[99mTc]TRODAT-1: A novel technetium-99m complex as a dopamine transporter imaging agent View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-04

AUTHORS

Mei-Ping Kung, D. Andrew Stevenson, Karl Plössl, Sanath K. Meegalla, Andrew Beckwith, William D. Essman, Mu Mu, Irwin Lucki, Hank F. Kung

ABSTRACT

Technetium-99m is the most commonly used radionuclide in routine nuclear medicine imaging procedures. Development of 99mTc-labeled receptor-specific imaging agents for studying the central nervous system is potentially useful for evaluation of brain function in normal and disease states. A novel 99mTc-labeled tropane derivative, [99mTc]TRODAT-1, which is useful as a potential CNS dopamine transporter imaging agent, was evaluated and characterized. After i. v. injection into rats, [99mTc]TRODAT-1 displayed specific brain uptake in the rat striatal region (striatum-cerebellum/cerebellum ratio 1.8 at 60 min), where dopamine neurons are concentrated. The specific striatal uptake could be blocked by pretreating rats with a dose of competing dopamine transporter ligand, beta-CIT (or RTI-55, i.v., 1 mg/kg). However, the specific striatal uptake of [99mTc]TRODAT-1 was not affected by co-injection of excess free ligand (TRODAT-1, up to 200 microg per rat) or by pretreating the rats with haloperidol (i.v., 1 mg/kg). The specific uptake in striatal regions of rats that had prior 6-hydroxydopamine lesion in the substantia nigra area showed a dramatic reduction. The radioactive material recovered from the rat striatal homogenates at 60 min after i.v. injection of [99mTc]TRODAT-1 showed primarily the original compound (>95%), a good indication of in vivo stability in brain tissue. Similar and comparable organ distribution patterns and brain regional uptakes of [99mTc]TRODAT-1 were obtained for male and female rats. Ex vivo autoradiography results of rat brain sections further confirmed the high uptake and retention of [99mTc]TRODAT-1 in the striatal region. In vitro binding studies measuring the affinity to dopamine transporters for the free ligand, TRODAT-1, and a nonradioactive rhenium derivative, Re-TRODAT-1, showed Ki values of 9.7 nM and 14.1 nM, respectively. Behavioral studies in rats using the free ligand, TRODAT-1 and Re-TRODAT-1 indicated that, unlike other tropane derivatives, they displayed no effect on locomotor activity, suggesting low toxicity. These results strongly support the conclusions that this novel 99mTc radioligand binds selectively to dopamine transporters in the brain and that is is potentially useful for in vivo assessment of the loss of dopamine neurons in Parkinson's and other neurodegenerative diseases. More... »

