Role of specific iodothyronine-binding proteins in nucleo-cytoplasmic relations of thyroid hormones in liver cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1977-01

AUTHORS

Ya. Kh. Turakulov, M. Mirakhmedov, R. A. Yangunaev, D. Khamidkhodzhaeva

ABSTRACT

The role of specific iodothyronine-binding proteins of hepatocytes in the nucleo-cytoplasmic relations of thyroid hormones in rats was investigated under normal conditions, after thyroidectomy, and in experimental thyrotoxicosis. The concentration of hormone-binding sites in the cell was shown to depend on the extracellular level of thyroid hormones. The important role of cytosol hormone-binding proteins in the accumulation and intracellular distribution of thyroid hormones is emphasized. Cytosol tri-iodothyronine-binding proteins were shown to play no part in penetration of the hormone into the nucleus. The tri-iodothyronine level in the nuclei was directly dependent on the concentration of receptor proteins in them and the degree of occupancy of the acceptor sites in the receptors themselves. More... »

PAGES

17-19

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00802794

DOI

http://dx.doi.org/10.1007/bf00802794

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034568406


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