Expression of cytokines and growth factors in human glomerulonephritides View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-08

AUTHORS

Rüdiger Waldherr, Irene L. Noronha, Zofia Niemir, Cornelia Krüger, Henning Stein, Gariele Stumm

ABSTRACT

Numerous experimental studies point to the potential role of cytokines and growth factors in the pathogenesis of renal disease. However, from the various autocrine and paracrine mediators identified in vitro and in animal models, so far only a few have been demonstrated in selected human glomerulopathies. We examined two types of glomerulonephritis (GN): extracapillary GN with anti-neutrophil cytoplasmic autoantibodies (ANCA), an example of an acute form of GN, and mesangial IgA GN, usually a chronic form of GN, with immunocytochemistry, in situ hybridization and the polymerase chain reaction. Normal renal tissue from tumour nephrectomies served as a control. In ANCA-positive GN with active renal lesions (crescents, glomerular and vascular necrosis), infiltrating mononuclear cells in glomeruli and in the interstitium expressed interleukin (IL)-1β, tumour necrosis factor (TNF)-α, IL-2, interferon (IFN)-γ, platelet-derived growth factor (PDGF) and transforming growth factor (TGF)-β. Cytokine expression was also observed in activated resident cells, including endothelial cells, capsular epithelial cells, smooth muscle cells of vessel walls, fibroblasts and some tubular epithelial cells. In addition, we noted an increase in the cytokine and growth factor receptors TNF-R, IL-1R type II, IL-2R, IFN-γR and PDGFβ-R. In contrast, in mesangial IgA-GN, IL-1β, TNF-α, IFN-γ and IL-2 were usually absent in glomeruli. Mesangial expansion in this disorder was accompanied by an increased expression of PDGF, PDGFβ-R, TGF-β and IL-6 in mesangial areas. In both conditions a good correlation was observed between cytokine expression at the mRNA (in situ hybridization) and protein level (immunocytochemistry). These results demonstrate that different cytokine and growth factor patterns are expressed in the various forms of GN, and suggest that the local production of these peptides plays an important role in the pathogenesis and progression of human glomerulonephritides. More... »