PAGES

372-380

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00881808

DOI

http://dx.doi.org/10.1007/bf00881808

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019311623

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9096087


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autoradiography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carrier Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dopamine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dopamine Plasma Membrane Transport Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Glycoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Transport Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Motor Activity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Tissue Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organotechnetium Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sex Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Distribution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tomography, Emission-Computed, Single-Photon", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tropanes", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, 19104, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kung", 
        "givenName": "Mei-Ping", 
        "id": "sg:person.01145435671.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145435671.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, 19104, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stevenson", 
        "givenName": "D. Andrew", 
        "id": "sg:person.01217161223.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217161223.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, 19104, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pl\u00f6ssl", 
        "givenName": "Karl", 
        "id": "sg:person.0764777622.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764777622.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, 19104, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meegalla", 
        "givenName": "Sanath K.", 
        "id": "sg:person.01045627611.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045627611.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, 19104, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beckwith", 
        "givenName": "Andrew", 
        "id": "sg:person.01235331147.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235331147.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Psychiatry, University of Pennsylvania, Philadelphia, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Essman", 
        "givenName": "William D.", 
        "id": "sg:person.01323731720.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323731720.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, 19104, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mu", 
        "givenName": "Mu", 
        "id": "sg:person.01022556575.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022556575.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Psychiatry, University of Pennsylvania, Philadelphia, USA", 
            "Department of Pharmacology, University of Pennsylvania, Philadelphia, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lucki", 
        "givenName": "Irwin", 
        "id": "sg:person.01062136247.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062136247.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, 19104, Philadelphia, PA, USA", 
            "Department of Pharmacology, University of Pennsylvania, Philadelphia, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kung", 
        "givenName": "Hank F.", 
        "id": "sg:person.0615735606.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615735606.55"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/ana.410340331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004318172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.90.24.11965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006690895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(80)90515-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007065635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0969-8051(94)90004-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010956551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/syn.890120203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012005644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0969-8051(94)90009-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012294328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1988.64", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017572287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1988.64", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017572287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02244916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017628568", 
          "https://doi.org/10.1007/bf02244916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02244916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017628568", 
          "https://doi.org/10.1007/bf02244916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/syn.890100210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018012474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410380407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022216822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(84)91280-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023043817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(84)91280-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023043817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01254571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023163508", 
          "https://doi.org/10.1007/bf01254571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01254571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023163508", 
          "https://doi.org/10.1007/bf01254571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01254479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026914665", 
          "https://doi.org/10.1007/bf01254479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01254479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026914665", 
          "https://doi.org/10.1007/bf01254479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01253106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031825778", 
          "https://doi.org/10.1007/bf01253106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01253106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031825778", 
