue
82 N2847203001534f568a87f0258287587a schema:name Departments of Neurology, Dr. Daniel den Hoed Cancer Center and University Hospital Rotterdam, P.O. Box 5201, 3008, AE Rotterdam, The Netherlands
83 rdf:type schema:Organization
84 N3650eb71b1a24828ae7a7ba0939e9794 rdf:first sg:person.014314042704.42
85 rdf:rest N72915b82d4de4dc4b0913814f57d6e2f
86 N3a4f8c9170ad4e7083d7b6d601b95a59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Injections, Subcutaneous
88 rdf:type schema:DefinedTerm
89 N3fd367cc7e634a3b810afe8bb410555d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Testicular Neoplasms
91 rdf:type schema:DefinedTerm
92 N45aa27010f5c48b7b0eeaf6ef26e5ee6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Neoplasms, Unknown Primary
94 rdf:type schema:DefinedTerm
95 N53116c7b45524b27b04d4eec61869e8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Middle Aged
97 rdf:type schema:DefinedTerm
98 N54c978942a5f4c4fbed1985c04911b48 rdf:first sg:person.01135455430.76
99 rdf:rest N0d9b0096e80d47e9b19b544f77c6f7e2
100 N5d2f25cd176c46a89aaa84195f32d209 schema:issueNumber 7
101 rdf:type schema:PublicationIssue
102 N5df7f7b1853247649c2d55a496c18e6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Adult
104 rdf:type schema:DefinedTerm
105 N62dfca3756034929a769fc818004cac5 schema:name Departments of Neurology, Dr. Daniel den Hoed Cancer Center and University Hospital Rotterdam, P.O. Box 5201, 3008, AE Rotterdam, The Netherlands
106 rdf:type schema:Organization
107 N6cb23fad42494df68c33547816133876 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Adenocarcinoma
109 rdf:type schema:DefinedTerm
110 N72915b82d4de4dc4b0913814f57d6e2f rdf:first sg:person.0653245357.14
111 rdf:rest N0c8d8ec7931d45569899b0e5df6f2af7
112 N7b7e1a57feed4c5286b3a097f25d0e95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Peptide Fragments
114 rdf:type schema:DefinedTerm
115 N7ba86a5f47a4485cabefabf7294d0299 schema:name Department of Medical Oncology, Dr. Daniel den Hoed Cancer Center and University Hospital Rotterdam, The Netherlands
116 rdf:type schema:Organization
117 N84603c10ec104580a90fccf86dc13b74 schema:name Oragon International b.v., Oss
118 rdf:type schema:Organization
119 N850c7318239d46229bb6a5a3c51ec5ed rdf:first sg:person.01200240742.47
120 rdf:rest Ne6d60dee034d456bbea49b30517c0fd3
121 N8542f4e98cd04a008d0e5d142df39a4e schema:affiliation https://www.grid.ac/institutes/grid.10419.3d
122 schema:familyName Keizer
123 schema:givenName L.
124 rdf:type schema:Person
125 N8a27e5767dec45e484c65b73d6d72c94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Humans
127 rdf:type schema:DefinedTerm
128 N90e5c090021d4e248fa98d408d30363f rdf:first sg:person.0747167517.31
129 rdf:rest N54c978942a5f4c4fbed1985c04911b48
130 N930bed81ce9b44ab830a54cba1103a76 rdf:first sg:person.01356741442.99
131 rdf:rest N90e5c090021d4e248fa98d408d30363f
132 N9e58ee01b5ca452eb10239e13d8f20dc schema:name nlm_unique_id
133 schema:value 0423161
134 rdf:type schema:PropertyValue
135 Na2aa29da0cb447698b77561c981d0941 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Sensory Thresholds
137 rdf:type schema:DefinedTerm
138 Na3b0c92979c04b24aa518cfe30b266fa schema:name doi
139 schema:value 10.1007/bf00900961
140 rdf:type schema:PropertyValue
141 Nae060f9eede4454693b74d3c77646ee3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Cisplatin
143 rdf:type schema:DefinedTerm
144 Naf2224d0066145a58f4646ca0085a9b2 schema:name Department of Biostatistics, Dr. Daniel den Hoed Cancer Center and University Hospital Rotterdam, The Netherlands
145 rdf:type schema:Organization
146 Naf8e3d9aadb242df98982260b800f08d rdf:first sg:person.013371624404.19
147 rdf:rest rdf:nil
148 Nbdec303e7a714233bafda7a3875a8e95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Peripheral Nervous System Diseases
150 rdf:type schema:DefinedTerm
151 Nc630c215847146d0aa54c1975c567764 schema:affiliation N84603c10ec104580a90fccf86dc13b74
152 schema:familyName Groenhout
153 schema:givenName C. M.