PAGES

471-478

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00857578

DOI

http://dx.doi.org/10.1007/bf00857578

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003197497

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8398664


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Antineutrophil Cytoplasmic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autoantibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glomerular Mesangium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glomerulonephritis, IGA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glomerulonephritis, Membranoproliferative", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Growth Substances", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin G", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Hybridization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vasculitis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D-69120, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D-69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Waldherr", 
        "givenName": "R\u00fcdiger", 
        "id": "sg:person.01041273513.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041273513.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D-69120, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D-69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Noronha", 
        "givenName": "Irene L.", 
        "id": "sg:person.010466234567.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010466234567.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D-69120, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D-69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Niemir", 
        "givenName": "Zofia", 
        "id": "sg:person.01275311560.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275311560.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D-69120, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D-69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kr\u00fcger", 
        "givenName": "Cornelia", 
        "id": "sg:person.01055055446.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055055446.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D-69120, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D-69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stein", 
        "givenName": "Henning", 
        "id": "sg:person.0612177767.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612177767.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D-69120, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D-69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stumm", 
        "givenName": "Gariele", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00180754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007623404", 
          "https://doi.org/10.1007/bf00180754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00180757", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006817369", 
          "https://doi.org/10.1007/bf00180757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00180756", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041620343", 
          "https://doi.org/10.1007/bf00180756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/346371a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000833539", 
          "https://doi.org/10.1038/346371a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01649318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027546433", 
          "https://doi.org/10.1007/bf01649318"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1993-08", 
    "datePublishedReg": "1993-08-01", 
    "description": "Numerous experimental studies point to the potential role of cytokines and growth factors in the pathogenesis of renal disease. However, from the various autocrine and paracrine mediators identified in vitro and in animal models, so far only a few have been demonstrated in selected human glomerulopathies. We examined two types of glomerulonephritis (GN): extracapillary GN with anti-neutrophil cytoplasmic autoantibodies (ANCA), an example of an acute form of GN, and mesangial IgA GN, usually a chronic form of GN, with immunocytochemistry, in situ hybridization and the polymerase chain reaction. Normal renal tissue from tumour nephrectomies served as a control. In ANCA-positive GN with active renal lesions (crescents, glomerular and vascular necrosis), infiltrating mononuclear cells in glomeruli and in the interstitium expressed interleukin (IL)-1\u03b2, tumour necrosis factor (TNF)-\u03b1, IL-2, interferon (IFN)-\u03b3, platelet-derived growth factor (PDGF) and transforming growth factor (TGF)-\u03b2. Cytokine expression was also observed in activated resident cells, including endothelial cells, capsular epithelial cells, smooth muscle cells of vessel walls, fibroblasts and some tubular epithelial cells. In addition, we noted an increase in the cytokine and growth factor receptors TNF-R, IL-1R type II, IL-2R, IFN-\u03b3R and PDGF\u03b2-R. In contrast, in mesangial IgA-GN, IL-1\u03b2, TNF-\u03b1, IFN-\u03b3 and IL-2 were usually absent in glomeruli. Mesangial expansion in this disorder was accompanied by an increased expression of PDGF, PDGF\u03b2-R, TGF-\u03b2 and IL-6 in mesangial areas. In both conditions a good correlation was observed between cytokine expression at the mRNA (in situ hybridization) and protein level (immunocytochemistry). These results demonstrate that different cytokine and growth factor patterns are expressed in the various forms of GN, and suggest that the local production of these peptides plays an important role in the pathogenesis and progression of human glomerulonephritides.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf00857578", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1097267", 
        "issn": [
          "0931-041X", 
          "1432-198X"
        ], 
        "name": "Pediatric Nephrology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "keywords": [
      "anti-neutrophil cytoplasmic autoantibodies", 
      "platelet-derived growth factor", 
      "growth factor", 
      "cytokine expression", 
      "IL-2", 
      "human glomerulonephritides", 
      "ANCA-positive glomerulonephritis", 
      "active renal lesions", 
      "mesangial IgA-GN", 
      "epithelial cells", 
      "forms of glomerulonephritis", 
      "types of glomerulonephritis", 
      "mesangial IgA glomerulonephritis", 
      "tumor necrosis factor", 
      "expression of cytokines", 
      "IL-1R type II", 
      "capsular epithelial cells", 
      "tubular epithelial cells", 
      "normal renal tissue", 
      "smooth muscle cells", 
      "cytoplasmic autoantibodies", 
      "IgA glomerulonephritis", 
      "renal disease", 
      "extracapillary glomerulonephritis", 
      "tumor nephrectomy", 
      "IgA-GN", 
      "mesangial expansion", 
      "renal lesions", 
      "chronic form", 
      "mononuclear cells", 
      "IL-1\u03b2", 
      "IL-6", 
      "IFN-\u03b3R", 
      "polymerase chain reaction", 
      "necrosis factor", 
      "IL-2R", 
      "renal tissue", 
      "glomerulonephritis", 
      "mesangial area", 
      "paracrine mediators", 
      "animal models", 
      "acute form", 
      "different cytokines", 
      "resident cells", 
      "cytokines", 
      "increased expression", 
      "muscle cells", 
      "human glomerulopathies", 
      "endothelial cells", 
      "protein levels", 
      "vessel wall", 
      "chain reaction", 
      "potential role", 
      "glomerulonephritides", 
      "growth factor patterns", 
      "TNF", 
      "pathogenesis", 
      "glomeruli", 
      "PDGF\u03b2", 
      "situ hybridization", 
      "local production", 
      "type II", 
      "cells", 
      "expression", 
      "numerous experimental studies", 
      "factor patterns", 
      "autoantibodies", 
      "nephrectomy", 
      "glomerulopathy", 
      "factors", 
      "interleukin", 
      "IFN", 
      "interferon", 
      "lesions", 
      "TGF", 
      "disease", 
      "autocrine", 
      "interstitium", 
      "progression", 
      "important role", 
      "immunocytochemistry", 
      "disorders", 
      "mediators", 
      "vitro", 
      "tissue", 
      "role", 
      "good correlation", 
      "fibroblasts", 
      "mRNA", 
      "peptides", 
      "levels", 
      "control", 
      "study", 
      "increase", 
      "contrast", 
      "correlation", 
      "hybridization", 
      "form", 
      "patterns", 
      "wall", 
      "addition", 
      "experimental study", 
      "types", 
      "area", 
      "production", 
      "results", 
      "reaction", 
      "conditions", 
      "model", 
      "expansion", 
      "example"
    ], 
    "name": "Expression of cytokines and growth factors in human glomerulonephritides", 
    "pagination": "471-478", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003197497"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00857578"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8398664"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00857578", 
      "https://app.dimensions.ai/details/publication/pub.1003197497"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T20:47", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_250.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf00857578"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00857578'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00857578'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00857578'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00857578'


 

This table displays all metadata directly associated to this object as RDF triples.

