Recognition signals for mouse pre-rRNA processing View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-05

AUTHORS

J. -P. Bachellerie, B. Michot, F. Raynal

ABSTRACT

In order to identify signals for rRNA processing in eukaryotes, mouse pre-rRNA sequence features around four cleavage sites have been analyzed. No consensus sequence can be recognized when the four boundary regions are examined. Unlike mature rRNA termini, distal sequences of precursor-specific domains cannot participate in stable duplex with adjacent regions. The extensive divergence of precursor-specific sequences during evolution also applies to nucleotides adjacent to cleavage sites, with a significant exception for a conserved segment immediately downstream 5.8S rRNA. A specific role is proposed for U3 nucleolar RNA in the conversion of 32S pre-rRNA into mature 28S rRNA, through base-pairing with precursor-specific sequences at the boundaries of excised domains. More... »

PAGES

79-86

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00777477

DOI

http://dx.doi.org/10.1007/bf00777477

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019001420

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6193412


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