Enhanced productivity of Protein C by recombinant human cells in automated fed-batch cultures View Full Text


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Article Info

DATE

1995-01

AUTHORS

Yun-Seung Kyung, Wei-Shou Hu

ABSTRACT

Recombinant human kidney cells, 293, were cultivated in serum-free fed-batch cultures for the production of Protein C. By coupling the feeding of concentrated medium to pH control based on established stoichiometric relations, the titer of Protein C increased by more than ten fold as compared to batch culture, even though the total cell concentration increased only by less than two fold. Such a fed-batch culture is a simple system for enhancing the productivity of mammalian cells in culture. More... »

PAGES

109-115

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00749398

DOI

http://dx.doi.org/10.1007/bf00749398

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025225197

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22358466


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