274 TRIPLES      21 PREDICATES      154 URIs      141 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00857578 schema:about N14ba88e1f07e412db17d6848450a69ac
2 N2ca5b69f329741c0825f9daefd019507
3 N2d28abc4280d4b29a4d9fa0fd5865571
4 N4061045a60904657abb2b31dd2272afb
5 N48e5ab7705294fb091dcda1f01b16fac
6 N72b0e6404f544eda93099d887a578a2d
7 N7ef69cb6f31f42c4b67b6e8c523fabf5
8 N9edd4c24abff4ace92e803feb24b8858
9 Nb8cac6fe3fb64d0ba68d2b8b5dde1742
10 Nc0bf6c6d5dd74e57b211e79ab3410e17
11 Ned9e0a71a0504e05950548441dc41c3e
12 Nfe0225e940a84e619644f43c9d74b904
13 anzsrc-for:11
14 anzsrc-for:1107
15 schema:author N73c04aa3e81b461a8857b2238c3b57b3
16 schema:citation sg:pub.10.1007/bf00180754
17 sg:pub.10.1007/bf00180756
18 sg:pub.10.1007/bf00180757
19 sg:pub.10.1007/bf01649318
20 sg:pub.10.1038/346371a0
21 schema:datePublished 1993-08
22 schema:datePublishedReg 1993-08-01
23 schema:description Numerous experimental studies point to the potential role of cytokines and growth factors in the pathogenesis of renal disease. However, from the various autocrine and paracrine mediators identified in vitro and in animal models, so far only a few have been demonstrated in selected human glomerulopathies. We examined two types of glomerulonephritis (GN): extracapillary GN with anti-neutrophil cytoplasmic autoantibodies (ANCA), an example of an acute form of GN, and mesangial IgA GN, usually a chronic form of GN, with immunocytochemistry, in situ hybridization and the polymerase chain reaction. Normal renal tissue from tumour nephrectomies served as a control. In ANCA-positive GN with active renal lesions (crescents, glomerular and vascular necrosis), infiltrating mononuclear cells in glomeruli and in the interstitium expressed interleukin (IL)-1β, tumour necrosis factor (TNF)-α, IL-2, interferon (IFN)-γ, platelet-derived growth factor (PDGF) and transforming growth factor (TGF)-β. Cytokine expression was also observed in activated resident cells, including endothelial cells, capsular epithelial cells, smooth muscle cells of vessel walls, fibroblasts and some tubular epithelial cells. In addition, we noted an increase in the cytokine and growth factor receptors TNF-R, IL-1R type II, IL-2R, IFN-γR and PDGFβ-R. In contrast, in mesangial IgA-GN, IL-1β, TNF-α, IFN-γ and IL-2 were usually absent in glomeruli. Mesangial expansion in this disorder was accompanied by an increased expression of PDGF, PDGFβ-R, TGF-β and IL-6 in mesangial areas. In both conditions a good correlation was observed between cytokine expression at the mRNA (in situ hybridization) and protein level (immunocytochemistry). These results demonstrate that different cytokine and growth factor patterns are expressed in the various forms of GN, and suggest that the local production of these peptides plays an important role in the pathogenesis and progression of human glomerulonephritides.
24 schema:genre article
25 schema:isAccessibleForFree false
26 schema:isPartOf N1d9acd03528d4219a007d4f98be07648
27 N5a5e0b6df7454d2ea993d959efac9e35
28 sg:journal.1097267
29 schema:keywords ANCA-positive glomerulonephritis
30 IFN
31 IFN-γR
32 IL-1R type II
33 IL-1β
34 IL-2
35 IL-2R
36 IL-6
37 IgA glomerulonephritis
38 IgA-GN
39 PDGFβ
40 TGF
41 TNF
42 active renal lesions
43 acute form
44 addition
45 animal models
46 anti-neutrophil cytoplasmic autoantibodies
47 area
48 autoantibodies
49 autocrine
50 capsular epithelial cells
51 cells
52 chain reaction
53 chronic form
54 conditions
55 contrast
56 control
57 correlation
58 cytokine expression
59 cytokines
60 cytoplasmic autoantibodies
61 different cytokines
62 disease
63 disorders
64 endothelial cells
65 epithelial cells
66 example
67 expansion
68 experimental study
69 expression
70 expression of cytokines
71 extracapillary glomerulonephritis
72 factor patterns
73 factors
74 fibroblasts
75 form
76 forms of glomerulonephritis
77 glomeruli