          "https://doi.org/10.1007/bf01253106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000117169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037826085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(95)00611-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041728880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/syn.890040412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041932871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000117341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041981898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2396(199611)24:3<273::aid-syn10>3.0.co;2-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042470140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0404.1987.tb03582.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042573195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/114.5.2283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045332348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/syn.890090107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049173379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2396(199603)22:3<239::aid-syn6>3.0.co;2-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052502105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/syn.890200405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052505422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc960029l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055156044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc960029l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055156044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ic00080a022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055541333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja00149a039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055709606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm00033a010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055933155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm00037a004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055933264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm00210a013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055938795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm00210a014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055938796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm960532j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055957834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm960532j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055957834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1948034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062514561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076961046", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.11-09-02703.1991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077334883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081925199", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082509077", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082843390", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082852630", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082900264", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083016770", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083016796", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1997-04", 
    "datePublishedReg": "1997-04-01", 
    "description": "Technetium-99m is the most commonly used radionuclide in routine nuclear medicine imaging procedures. Development of 99mTc-labeled receptor-specific imaging agents for studying the central nervous system is potentially useful for evaluation of brain function in normal and disease states. A novel 99mTc-labeled tropane derivative, [99mTc]TRODAT-1, which is useful as a potential CNS dopamine transporter imaging agent, was evaluated and characterized. After i. v. injection into rats, [99mTc]TRODAT-1 displayed specific brain uptake in the rat striatal region (striatum-cerebellum/cerebellum ratio 1.8 at 60 min), where dopamine neurons are concentrated. The specific striatal uptake could be blocked by pretreating rats with a dose of competing dopamine transporter ligand, beta-CIT (or RTI-55, i.v., 1 mg/kg). However, the specific striatal uptake of [99mTc]TRODAT-1 was not affected by co-injection of excess free ligand (TRODAT-1, up to 200 microg per rat) or by pretreating the rats with haloperidol (i.v., 1 mg/kg). The specific uptake in striatal regions of rats that had prior 6-hydroxydopamine lesion in the substantia nigra area showed a dramatic reduction. The radioactive material recovered from the rat striatal homogenates at 60 min after i.v. injection of [99mTc]TRODAT-1 showed primarily the original compound (>95%), a good indication of in vivo stability in brain tissue. Similar and comparable organ distribution patterns and brain regional uptakes of [99mTc]TRODAT-1 were obtained for male and female rats. Ex vivo autoradiography results of rat brain sections further confirmed the high uptake and retention of [99mTc]TRODAT-1 in the striatal region. In vitro binding studies measuring the affinity to dopamine transporters for the free ligand, TRODAT-1, and a nonradioactive rhenium derivative, Re-TRODAT-1, showed Ki values of 9.7 nM and 14.1 nM, respectively. Behavioral studies in rats using the free ligand, TRODAT-1 and Re-TRODAT-1 indicated that, unlike other tropane derivatives, they displayed no effect on locomotor activity, suggesting low toxicity. These results strongly support the conclusions that this novel 99mTc radioligand binds selectively to dopamine transporters in the brain and that is is potentially useful for in vivo assessment of the loss of dopamine neurons in Parkinson's and other neurodegenerative diseases.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00881808", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2554807", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2556252", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1297401", 
        "issn": [
          "1619-7070", 
          "1619-7089"
        ], 
        "name": "European Journal of Nuclear Medicine and Molecular Imaging", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "24"
      }
    ], 
    "name": "[99mTc]TRODAT-1: A novel technetium-99m complex as a dopamine transporter imaging agent", 
    "pagination": "372-380", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5c037926e05743160829fccdbc56c66c6bbbfc2afb9d0b4d914b5ae78e39a7fa"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9096087"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7606882"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00881808"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1019311623"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00881808", 
      "https://app.dimensions.ai/details/publication/pub.1019311623"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000495.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF00881808"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00881808'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00881808'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00881808'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00881808'


