Anxiolytic effects of buspirone and gepirone in the fear-potentiated startle paradigm View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-03

AUTHORS

J. H. Kehne, J. V. Cassella, M. Davis

ABSTRACT

Fear potentiation of the acoustic startle reflex was produced by eliciting startle responses in the presence of a light that had been previously paired with a shock. Buspirone (0.6-5.0 mg/kg) and gepirone (1.25-10.0 mg/kg), but not their common metabolite, 1-PP (0.5-40 mg/kg), produced a dose-dependent reduction of fear-potentiated startle. These doses of buspirone and gepirone slightly increased baseline startle levels. Reduction of fear-potentiated startle appears to involve supraspinal sites of action, since intraventricular but not intrathecal administration of buspirone (200 micrograms) reduced fear-enhanced startle. Both buspirone and gepirone were highly efficacious in this model compared to other animal tests that are used to study anxiolytic compounds. More... »

PAGES

8-13

Journal

TITLE

Psychopharmacology

ISSUE

1

VOLUME

94

Author Affiliations

Related Patents

  • 1,2,4-Triazolo[4,3-A]Pyridine Derivatives And Their Use As Positive Allosteric Modulators Of Mglur2 Receptors
  • Imidazo[1,2-A]Pyridine Derivatives And Their Use As Positive Allosteric Modulators Of Mglur2 Receptors
  • 1′,3′-Disubstituted-4-Phenyl-3,4,5,6-Tetrahydro-2h,1′H-[1,4′]Bipyridinyl-2′-Ones
  • 1,2,4-Triazolo[4,3-A]Pyridine Compounds And Their Use As Positive Allosteric Modulators Of Mglur2 Receptors
  • 1,2,4-Triazolo [4,3-A] Pyridine Derivatives And Their Use For The Treatment Of Prevention Of Neurological And Psychiatric Disorders
  • 3-Cyano-4-(4-Tetrahydropyran-Phenyl)-Pyridin-2-One Derivatives
  • 3-Azabicyclo[3.1.0]Hexyl Derivatives As Modulators Of Metabotropic Glutamate Receptors
  • 1′,3′-Disubstituted-4-Phenyl-3,4,5,6-Tetrahydro-2h,1′H-[1,4′] Bipyridinyl-2′-Ones
  • 1,4-Disubstituted 3-Cyano-Pyridone Derivatives And Their Use As Positive Allosteric Modulators Of Mglur2-Receptors
  • 1,2,4-Triazolo[4,3-A] Pyridine Derivatives And Their Use As Positive Allosteric Modulators Of Mglur2 Receptors
  • 1, 4-Disubstituted 3-Cyano-Pyridone Derivatives And Their Use As Positive Allosteric Modulators Of Mglur2-Receptors
  • 1,2,4-Triazolo [4,3-A] Pyridine Derivatives And Their Use For The Treatment Of Prevention Of Neurological And Psychiatric Disorders
  • 1,3-Disubstituted-4-Phenyl-1h-Pyridin-2-Ones
  • Indole And Benzomorpholine Derivatives As Modulators Of Metabotropic Glutamate Receptors
  • 1,2,4-Triazolo[4,3-A]Pyridine Derivatives And Their Use As Positive Allosteric Modulators Of Mglur2 Receptors
  • 1,2,4-Triazolo [4,3-A] Pyridine Derivatives And Their Use For The Treatment Of Neurological And Psychiatric Disorders
  • 1,2,4-Triazolo [4,3-A] Pyridine Derivatives And Their Use For The Treatment Of Prevention Of Neurological And Psychiatric Disorders
  • 1, 4-Disubstituted 3-Cyano-Pyridone Derivatives And Their Use As Positive Allosteric Modulators Of Mglur2-Receptors
  • 1,3-Disubstituted 4-(Aryl-X-Phenyl)-1h-Pyridin-2-Ones
  • 7-Aryl-1,2,4-Triazolo[4,3-A]Pyridine Derivatives And Their Use As Positive Allosteric Modulators Of Mglur2 Receptors
  • 7-Aryl-1,2,4-Triazolo[4,3-A]Pyridine Derivatives And Their Use As Positive Allosteric Modulators Of Mglur2 Receptors
  • 1,2,4-Triazolo[4,3-A]Pyridine Derivatives And Their Use As Positive Allosteric Modulators Of Mglur2 Receptors
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00735872

