Developmental analysis of a temperature-sensitive melanotic tumor mutant inDrosophila melanogaster View Full Text


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Article Info

DATE

1980-10

AUTHORS

T. M. Rizki, Rose M. Rizki

ABSTRACT

A sex-linked, temperature-sensitive melanotic tumor mutation inDrosophila melanogaster, tu (1) Sz ts, was mapped at 34.3±and localized to bands 10A10-11 of the polytene chromosomes. At 26°Ctu-Sz ts larvae develop melanotic tumors whereas 18°C is non-permissive for tumor formation. Tumorigenesis at 26°C involves the encapsulation of abnormal caudal fat body regions by precociously differentiated hemocytes. Low temperature blocks the development of the abnormal adipose cells and the overlying aberrant tissue surfaces but does not inhibit precocious differentiation of the hemocytes to the lamellocytic form. This phenotypic difference at the two temperatures indicates that lamellocyte encapsulation to form melanotic tumors is directed against abnormal tissue surfaces. On the basis of these observations and an earlier study (Rizki and Rizki 1979) we propose that hereditary melanotic tumors inD. melanogaster are a calss of autoimmune disorders in which affected tissue surfaces arouse the body's cellmediated defense response. More... »

PAGES

197-206

References to SciGraph publications

  • 1978. The Role of Hemocytes in Melanotic Tumor Formation in INVERTEBRATE MODELS FOR BIOMEDICAL RESEARCH
  • 1974-05. Basement membrane abnormalities in melanotic tumor formation ofDrosophila in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 1953-09. The histogenesis of a new tumor in Drosophila melanogaster, and a comparison with tumors of five other stocks in ZEITSCHRIFT FÜR INDUKTIVE ABSTAMMUNGS- UND VERERBUNGSLEHRE
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    URI

    http://scigraph.springernature.com/pub.10.1007/bf00868678

    DOI

    http://dx.doi.org/10.1007/bf00868678

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1027158351

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28305175


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