 

This table displays all metadata directly associated to this object as RDF triples.

329 TRIPLES      21 PREDICATES      90 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00881808 schema:about N0f5dd5e0434348a7b843a9bee9ebf1c0
2 N13fd5edc130f4fb8a340a3eb4b4b231d
3 N186503d0dd3845b4bc8e9d2dcd856679
4 N475bda5f63ec46049341e261ecf700fa
5 N47dffdf1b8b9435ba6dc9435057bd53b
6 N4e580566f9934e5c9db6726e33950a47
7 N4f8de86ec93c4690b8c44f2fcdb5a9d4
8 N508ad24655d748248b31b1472db96af5
9 N8e7e44ceb6f94fccb358ff16a5765f11
10 N924faa3ac30b4063ace6723febd8eba5
11 N975d7fac34b84d79bf82923e79da16e4
12 N98b30b8938e04cd78b29d9c62ebff995
13 Na1ea3dbc5659459f87e5b21c1709e1de
14 Na9597af2323d417ab43ae2145f938bb5
15 Na9db9a4452e54f11ab7385475393761d
16 Nb7c94f53cd7c44dbb045ed3d1fd660e2
17 Nda41ece4132f4caf9393ccef5cb196ce
18 Nfa8c888776a149b385f498088ac2ff46
19 Nfc83c7eb08f24f44bd402345740997b6
20 anzsrc-for:11
21 anzsrc-for:1109
22 schema:author N7c9b126cf00c4b6483462971febc600f
23 schema:citation sg:pub.10.1007/bf01253106
24 sg:pub.10.1007/bf01254479
25 sg:pub.10.1007/bf01254571
26 sg:pub.10.1007/bf02244916
27 https://app.dimensions.ai/details/publication/pub.1076961046
28 https://app.dimensions.ai/details/publication/pub.1081925199
29 https://app.dimensions.ai/details/publication/pub.1082509077
30 https://app.dimensions.ai/details/publication/pub.1082843390
31 https://app.dimensions.ai/details/publication/pub.1082852630
32 https://app.dimensions.ai/details/publication/pub.1082900264
33 https://app.dimensions.ai/details/publication/pub.1083016770
34 https://app.dimensions.ai/details/publication/pub.1083016796
35 https://doi.org/10.1002/(sici)1098-2396(199603)22:3<239::aid-syn6>3.0.co;2-d
36 https://doi.org/10.1002/(sici)1098-2396(199611)24:3<273::aid-syn10>3.0.co;2-y
37 https://doi.org/10.1002/ana.410340331
38 https://doi.org/10.1002/ana.410380407
39 https://doi.org/10.1002/syn.890040412
40 https://doi.org/10.1002/syn.890090107
41 https://doi.org/10.1002/syn.890100210
42 https://doi.org/10.1002/syn.890120203
43 https://doi.org/10.1002/syn.890200405
44 https://doi.org/10.1016/0003-2697(80)90515-1
45 https://doi.org/10.1016/0006-8993(84)91280-0
46 https://doi.org/10.1016/0006-8993(95)00611-s
47 https://doi.org/10.1016/0969-8051(94)90004-3
48 https://doi.org/10.1016/0969-8051(94)90009-4
49 https://doi.org/10.1021/bc960029l
50 https://doi.org/10.1021/ic00080a022
51 https://doi.org/10.1021/ja00149a039
52 https://doi.org/10.1021/jm00033a010
53 https://doi.org/10.1021/jm00037a004
54 https://doi.org/10.1021/jm00210a013
55 https://doi.org/10.1021/jm00210a014
56 https://doi.org/10.1021/jm960532j
57 https://doi.org/10.1038/jcbfm.1988.64
58 https://doi.org/10.1073/pnas.90.24.11965
59 https://doi.org/10.1093/brain/114.5.2283
60 https://doi.org/10.1111/j.1600-0404.1987.tb03582.x
61 https://doi.org/10.1126/science.1948034
62 https://doi.org/10.1159/000117169
63 https://doi.org/10.1159/000117341
64 https://doi.org/10.1523/jneurosci.11-09-02703.1991
65 schema:datePublished 1997-04
66 schema:datePublishedReg 1997-04-01
67 schema:description Technetium-99m is the most commonly used radionuclide in routine nuclear medicine imaging procedures. Development of 99mTc-labeled receptor-specific imaging agents for studying the central nervous system is potentially useful for evaluation of brain function in normal and disease states. A novel 99mTc-labeled tropane derivative, [99mTc]TRODAT-1, which is useful as a potential CNS dopamine transporter imaging agent, was evaluated and characterized. After i. v. injection into rats, [99mTc]TRODAT-1 displayed specific brain uptake in the rat striatal region (striatum-cerebellum/cerebellum ratio 1.8 at 60 min), where dopamine neurons are concentrated. The specific striatal uptake could be blocked by pretreating rats with a dose of competing dopamine transporter ligand, beta-CIT (or RTI-55, i.v., 1 mg/kg). However, the specific striatal uptake of [99mTc]TRODAT-1 was not affected by co-injection of excess free ligand (TRODAT-1, up to 200 microg per rat) or by pretreating the rats with haloperidol (i.v., 1 mg/kg). The specific uptake in striatal regions of rats that had prior 6-hydroxydopamine lesion in the substantia nigra area showed a dramatic reduction. The radioactive material recovered from the rat striatal homogenates at 60 min after i.v. injection of [99mTc]TRODAT-1 showed primarily the original compound (>95%), a good indication of in vivo stability in brain tissue. Similar and comparable organ distribution patterns and brain regional uptakes of [99mTc]TRODAT-1 were obtained for male and female rats. Ex vivo autoradiography results of rat brain sections further confirmed the high uptake and retention of [99mTc]TRODAT-1 in the striatal region. In vitro binding studies measuring the affinity to dopamine transporters for the free ligand, TRODAT-1, and a nonradioactive rhenium derivative, Re-TRODAT-1, showed Ki values of 9.7 nM and 14.1 nM, respectively. Behavioral studies in rats using the free ligand, TRODAT-1 and Re-TRODAT-1 indicated that, unlike other tropane derivatives, they displayed no effect on locomotor activity, suggesting low toxicity. These results strongly support the conclusions that this novel 99mTc radioligand binds selectively to dopamine transporters in the brain and that is is potentially useful for in vivo assessment of the loss of dopamine neurons in Parkinson's and other neurodegenerative diseases.
