Determination of structural elements of the L2/HNK-1 carbohydrate epitope required for its function View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-08

AUTHORS

B. Schmitz, M. Schachner, Y. Ito, T. Nakano, T. Ogawa

ABSTRACT

The L2/HNK-1 carbohydrate epitope has been shown to carry an unusual 3'-sulfoglucuronic acid linked O-glycosidically through a neolactosyl-type backbone to a ceramide residue. Using monoclonal antibodies, the same or a closely related epitope has also been detected N-glycosidically linked to glycoproteins, amongst them several neural cell adhesion molecules. We used synthetic glycolipids carrying sulfated or non-sulfated glucuronic acid attached to ceramide through glycans of different length to show that not only the sulfated glucuronic acid but also the neolactosyl-type backbone is essential for the recognition of the L2/HNK-1 carbohydrate by a monoclonal antibody, its binding to laminin and its role in neural cell migration and outgrowth of processes from neurons and astrocytes. More... »

PAGES

345-352

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00731208

DOI

http://dx.doi.org/10.1007/bf00731208

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022246719

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7533016


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