Iphosphamide-induced nephrotoxicity in children View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-03

AUTHORS

Richard Shore, Mark Greenberg, Dennis Geary, Gideon Koren

ABSTRACT

The nephrotoxic potential of iphosphamide was evaluated in a retrospective analysis of all children receiving the drug at The Hospital for Sick Children in Toronto. The 25 children exhibiting nephrotoxicity did not receive more cycles or higher doses per square metre than the 78 with normal renal function. Similarly, the two groups received comparable doses and number of cycles of sodium 2-mercaptoethanesulphonate, and had similar rates of exposure to nephrotoxic drugs (except for cis-platinum). Children exhibiting nephrotoxicity were significantly younger (78.1 +/- 64.1 months) than those having normal kidney function (103.8 +/- 66.6 months) (P less than 0.05). Children exhibiting nephrotoxicity were more likely to have received cis-platinum prior to the iphosphamide (10/25, 40%) than those with normal renal function (14/73, 18%) (P less than 0.05). Nephrotoxicity was associated with a significant effect on growth. Careful follow-up of renal function should take place in children receiving iphosphamide, with special attention paid to children younger than 5 years of age and those who have received cis-platinum. More... »

PAGES

162-165

References to SciGraph publications

  • 1989-02. Fanconi syndrome after ifosfamide in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 1989-07. Toxicity of high-dose ifosfamide in children in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00866300

    DOI

    http://dx.doi.org/10.1007/bf00866300

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1027478341

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1571213


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    156 schema:name Division of Hematology-Oncology Department of Pediatrics and Research Institute, The Hospital for Sick Children, 555 University Avenue, M5G 1X8, Toronto, ON, Canada
    157 Division of Nephrology Department of Pediatrics and Research Institute, The Hospital for Sick Children, 555 University Avenue, M5G 1X8, Toronto, ON, Canada
    158 rdf:type schema:Organization
     




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