68 schema:genre research_article
69 schema:inLanguage en
70 schema:isAccessibleForFree false
71 schema:isPartOf N06d6eb872f3d41518deff1c80cbb0380
72 N0c33890e332c4ca6a12720fa37bd6ac6
73 sg:journal.1297401
74 schema:name [99mTc]TRODAT-1: A novel technetium-99m complex as a dopamine transporter imaging agent
75 schema:pagination 372-380
76 schema:productId N22f0fb3211684b41aebe91bfe9ef80eb
77 N24ff72a1c5634e95a369125bb598ba8e
78 N2e551e88863a4dc29249b5b3138766b3
79 N83f5d7776a9044e586d813c3016bc587
80 Nd342761eb49744a89cc6266556abfc24
81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019311623
82 https://doi.org/10.1007/bf00881808
83 schema:sdDatePublished 2019-04-11T00:12
84 schema:sdLicense https://scigraph.springernature.com/explorer/license/
85 schema:sdPublisher Ned3b3edbe348422592df223bbdf506be
86 schema:url http://link.springer.com/10.1007/BF00881808
87 sgo:license sg:explorer/license/
88 sgo:sdDataset articles
89 rdf:type schema:ScholarlyArticle
90 N0643090631d642b5bf5d5cf9e9f822d7 rdf:first sg:person.0615735606.55
91 rdf:rest rdf:nil
92 N06d6eb872f3d41518deff1c80cbb0380 schema:volumeNumber 24
93 rdf:type schema:PublicationVolume
94 N0c33890e332c4ca6a12720fa37bd6ac6 schema:issueNumber 4
95 rdf:type schema:PublicationIssue
96 N0f5dd5e0434348a7b843a9bee9ebf1c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Male
98 rdf:type schema:DefinedTerm
99 N136764170b534473aa0420b05eb3a793 rdf:first sg:person.01217161223.03
100 rdf:rest N92479c1a4fa94a46a075e4a301e2b1cb
101 N13fd5edc130f4fb8a340a3eb4b4b231d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Dopamine
103 rdf:type schema:DefinedTerm
104 N186503d0dd3845b4bc8e9d2dcd856679 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Brain
106 rdf:type schema:DefinedTerm
107 N22f0fb3211684b41aebe91bfe9ef80eb schema:name doi
108 schema:value 10.1007/bf00881808
109 rdf:type schema:PropertyValue
110 N24ff72a1c5634e95a369125bb598ba8e schema:name dimensions_id
111 schema:value pub.1019311623
112 rdf:type schema:PropertyValue
113 N2e551e88863a4dc29249b5b3138766b3 schema:name pubmed_id
114 schema:value 9096087
115 rdf:type schema:PropertyValue
116 N475bda5f63ec46049341e261ecf700fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Rats, Sprague-Dawley
118 rdf:type schema:DefinedTerm
119 N47dffdf1b8b9435ba6dc9435057bd53b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Motor Activity
121 rdf:type schema:DefinedTerm
122 N4e580566f9934e5c9db6726e33950a47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Autoradiography
124 rdf:type schema:DefinedTerm
125 N4f8de86ec93c4690b8c44f2fcdb5a9d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Carrier Proteins
127 rdf:type schema:DefinedTerm
128 N508ad24655d748248b31b1472db96af5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Animals
130 rdf:type schema:DefinedTerm
131 N7c9b126cf00c4b6483462971febc600f rdf:first sg:person.01145435671.41
132 rdf:rest N136764170b534473aa0420b05eb3a793
133 N80d9176c58634f1b8bff10aad247ff42 rdf:first sg:person.01235331147.65
134 rdf:rest N945ef7358a61419e99ae65c82549dd12
135 N83f5d7776a9044e586d813c3016bc587 schema:name nlm_unique_id
136 schema:value 7606882
137 rdf:type schema:PropertyValue
138 N8d514660ca2448f8b105350b6b50d7cf rdf:first sg:person.01062136247.37
139 rdf:rest N0643090631d642b5bf5d5cf9e9f822d7
140 N8e7e44ceb6f94fccb358ff16a5765f11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Membrane Glycoproteins
142 rdf:type schema:DefinedTerm
143 N92479c1a4fa94a46a075e4a301e2b1cb rdf:first sg:person.0764777622.24
144 rdf:rest Nc6f0abb632b0438f960a97724ba7fd1f
145 N924faa3ac30b4063ace6723febd8eba5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Nerve Tissue Proteins
147 rdf:type schema:DefinedTerm
148 N945ef7358a61419e99ae65c82549dd12 rdf:first sg:person.01323731720.06
149 rdf:rest N99bb2e510fcd4d08a60e298b10b55741
150 N975d7fac34b84d79bf82923e79da16e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Organotechnetium Compounds
152 rdf:type schema:DefinedTerm
153 N98b30b8938e04cd78b29d9c62ebff995 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Tomography, Emission-Computed, Single-Photon
155 rdf:type schema:DefinedTerm
156 N99bb2e510fcd4d08a60e298b10b55741 rdf:first sg:person.01022556575.53
157 rdf:rest N8d514660ca2448f8b105350b6b50d7cf
158 Na1ea3dbc5659459f87e5b21c1709e1de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Rats
160 rdf:type schema:DefinedTerm
