Ontology type: schema:ScholarlyArticle
1993-06
AUTHORSMoin A. Saleem, David V. Milford, Faro Raafat, Richard H. R. White
ABSTRACTMalakoplakia is an inflammatory condition associated with persisting bacterial antigen in macrophages and characterized histologically by the Michaelis-Gutmann body, containing bacterial fragments. We review the pathogenesis of malakoplakia and report a novel form of treatment successfully used in an 8-week-old infant with bilateral renal malakoplakia. The patient presented with an acute Escherichia coli urinary tract infection and enlarged kidneys. Antibiotic regimes were ineffective, but once the diagnosis was made treatment was changed to an immunosuppressive regime of prednisolone and azathioprine, to which she responded promptly. Renal malakoplakia should be considered in any patient with a urinary tract infection unresponsive to antibiotics and enlarged kidneys. Although a large proportion of patients with malakoplakia have an underlying systemic disorder, which may account for their abnormal macrophage function, the rest demonstrate either an isolated macrophage defect or no detectable anomaly at all. It is in this latter group we suggest that an immunomodulating regime can be curative. More... »
PAGES256-258
http://scigraph.springernature.com/pub.10.1007/bf00853212
DOIhttp://dx.doi.org/10.1007/bf00853212
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1016459141
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/8518093
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Azathioprine",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Escherichia coli Infections",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hypertrophy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Infant",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Malacoplakia",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Nephritis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prednisolone",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Urinary Tract Infections",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Birmingham Children's Hospital",
"id": "https://www.grid.ac/institutes/grid.415246.0",
"name": [
"Department of Nephrology, The Children's Hospital, Ladywood Middleway, B168ET, Birmingham, UK"
],
"type": "Organization"
},
"familyName": "Saleem",
"givenName": "Moin A.",
"id": "sg:person.01314662726.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314662726.22"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Birmingham Children's Hospital",
"id": "https://www.grid.ac/institutes/grid.415246.0",
"name": [
"Department of Nephrology, The Children's Hospital, Ladywood Middleway, B168ET, Birmingham, UK"
],
"type": "Organization"
},
"familyName": "Milford",
"givenName": "David V.",
"id": "sg:person.01064602402.16",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064602402.16"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Birmingham Children's Hospital",
"id": "https://www.grid.ac/institutes/grid.415246.0",
"name": [
"Department of Pahtology, The Children's Hospital, Ladywood Middleway, B168ET, Birmingham, UK"
],
"type": "Organization"
},
"familyName": "Raafat",
"givenName": "Faro",
"id": "sg:person.01142223464.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142223464.51"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Birmingham Children's Hospital",
"id": "https://www.grid.ac/institutes/grid.415246.0",
"name": [
"Department of Nephrology, The Children's Hospital, Ladywood Middleway, B168ET, Birmingham, UK"
],
"type": "Organization"
},
"familyName": "White",
"givenName": "Richard H. R.",
"id": "sg:person.013230114422.16",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013230114422.16"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/bf00439404",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002114169",
"https://doi.org/10.1007/bf00439404"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00439404",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002114169",
"https://doi.org/10.1007/bf00439404"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/15513819009067129",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011841032"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf02549899",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019244632",
"https://doi.org/10.1007/bf02549899"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf02549899",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019244632",
"https://doi.org/10.1007/bf02549899"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0046-8177(74)80066-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021351231"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0090-4295(77)90143-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021702016"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm197712292972601",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024724994"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/adc.60.3.254",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028191344"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf02560441",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029505583",
"https://doi.org/10.1007/bf02560441"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1007/bf02560441",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029505583"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/15513818309040671",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031747971"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf02564893",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031753567",
"https://doi.org/10.1007/bf02564893"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1007/bf02564893",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031753567"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1017/s0022215100116627",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034100687"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00007890-198102000-00003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042518654"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00007890-198102000-00003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042518654"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0090-4295(79)90436-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050756493"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/000992288502400802",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063563981"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/000992288502400802",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063563981"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074750604",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075356822",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078603730",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078786732",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079320725",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079541506",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080014261",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080110589",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080303535",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081364757",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081586030",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0022-5347(17)49975-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1081590064"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0022-5347(17)54940-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1082098439"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082150004",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082263066",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0022-5347(17)58489-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1082834692"
],
"type": "CreativeWork"
}
],
"datePublished": "1993-06",
"datePublishedReg": "1993-06-01",
"description": "Malakoplakia is an inflammatory condition associated with persisting bacterial antigen in macrophages and characterized histologically by the Michaelis-Gutmann body, containing bacterial fragments. We review the pathogenesis of malakoplakia and report a novel form of treatment successfully used in an 8-week-old infant with bilateral renal malakoplakia. The patient presented with an acute Escherichia coli urinary tract infection and enlarged kidneys. Antibiotic regimes were ineffective, but once the diagnosis was made treatment was changed to an immunosuppressive regime of prednisolone and azathioprine, to which she responded promptly. Renal malakoplakia should be considered in any patient with a urinary tract infection unresponsive to antibiotics and enlarged kidneys. Although a large proportion of patients with malakoplakia have an underlying systemic disorder, which may account for their abnormal macrophage function, the rest demonstrate either an isolated macrophage defect or no detectable anomaly at all. It is in this latter group we suggest that an immunomodulating regime can be curative.",
"genre": "research_article",
"id": "sg:pub.10.1007/bf00853212",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1097267",
"issn": [
"0931-041X",
"1432-198X"
],
"name": "Pediatric Nephrology",
"type": "Periodical"
},
{
"issueNumber": "3",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "7"
}
],
"name": "Renal parenchymal malakoplakia \u2014a case report and review of the literature",
"pagination": "256-258",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"4e6c19b9a09d8a9a3fe63016dd4bc725955de9a7fabb2fee422f72de0f53925a"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"8518093"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8708728"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/bf00853212"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1016459141"
]
}
],
"sameAs": [
"https://doi.org/10.1007/bf00853212",
"https://app.dimensions.ai/details/publication/pub.1016459141"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T20:39",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000480.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007/BF00853212"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00853212'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00853212'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00853212'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00853212'
This table displays all metadata directly associated to this object as RDF triples.
218 TRIPLES
21 PREDICATES
71 URIs
31 LITERALS
19 BLANK NODES