78 glomerulonephritides
79 glomerulonephritis
80 glomerulopathy
81 good correlation
82 growth factor
83 growth factor patterns
84 human glomerulonephritides
85 human glomerulopathies
86 hybridization
87 immunocytochemistry
88 important role
89 increase
90 increased expression
91 interferon
92 interleukin
93 interstitium
94 lesions
95 levels
96 local production
97 mRNA
98 mediators
99 mesangial IgA glomerulonephritis
100 mesangial IgA-GN
101 mesangial area
102 mesangial expansion
103 model
104 mononuclear cells
105 muscle cells
106 necrosis factor
107 nephrectomy
108 normal renal tissue
109 numerous experimental studies
110 paracrine mediators
111 pathogenesis
112 patterns
113 peptides
114 platelet-derived growth factor
115 polymerase chain reaction
116 potential role
117 production
118 progression
119 protein levels
120 reaction
121 renal disease
122 renal lesions
123 renal tissue
124 resident cells
125 results
126 role
127 situ hybridization
128 smooth muscle cells
129 study
130 tissue
131 tubular epithelial cells
132 tumor necrosis factor
133 tumor nephrectomy
134 type II
135 types
136 types of glomerulonephritis
137 vessel wall
138 vitro
139 wall
140 schema:name Expression of cytokines and growth factors in human glomerulonephritides
141 schema:pagination 471-478
142 schema:productId N3236e470dcd24b1ab14de3c6c7a8b3b2
143 N4e5d2ec68dbd4ff693c11b78bc7a4ffa
144 N968a88ee6ce640aeb49a9ef4c6be7b58
145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003197497
146 https://doi.org/10.1007/bf00857578
147 schema:sdDatePublished 2022-11-24T20:47
148 schema:sdLicense https://scigraph.springernature.com/explorer/license/
149 schema:sdPublisher Nded10f8ca82942fba77329cb3c61d03b
150 schema:url https://doi.org/10.1007/bf00857578
151 sgo:license sg:explorer/license/
152 sgo:sdDataset articles
153 rdf:type schema:ScholarlyArticle
154 N14ba88e1f07e412db17d6848450a69ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Immunoglobulin G
156 rdf:type schema:DefinedTerm
157 N1d9acd03528d4219a007d4f98be07648 schema:volumeNumber 7
158 rdf:type schema:PublicationVolume
159 N2ca5b69f329741c0825f9daefd019507 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Polymerase Chain Reaction
161 rdf:type schema:DefinedTerm
162 N2d28abc4280d4b29a4d9fa0fd5865571 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Growth Substances
164 rdf:type schema:DefinedTerm
165 N3236e470dcd24b1ab14de3c6c7a8b3b2 schema:name pubmed_id
166 schema:value 8398664
167 rdf:type schema:PropertyValue
168 N4061045a60904657abb2b31dd2272afb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Glomerulonephritis, Membranoproliferative
170 rdf:type schema:DefinedTerm
171 N48e5ab7705294fb091dcda1f01b16fac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Antibodies, Antineutrophil Cytoplasmic
173 rdf:type schema:DefinedTerm
174 N4e5d2ec68dbd4ff693c11b78bc7a4ffa schema:name dimensions_id
175 schema:value pub.1003197497
176 rdf:type schema:PropertyValue
177 N5a5e0b6df7454d2ea993d959efac9e35 schema:issueNumber 4
178 rdf:type schema:PublicationIssue
179 N72b0e6404f544eda93099d887a578a2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Autoantibodies
181 rdf:type schema:DefinedTerm
182 N73c04aa3e81b461a8857b2238c3b57b3 rdf:first sg:person.01041273513.06
183 rdf:rest Nbde99757cf124af4a87a711ffd5da77a
184 N7ef69cb6f31f42c4b67b6e8c523fabf5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Humans
186 rdf:type schema:DefinedTerm
187 N8ca7942fda4e45099dba7f34f0dd6fe2 rdf:first sg:person.0612177767.57
188 rdf:rest Nf571ee52fb6a43c2829299aa8973f760
189 N940c45f22942493a8331dfbb08460c76 schema:affiliation grid-institutes:grid.7700.0
190 schema:familyName Stumm
191 schema:givenName Gariele
192 rdf:type schema:Person
193 N968a88ee6ce640aeb49a9ef4c6be7b58 schema:name doi
194 schema:value 10.1007/bf00857578
195 rdf:type schema:PropertyValue
196 N99519f09710340b599cc8c69e0b21a2e rdf:first sg:person.01055055446.13