161 Na9597af2323d417ab43ae2145f938bb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Membrane Transport Proteins
163 rdf:type schema:DefinedTerm
164 Na9db9a4452e54f11ab7385475393761d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Female
166 rdf:type schema:DefinedTerm
167 Nb7c94f53cd7c44dbb045ed3d1fd660e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Sex Factors
169 rdf:type schema:DefinedTerm
170 Nc6f0abb632b0438f960a97724ba7fd1f rdf:first sg:person.01045627611.38
171 rdf:rest N80d9176c58634f1b8bff10aad247ff42
172 Nd342761eb49744a89cc6266556abfc24 schema:name readcube_id
173 schema:value 5c037926e05743160829fccdbc56c66c6bbbfc2afb9d0b4d914b5ae78e39a7fa
174 rdf:type schema:PropertyValue
175 Nda41ece4132f4caf9393ccef5cb196ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Dopamine Plasma Membrane Transport Proteins
177 rdf:type schema:DefinedTerm
178 Ned3b3edbe348422592df223bbdf506be schema:name Springer Nature - SN SciGraph project
179 rdf:type schema:Organization
180 Nfa8c888776a149b385f498088ac2ff46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Tissue Distribution
182 rdf:type schema:DefinedTerm
183 Nfc83c7eb08f24f44bd402345740997b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Tropanes
185 rdf:type schema:DefinedTerm
186 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
187 schema:name Medical and Health Sciences
188 rdf:type schema:DefinedTerm
189 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
190 schema:name Neurosciences
191 rdf:type schema:DefinedTerm
192 sg:grant.2554807 http://pending.schema.org/fundedItem sg:pub.10.1007/bf00881808
193 rdf:type schema:MonetaryGrant
194 sg:grant.2556252 http://pending.schema.org/fundedItem sg:pub.10.1007/bf00881808
195 rdf:type schema:MonetaryGrant
196 sg:journal.1297401 schema:issn 1619-7070
197 1619-7089
198 schema:name European Journal of Nuclear Medicine and Molecular Imaging
199 rdf:type schema:Periodical
200 sg:person.01022556575.53 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
201 schema:familyName Mu
202 schema:givenName Mu
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022556575.53
204 rdf:type schema:Person
205 sg:person.01045627611.38 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
206 schema:familyName Meegalla
207 schema:givenName Sanath K.
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045627611.38
209 rdf:type schema:Person
210 sg:person.01062136247.37 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
211 schema:familyName Lucki
212 schema:givenName Irwin
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062136247.37
214 rdf:type schema:Person
215 sg:person.01145435671.41 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
216 schema:familyName Kung
217 schema:givenName Mei-Ping
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145435671.41
219 rdf:type schema:Person
220 sg:person.01217161223.03 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
221 schema:familyName Stevenson
222 schema:givenName D. Andrew
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217161223.03
224 rdf:type schema:Person
225 sg:person.01235331147.65 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
226 schema:familyName Beckwith
227 schema:givenName Andrew
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235331147.65
229 rdf:type schema:Person
230 sg:person.01323731720.06 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
231 schema:familyName Essman
232 schema:givenName William D.
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323731720.06
234 rdf:type schema:Person
235 sg:person.0615735606.55 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
236 schema:familyName Kung
237 schema:givenName Hank F.
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615735606.55
239 rdf:type schema:Person
240 sg:person.0764777622.24 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
241 schema:familyName Plössl
242 schema:givenName Karl
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764777622.24
244 rdf:type schema:Person
245 sg:pub.10.1007/bf01253106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031825778
246 https://doi.org/10.1007/bf01253106
247 rdf:type schema:CreativeWork
248 sg:pub.10.1007/bf01254479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026914665
249 https://doi.org/10.1007/bf01254479
250 rdf:type schema:CreativeWork
251 sg:pub.10.1007/bf01254571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023163508
252 https://doi.org/10.1007/bf01254571
253 rdf:type schema:CreativeWork
254 sg:pub.10.1007/bf02244916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017628568
255 https://doi.org/10.1007/bf02244916
256 rdf:type schema:CreativeWork
257 https://app.dimensions.ai/details/publication/pub.1076961046 schema:CreativeWork
258 https://app.dimensions.ai/details/publication/pub.1081925199 schema:CreativeWork
259 https://app.dimensions.ai/details/publication/pub.1082509077 schema:CreativeWork