    DOI

    http://dx.doi.org/10.1007/bf00735872

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1003699268

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2894703


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anti-Anxiety Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Buspirone", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dose-Response Relationship, Drug", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fear", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Injections, Intraventricular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Injections, Spinal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pyrimidines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rats", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rats, Inbred Strains", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reflex, Startle", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Yale University", 
              "id": "https://www.grid.ac/institutes/grid.47100.32", 
              "name": [
                "Ribicoff Research Facilities of the Connecticut Mental Health Center and the Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 06508, New Haven, CT, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kehne", 
            "givenName": "J. H.", 
            "id": "sg:person.012471651024.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012471651024.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Yale University", 
              "id": "https://www.grid.ac/institutes/grid.47100.32", 
              "name": [
                "Ribicoff Research Facilities of the Connecticut Mental Health Center and the Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 06508, New Haven, CT, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cassella", 
            "givenName": "J. V.", 
            "id": "sg:person.010740667404.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010740667404.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Yale University", 
              "id": "https://www.grid.ac/institutes/grid.47100.32", 
              "name": [
                "Ribicoff Research Facilities of the Connecticut Mental Health Center and the Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 06508, New Haven, CT, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Davis", 
            "givenName": "M.", 
            "id": "sg:person.015440304647.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015440304647.07"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/0014-2999(86)90343-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000185366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(86)90343-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000185366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0091-3057(86)90552-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002539653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0091-3057(86)90552-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002539653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0028-3908(83)90118-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006143983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0028-3908(83)90118-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006143983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0031-9384(86)90032-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007619262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0031-9384(86)90032-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007619262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0091-3057(86)90577-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008067852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0091-3057(86)90577-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008067852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0091-3057(86)90585-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010404194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0091-3057(86)90585-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010404194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(81)90121-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010841970"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(81)90121-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010841970"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000118163", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015428254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(79)90063-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017781135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(79)90063-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017781135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-6147(86)90318-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019026339"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1037/0735-7044.100.1.11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021587937"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(83)90404-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023987103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(83)90404-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023987103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ddr.430040110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025380461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00426027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027237697", 
              "https://doi.org/10.1007/bf00426027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00426027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027237697", 
              "https://doi.org/10.1007/bf00426027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00178505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027481045", 
              "https://doi.org/10.1007/bf00178505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00178505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027481045", 
              "https://doi.org/10.1007/bf00178505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-3223(85)90194-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027741809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-3223(85)90194-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027741809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(82)90265-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029778636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(82)90265-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029778636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(81)90499-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030673714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(81)90499-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030673714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00435302", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034574289", 
              "https://doi.org/10.1007/bf00435302"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00435302", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034574289", 
              "https://doi.org/10.1007/bf00435302"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0031-9384(84)90148-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035653845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0031-9384(84)90148-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035653845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00175204", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036396133", 
              "https://doi.org/10.1007/bf00175204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00175204", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036396133", 
              "https://doi.org/10.1007/bf00175204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000284075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036561389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01248997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038562312", 
              "https://doi.org/10.1007/bf01248997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0002-9343(86)90331-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040025487"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(83)90548-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045467215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(83)90548-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045467215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00403634", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047015670", 
              "https://doi.org/10.1007/bf00403634"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00403634", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047015670", 
              "https://doi.org/10.1007/bf00403634"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00735873", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049829748", 
              "https://doi.org/10.1007/bf00735873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00735873", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049829748", 
              "https://doi.org/10.1007/bf00735873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.06-11-03250.1986", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079511146"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079513042", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081581563", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081581566", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.02-06-00791.1982", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082142694"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1988-03", 
        "datePublishedReg": "1988-03-01", 
        "description": "Fear potentiation of the acoustic startle reflex was produced by eliciting startle responses in the presence of a light that had been previously paired with a shock. Buspirone (0.6-5.0 mg/kg) and gepirone (1.25-10.0 mg/kg), but not their common metabolite, 1-PP (0.5-40 mg/kg), produced a dose-dependent reduction of fear-potentiated startle. These doses of buspirone and gepirone slightly increased baseline startle levels. Reduction of fear-potentiated startle appears to involve supraspinal sites of action, since intraventricular but not intrathecal administration of buspirone (200 micrograms) reduced fear-enhanced startle. Both buspirone and gepirone were highly efficacious in this model compared to other animal tests that are used to study anxiolytic compounds.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/bf00735872", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2437152", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2554742", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2406301", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1085440", 
            "issn": [
              "0033-3158", 
              "1432-2072"
            ], 
            "name": "Psychopharmacology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "94"
          }
        ], 
        "name": "Anxiolytic effects of buspirone and gepirone in the fear-potentiated startle paradigm", 
        "pagination": "8-13", 
        "productId": [
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/bf00735872"
            ]
          }, 
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "119f1e862f57d726509125abf5df99c5811406cd8c294daf75c345ac4d98dcde"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1003699268"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "7608025"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "2894703"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/bf00735872", 
          "https://app.dimensions.ai/details/publication/pub.1003699268"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-15T09:03", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000375_0000000375/records_91462_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007/BF00735872"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00735872'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00735872'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00735872'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00735872'


     

    This table displays all metadata directly associated to this object as RDF triples.