154 rdf:type schema:Person
155 Nc6400052eb824dd5b649729c9beb5e56 schema:name pubmed_id
156 schema:value 7931444
157 rdf:type schema:PropertyValue
158 Ncc279ce7cab64fef904dbd6050817a1f schema:volumeNumber 241
159 rdf:type schema:PublicationVolume
160 Ncf070f4d942a4de99d6038db318f1e4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Adolescent
162 rdf:type schema:DefinedTerm
163 Ne67e98f26ad248efaeff239066763718 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Anticonvulsants
165 rdf:type schema:DefinedTerm
166 Ne6d60dee034d456bbea49b30517c0fd3 rdf:first Nc630c215847146d0aa54c1975c567764
167 rdf:rest N02a4d9fb1dd9463f9fedd9faa4a59aa2
168 Ne91d1c829d2848c8b00aefb51c3ebee0 schema:name Department of Medical Oncology, University Hospital Antwerpen, The Netherlands
169 rdf:type schema:Organization
170 Ned0ef6286b5344d89316e606d2da2060 schema:name dimensions_id
171 schema:value pub.1006103862
172 rdf:type schema:PropertyValue
173 Nfe184446e8494e099c15afffaf3960d1 schema:name Springer Nature - SN SciGraph project
174 rdf:type schema:Organization
175 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
176 schema:name Medical and Health Sciences
177 rdf:type schema:DefinedTerm
178 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
179 schema:name Neurosciences
180 rdf:type schema:DefinedTerm
181 sg:journal.1014525 schema:issn 0340-5354
182 1432-1459
183 schema:name Journal of Neurology
184 rdf:type schema:Periodical
185 sg:person.01135455430.76 schema:affiliation N0012433c1fa24dccb69538e157e5c76c
186 schema:familyName Moll
187 schema:givenName J. W. B.
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135455430.76
189 rdf:type schema:Person
190 sg:person.011666232764.98 schema:affiliation N0f87a04f9157470da8ec74ae12df67c4
191 schema:familyName Vecht
192 schema:givenName Ch. J.
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011666232764.98
194 rdf:type schema:Person
195 sg:person.01200240742.47 schema:affiliation Naf2224d0066145a58f4646ca0085a9b2
196 schema:familyName Drogendijk
197 schema:givenName T. E.
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200240742.47
199 rdf:type schema:Person
200 sg:person.013371624404.19 schema:affiliation https://www.grid.ac/institutes/grid.7692.a
201 schema:familyName Neijt
202 schema:givenName J. P.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013371624404.19
204 rdf:type schema:Person
205 sg:person.01356741442.99 schema:affiliation N62dfca3756034929a769fc818004cac5
206 schema:familyName van Gerven
207 schema:givenName J. M. A.
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356741442.99
209 rdf:type schema:Person
210 sg:person.014314042704.42 schema:affiliation N7ba86a5f47a4485cabefabf7294d0299
211 schema:familyName Splinter
212 schema:givenName T. A. W.
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014314042704.42
214 rdf:type schema:Person
215 sg:person.015353403074.67 schema:affiliation N18df00e19be04380a471f710a1261f7a
216 schema:familyName Rodenburg
217 schema:givenName C. J.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015353403074.67
219 rdf:type schema:Person
220 sg:person.0653245357.14 schema:affiliation Ne91d1c829d2848c8b00aefb51c3ebee0
221 schema:familyName van Oosterom
222 schema:givenName A. T.
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653245357.14
224 rdf:type schema:Person
225 sg:person.0747167517.31 schema:affiliation N2847203001534f568a87f0258287587a
226 schema:familyName Hovestadt
227 schema:givenName A.
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747167517.31
229 rdf:type schema:Person
230 sg:pub.10.1007/bf00686953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008493247
231 https://doi.org/10.1007/bf00686953
232 rdf:type schema:CreativeWork
233 sg:pub.10.1007/bf00833914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033676507
234 https://doi.org/10.1007/bf00833914
235 rdf:type schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1080006769 schema:CreativeWork
237 https://doi.org/10.1002/1097-0142(197912)44:6<2026::aid-cncr2820440610>3.0.co;2-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014195436
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1002/1097-0142(19841001)54:7<1269::aid-cncr2820540707>3.0.co;2-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026577595
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1002/1097-0142(19901015)66:8<1697::aid-cncr2820660808>3.0.co;2-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1015947410
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/0277-5379(91)90549-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1027932565
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1056/nejm199001113220204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051384977
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1093/oxfordjournals.annonc.a057688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077314601
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1136/jnnp.42.9.793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030734121
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1159/000411639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079500752
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1200/jco.1986.4.8.1199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078817273
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1212/wnl.34.7.934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064365496
256 rdf:type schema:CreativeWork
257 https://www.grid.ac/institutes/grid.10419.3d schema:alternateName Leiden University Medical Center
258 schema:name University Hospital Leiden, The Netherlands
259 rdf:type schema:Organization
260 https://www.grid.ac/institutes/grid.7692.a schema:alternateName University Medical Center Utrecht
261 schema:name Department of Medical Oncology, University Hospital Utrecht, The Netherlands
262 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...