DNA vaccines: safety and efficacy issues View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-06

AUTHORS

Dennis M. Klinman, Mitsuhiro Takeno, Motohide Ichino, Mili Gu, Galina Yamshchikov, Gil Mor, Jacqueline Conover

ABSTRACT

DNA technology has been harnessed to produce a variety of plasmid-based vaccines designed to prevent viral, bacterial and parasitic infections. The rapid adoption and implementation of this novel vaccine strategy carries with it important safety and efficacy concerns. This review will focus on whether DNA vaccines (1) are likely to induce systemic or organ-specific autoimmune disease, (2) have the potential to induce tolerance rather than immunity, and (3) are as effective in individuals with depressed immune function as they are in healthy adults. More... »

PAGES

245-256

References to SciGraph publications

Journal

TITLE

Seminars in Immunopathology

ISSUE

2

VOLUME

19

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00870272

    DOI

    http://dx.doi.org/10.1007/bf00870272

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001524893

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9406350


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