Somatic growth in corticosteroid-trated rats with passive Heymann nephritis —effects of recombinant human growth hormone on growth impariment View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-09

AUTHORS

Hiroshi Kawaguchi, Motoshi Hattori, Miyuki Kohno, Katsumi Ito, Naomi Hizuka, Kazue Takano

ABSTRACT

We evaluated the efficacy of recombinant human growth hormone (r-hGH) on corticosteroid (CS)-induced growth-impaired rats with proteinuria (passive Heymann nephritis). R-hGH (2 IU twice daily) improved growth in rats treated with 20 mg/kg per day of prednisolone succinate in our 4-week study. Although plasma hGH was significantly increased in rats treated with r-HGH, plasma insulin-like growth factor-1 levels were not different between treated and untreated rats. The food utilization rate was significantly improved by r-hGH. R-hGH did not affect proteinuria, renal function, or calcium and phosphate metabolism. Our results suggest that r-hGH may be effective in improving growth impairment due to CS administration. More... »

PAGES

603-606

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00856650

DOI

http://dx.doi.org/10.1007/bf00856650

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039619732

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1911147


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