    237 TRIPLES      21 PREDICATES      73 URIs      33 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/bf00735872 schema:about N1c3f6c4e83594f389a511d795b9c4fc6
    2 N3943bdc8e89b422a8725269597d5a5b4
    3 N7a381ebe18d94b87a7c609979fb7f372
    4 N90cc858046c143cc9a2f6d14a545085e
    5 Na02ae740e09e475785350da351994970
    6 Na6a5cbe94fd44e8287e05fab84017f5e
    7 Nad55a1a18a2b4bc0857ded04ab1bee6b
    8 Nbc74650454a3462da468f37ff450ce06
    9 Nd1079d13fb2641038eeb789d0e305f0d
    10 Nec0911d0c895403f9e433d90b6301527
    11 Nf02f3ec8e52e4a5982b7d18b0804cfae
    12 Nfd4266981d0e40d78e3c822dd3c5e09b
    13 anzsrc-for:11
    14 anzsrc-for:1109
    15 schema:author N2c45de34656c4fe5a131d2cf427b2d68
    16 schema:citation sg:pub.10.1007/bf00175204
    17 sg:pub.10.1007/bf00178505
    18 sg:pub.10.1007/bf00403634
    19 sg:pub.10.1007/bf00426027
    20 sg:pub.10.1007/bf00435302
    21 sg:pub.10.1007/bf00735873
    22 sg:pub.10.1007/bf01248997
    23 https://app.dimensions.ai/details/publication/pub.1079513042
    24 https://app.dimensions.ai/details/publication/pub.1081581563
    25 https://app.dimensions.ai/details/publication/pub.1081581566
    26 https://doi.org/10.1002/ddr.430040110
    27 https://doi.org/10.1016/0002-9343(86)90331-1
    28 https://doi.org/10.1016/0006-3223(85)90194-5
    29 https://doi.org/10.1016/0006-8993(81)90121-9
    30 https://doi.org/10.1016/0006-8993(83)90548-6
    31 https://doi.org/10.1016/0014-2999(79)90063-3
    32 https://doi.org/10.1016/0014-2999(81)90499-4
    33 https://doi.org/10.1016/0014-2999(82)90265-5
    34 https://doi.org/10.1016/0014-2999(83)90404-1
    35 https://doi.org/10.1016/0014-2999(86)90343-2
    36 https://doi.org/10.1016/0028-3908(83)90118-1
    37 https://doi.org/10.1016/0031-9384(84)90148-3
    38 https://doi.org/10.1016/0031-9384(86)90032-6
    39 https://doi.org/10.1016/0091-3057(86)90552-6
    40 https://doi.org/10.1016/0091-3057(86)90577-0
    41 https://doi.org/10.1016/0091-3057(86)90585-x
    42 https://doi.org/10.1016/0165-6147(86)90318-4
    43 https://doi.org/10.1037/0735-7044.100.1.11
    44 https://doi.org/10.1159/000118163
    45 https://doi.org/10.1159/000284075
    46 https://doi.org/10.1523/jneurosci.02-06-00791.1982
    47 https://doi.org/10.1523/jneurosci.06-11-03250.1986
    48 schema:datePublished 1988-03
    49 schema:datePublishedReg 1988-03-01
    50 schema:description Fear potentiation of the acoustic startle reflex was produced by eliciting startle responses in the presence of a light that had been previously paired with a shock. Buspirone (0.6-5.0 mg/kg) and gepirone (1.25-10.0 mg/kg), but not their common metabolite, 1-PP (0.5-40 mg/kg), produced a dose-dependent reduction of fear-potentiated startle. These doses of buspirone and gepirone slightly increased baseline startle levels. Reduction of fear-potentiated startle appears to involve supraspinal sites of action, since intraventricular but not intrathecal administration of buspirone (200 micrograms) reduced fear-enhanced startle. Both buspirone and gepirone were highly efficacious in this model compared to other animal tests that are used to study anxiolytic compounds.
    51 schema:genre research_article
    52 schema:inLanguage en
    53 schema:isAccessibleForFree false
    54 schema:isPartOf N42ca098deb654e1aadf63b557fcfb225
    55 N80be5f64f22c417da9ad8094a21fce23
    56 sg:journal.1085440
    57 schema:name Anxiolytic effects of buspirone and gepirone in the fear-potentiated startle paradigm
    58 schema:pagination 8-13
    59 schema:productId N39c5f7a99bfa4cf18dae01e682f1b27f
    60 N905e6281222b403a81c45b5c89764571
    61 Nc2fe2415a94341ec904e02ef968d282a
    62 Ncbe7132aedee4050855c3cf961d693d7
    63 Nd7e4c268b45042019d946d0c37684fcf
    64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003699268
    65 https://doi.org/10.1007/bf00735872
    66 schema:sdDatePublished 2019-04-15T09:03
    67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    68 schema:sdPublisher Nacb68a9107f84bfab79a94372b41d64b
    69 schema:url http://link.springer.com/10.1007/BF00735872
    70 sgo:license sg:explorer/license/
    71 sgo:sdDataset articles
    72 rdf:type schema:ScholarlyArticle
    73 N1c3f6c4e83594f389a511d795b9c4fc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    74 schema:name Injections, Spinal
    75 rdf:type schema:DefinedTerm
    76 N2c45de34656c4fe5a131d2cf427b2d68 rdf:first sg:person.012471651024.23
    77 rdf:rest N7cfa8e1153b244ce9b1b87b694088e05
    78 N3943bdc8e89b422a8725269597d5a5b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    79 schema:name Pyrimidines
    80 rdf:type schema:DefinedTerm