260 https://app.dimensions.ai/details/publication/pub.1082843390 schema:CreativeWork
261 https://app.dimensions.ai/details/publication/pub.1082852630 schema:CreativeWork
262 https://app.dimensions.ai/details/publication/pub.1082900264 schema:CreativeWork
263 https://app.dimensions.ai/details/publication/pub.1083016770 schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1083016796 schema:CreativeWork
265 https://doi.org/10.1002/(sici)1098-2396(199603)22:3<239::aid-syn6>3.0.co;2-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1052502105
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1002/(sici)1098-2396(199611)24:3<273::aid-syn10>3.0.co;2-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1042470140
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1002/ana.410340331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004318172
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1002/ana.410380407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022216822
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1002/syn.890040412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041932871
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1002/syn.890090107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049173379
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1002/syn.890100210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018012474
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1002/syn.890120203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012005644
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1002/syn.890200405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052505422
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/0003-2697(80)90515-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007065635
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/0006-8993(84)91280-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023043817
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/0006-8993(95)00611-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1041728880
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/0969-8051(94)90004-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010956551
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/0969-8051(94)90009-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012294328
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1021/bc960029l schema:sameAs https://app.dimensions.ai/details/publication/pub.1055156044
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1021/ic00080a022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055541333
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1021/ja00149a039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055709606
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1021/jm00033a010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055933155
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1021/jm00037a004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055933264
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1021/jm00210a013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055938795
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1021/jm00210a014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055938796
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1021/jm960532j schema:sameAs https://app.dimensions.ai/details/publication/pub.1055957834
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1038/jcbfm.1988.64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017572287
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1073/pnas.90.24.11965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006690895
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1093/brain/114.5.2283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045332348
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1111/j.1600-0404.1987.tb03582.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042573195
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1126/science.1948034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062514561
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1159/000117169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037826085
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1159/000117341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041981898
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1523/jneurosci.11-09-02703.1991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077334883
324 rdf:type schema:CreativeWork
325 https://www.grid.ac/institutes/grid.25879.31 schema:alternateName University of Pennsylvania
326 schema:name Department of Pharmacology, University of Pennsylvania, Philadelphia, USA
327 Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
328 Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, 19104, Philadelphia, PA, USA
329 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...