Phase II evaluation of didemnin B in hormonally refractory metastatic prostate cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-06

AUTHORS

Stephen K. Williamson, Michael K. Wolf, Mario A. Eisenberger, Mark O'Rourke, William Brannon, E. David Crawford

ABSTRACT

Didemnin B, a dipsipeptide isolated from the Caribbean tunicate Trididemnum with antitumor and antiviral activity was evaluated in a phase II trial in the treatment of metastatic, hormonally refractory adenocarcinoma of the prostate. Thirteen patients were treated with didemnin B at 3.5 mg/m2 and 20 patients were treated at 6.3 mg/m2 intravenously every 28 days. Response was assessed every 8 weeks. Of 32 evaluable patients there was one partial response for an overall response rate of 3% (95% confidence interval of 0.1-16%). The most common toxicities were nausea, vomiting, and diarrhea. Serious cardiac and pulmonary toxicities were also noted. This drug does not appear to warrant further evaluation in this disease as a single agent. More... »

PAGES

167-170

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00872867

DOI

http://dx.doi.org/10.1007/bf00872867

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011446266

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8617581


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