    81 N39c5f7a99bfa4cf18dae01e682f1b27f schema:name dimensions_id
    82 schema:value pub.1003699268
    83 rdf:type schema:PropertyValue
    84 N42ca098deb654e1aadf63b557fcfb225 schema:volumeNumber 94
    85 rdf:type schema:PublicationVolume
    86 N7a381ebe18d94b87a7c609979fb7f372 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    87 schema:name Dose-Response Relationship, Drug
    88 rdf:type schema:DefinedTerm
    89 N7cfa8e1153b244ce9b1b87b694088e05 rdf:first sg:person.010740667404.68
    90 rdf:rest Ndeba3c299bff4fa89943f4dc710fe32b
    91 N80be5f64f22c417da9ad8094a21fce23 schema:issueNumber 1
    92 rdf:type schema:PublicationIssue
    93 N905e6281222b403a81c45b5c89764571 schema:name readcube_id
    94 schema:value 119f1e862f57d726509125abf5df99c5811406cd8c294daf75c345ac4d98dcde
    95 rdf:type schema:PropertyValue
    96 N90cc858046c143cc9a2f6d14a545085e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Rats, Inbred Strains
    98 rdf:type schema:DefinedTerm
    99 Na02ae740e09e475785350da351994970 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Fear
    101 rdf:type schema:DefinedTerm
    102 Na6a5cbe94fd44e8287e05fab84017f5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Animals
    104 rdf:type schema:DefinedTerm
    105 Nacb68a9107f84bfab79a94372b41d64b schema:name Springer Nature - SN SciGraph project
    106 rdf:type schema:Organization
    107 Nad55a1a18a2b4bc0857ded04ab1bee6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Anti-Anxiety Agents
    109 rdf:type schema:DefinedTerm
    110 Nbc74650454a3462da468f37ff450ce06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Male
    112 rdf:type schema:DefinedTerm
    113 Nc2fe2415a94341ec904e02ef968d282a schema:name nlm_unique_id
    114 schema:value 7608025
    115 rdf:type schema:PropertyValue
    116 Ncbe7132aedee4050855c3cf961d693d7 schema:name pubmed_id
    117 schema:value 2894703
    118 rdf:type schema:PropertyValue
    119 Nd1079d13fb2641038eeb789d0e305f0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Rats
    121 rdf:type schema:DefinedTerm
    122 Nd7e4c268b45042019d946d0c37684fcf schema:name doi
    123 schema:value 10.1007/bf00735872
    124 rdf:type schema:PropertyValue
    125 Ndeba3c299bff4fa89943f4dc710fe32b rdf:first sg:person.015440304647.07
    126 rdf:rest rdf:nil
    127 Nec0911d0c895403f9e433d90b6301527 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Reflex, Startle
    129 rdf:type schema:DefinedTerm
    130 Nf02f3ec8e52e4a5982b7d18b0804cfae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Buspirone
    132 rdf:type schema:DefinedTerm
    133 Nfd4266981d0e40d78e3c822dd3c5e09b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Injections, Intraventricular
    135 rdf:type schema:DefinedTerm
    136 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    137 schema:name Medical and Health Sciences
    138 rdf:type schema:DefinedTerm
    139 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    140 schema:name Neurosciences
    141 rdf:type schema:DefinedTerm
    142 sg:grant.2406301 http://pending.schema.org/fundedItem sg:pub.10.1007/bf00735872
    143 rdf:type schema:MonetaryGrant
    144 sg:grant.2437152 http://pending.schema.org/fundedItem sg:pub.10.1007/bf00735872
    145 rdf:type schema:MonetaryGrant
    146 sg:grant.2554742 http://pending.schema.org/fundedItem sg:pub.10.1007/bf00735872
    147 rdf:type schema:MonetaryGrant
    148 sg:journal.1085440 schema:issn 0033-3158
    149 1432-2072
    150 schema:name Psychopharmacology
    151 rdf:type schema:Periodical
    152 sg:person.010740667404.68 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
    153 schema:familyName Cassella
    154 schema:givenName J. V.
    155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010740667404.68
    156 rdf:type schema:Person
    157 sg:person.012471651024.23 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
    158 schema:familyName Kehne
    159 schema:givenName J. H.
    160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012471651024.23
    161 rdf:type schema:Person
    162 sg:person.015440304647.07 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
    163 schema:familyName Davis
    164 schema:givenName M.
    165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015440304647.07
    166 rdf:type schema:Person
    167 sg:pub.10.1007/bf00175204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036396133
    168 https://doi.org/10.1007/bf00175204
    169 rdf:type schema:CreativeWork
    170 sg:pub.10.1007/bf00178505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027481045
    171 https://doi.org/10.1007/bf00178505