197 rdf:rest N8ca7942fda4e45099dba7f34f0dd6fe2
198 N9edd4c24abff4ace92e803feb24b8858 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Cytokines
200 rdf:type schema:DefinedTerm
201 Nb8cac6fe3fb64d0ba68d2b8b5dde1742 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Vasculitis
203 rdf:type schema:DefinedTerm
204 Nbde99757cf124af4a87a711ffd5da77a rdf:first sg:person.010466234567.54
205 rdf:rest Nf5239a7b1bbf4be3bfbc5cf13f10559c
206 Nc0bf6c6d5dd74e57b211e79ab3410e17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Glomerular Mesangium
208 rdf:type schema:DefinedTerm
209 Nded10f8ca82942fba77329cb3c61d03b schema:name Springer Nature - SN SciGraph project
210 rdf:type schema:Organization
211 Ned9e0a71a0504e05950548441dc41c3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Glomerulonephritis, IGA
213 rdf:type schema:DefinedTerm
214 Nf5239a7b1bbf4be3bfbc5cf13f10559c rdf:first sg:person.01275311560.89
215 rdf:rest N99519f09710340b599cc8c69e0b21a2e
216 Nf571ee52fb6a43c2829299aa8973f760 rdf:first N940c45f22942493a8331dfbb08460c76
217 rdf:rest rdf:nil
218 Nfe0225e940a84e619644f43c9d74b904 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name In Situ Hybridization
220 rdf:type schema:DefinedTerm
221 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
222 schema:name Medical and Health Sciences
223 rdf:type schema:DefinedTerm
224 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
225 schema:name Immunology
226 rdf:type schema:DefinedTerm
227 sg:journal.1097267 schema:issn 0931-041X
228 1432-198X
229 schema:name Pediatric Nephrology
230 schema:publisher Springer Nature
231 rdf:type schema:Periodical
232 sg:person.01041273513.06 schema:affiliation grid-institutes:grid.7700.0
233 schema:familyName Waldherr
234 schema:givenName Rüdiger
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041273513.06
236 rdf:type schema:Person
237 sg:person.010466234567.54 schema:affiliation grid-institutes:grid.7700.0
238 schema:familyName Noronha
239 schema:givenName Irene L.
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010466234567.54
241 rdf:type schema:Person
242 sg:person.01055055446.13 schema:affiliation grid-institutes:grid.7700.0
243 schema:familyName Krüger
244 schema:givenName Cornelia
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055055446.13
246 rdf:type schema:Person
247 sg:person.01275311560.89 schema:affiliation grid-institutes:grid.7700.0
248 schema:familyName Niemir
249 schema:givenName Zofia
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275311560.89
251 rdf:type schema:Person
252 sg:person.0612177767.57 schema:affiliation grid-institutes:grid.7700.0
253 schema:familyName Stein
254 schema:givenName Henning
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612177767.57
256 rdf:type schema:Person
257 sg:pub.10.1007/bf00180754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007623404
258 https://doi.org/10.1007/bf00180754
259 rdf:type schema:CreativeWork
260 sg:pub.10.1007/bf00180756 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041620343
261 https://doi.org/10.1007/bf00180756
262 rdf:type schema:CreativeWork
263 sg:pub.10.1007/bf00180757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006817369
264 https://doi.org/10.1007/bf00180757
265 rdf:type schema:CreativeWork
266 sg:pub.10.1007/bf01649318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027546433
267 https://doi.org/10.1007/bf01649318
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/346371a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000833539
270 https://doi.org/10.1038/346371a0
271 rdf:type schema:CreativeWork
272 grid-institutes:grid.7700.0 schema:alternateName Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D-69120, Heidelberg, Germany
273 schema:name Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D-69120, Heidelberg, Germany
274 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...