    172 rdf:type schema:CreativeWork
    173 sg:pub.10.1007/bf00403634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047015670
    174 https://doi.org/10.1007/bf00403634
    175 rdf:type schema:CreativeWork
    176 sg:pub.10.1007/bf00426027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027237697
    177 https://doi.org/10.1007/bf00426027
    178 rdf:type schema:CreativeWork
    179 sg:pub.10.1007/bf00435302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034574289
    180 https://doi.org/10.1007/bf00435302
    181 rdf:type schema:CreativeWork
    182 sg:pub.10.1007/bf00735873 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049829748
    183 https://doi.org/10.1007/bf00735873
    184 rdf:type schema:CreativeWork
    185 sg:pub.10.1007/bf01248997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038562312
    186 https://doi.org/10.1007/bf01248997
    187 rdf:type schema:CreativeWork
    188 https://app.dimensions.ai/details/publication/pub.1079513042 schema:CreativeWork
    189 https://app.dimensions.ai/details/publication/pub.1081581563 schema:CreativeWork
    190 https://app.dimensions.ai/details/publication/pub.1081581566 schema:CreativeWork
    191 https://doi.org/10.1002/ddr.430040110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025380461
    192 rdf:type schema:CreativeWork
    193 https://doi.org/10.1016/0002-9343(86)90331-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040025487
    194 rdf:type schema:CreativeWork
    195 https://doi.org/10.1016/0006-3223(85)90194-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027741809
    196 rdf:type schema:CreativeWork
    197 https://doi.org/10.1016/0006-8993(81)90121-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010841970
    198 rdf:type schema:CreativeWork
    199 https://doi.org/10.1016/0006-8993(83)90548-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045467215
    200 rdf:type schema:CreativeWork
    201 https://doi.org/10.1016/0014-2999(79)90063-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017781135
    202 rdf:type schema:CreativeWork
    203 https://doi.org/10.1016/0014-2999(81)90499-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030673714
    204 rdf:type schema:CreativeWork
    205 https://doi.org/10.1016/0014-2999(82)90265-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029778636
    206 rdf:type schema:CreativeWork
    207 https://doi.org/10.1016/0014-2999(83)90404-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023987103
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1016/0014-2999(86)90343-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000185366
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1016/0028-3908(83)90118-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006143983
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1016/0031-9384(84)90148-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035653845
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1016/0031-9384(86)90032-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007619262
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1016/0091-3057(86)90552-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002539653
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1016/0091-3057(86)90577-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008067852
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1016/0091-3057(86)90585-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010404194
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1016/0165-6147(86)90318-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019026339
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1037/0735-7044.100.1.11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021587937
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1159/000118163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015428254
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1159/000284075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036561389
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1523/jneurosci.02-06-00791.1982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082142694
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1523/jneurosci.06-11-03250.1986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079511146
    234 rdf:type schema:CreativeWork
    235 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
    236 schema:name Ribicoff Research Facilities of the Connecticut Mental Health Center and the Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 06508, New Haven, CT, USA
    237 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...