Ontology type: schema:ScholarlyArticle
1989-01
AUTHORSTakeshi Komatsu, Masashi Yamamoto, Kaoru Shimokata, Hiroshi Nagura
ABSTRACTMajor histocompatibility complex (MHC) class II antigens are essential in the presentation of antigens to T lymphocytes, and cells expressing MHC class II antigens are known to play a role as antigen presenting cells (APC). We investigated the distribution of MHC class II antigens and the reactivity of monoclonal antibodies OKM1 and OKM5 in normal and fibrotic lungs immunohistochemically. The results showed that alveolar capillary endothelial cells (ACEnd) expressed MHC class II antigens and were reactive with OKM5 in both normal lungs and the non-thickened parts of alveolar septa of pulmonary fibrosis. However, ACEnd did not express MHC class II antigens and were not reactive with OKM5 in thickened alveolar septa of pulmonary fibrosis. Type II alveolar epithelial cells (AEp) proliferating and replacing type I AEp in pulmonary fibrosis expressed MHC class II antigens strongly. Alveolar macrophages expressed MHC class II antigens strongly and reacted with OKM1 in pulmonary fibrosis, especially in alveolar spaces. These findings suggest that the phenotypic changes of ACEnd may be involved in the process of pulmonary fibrosis, and type II AEp and alveolar macrophages in the parts of thickened alveolar septa may play a role as APC. More... »
PAGES79-90
http://scigraph.springernature.com/pub.10.1007/bf00718607
DOIhttp://dx.doi.org/10.1007/bf00718607
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1016157623
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/2499981
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antibodies, Monoclonal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Capillaries",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Endothelium, Vascular",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Epithelium",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Histocompatibility Antigens Class II",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunohistochemistry",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Macrophages",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Microscopy, Electron",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Phenotype",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Pulmonary Alveoli",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Pulmonary Fibrosis",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "First Department of Medicine, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466, Nagoya, Japan",
"id": "http://www.grid.ac/institutes/grid.27476.30",
"name": [
"First Department of Medicine, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466, Nagoya, Japan"
],
"type": "Organization"
},
"familyName": "Komatsu",
"givenName": "Takeshi",
"id": "sg:person.01246275443.58",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246275443.58"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "First Department of Medicine, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466, Nagoya, Japan",
"id": "http://www.grid.ac/institutes/grid.27476.30",
"name": [
"First Department of Medicine, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466, Nagoya, Japan"
],
"type": "Organization"
},
"familyName": "Yamamoto",
"givenName": "Masashi",
"id": "sg:person.07562544504.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07562544504.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "First Department of Medicine, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466, Nagoya, Japan",
"id": "http://www.grid.ac/institutes/grid.27476.30",
"name": [
"First Department of Medicine, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466, Nagoya, Japan"
],
"type": "Organization"
},
"familyName": "Shimokata",
"givenName": "Kaoru",
"id": "sg:person.01222406666.04",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222406666.04"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Laboratory of Germfree Life Research, Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan",
"id": "http://www.grid.ac/institutes/grid.27476.30",
"name": [
"Laboratory of Germfree Life Research, Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan"
],
"type": "Organization"
},
"familyName": "Nagura",
"givenName": "Hiroshi",
"id": "sg:person.0723362470.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723362470.15"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/bf00429611",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030778569",
"https://doi.org/10.1007/bf00429611"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/305726a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000907348",
"https://doi.org/10.1038/305726a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-4684-5344-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046134753",
"https://doi.org/10.1007/978-1-4684-5344-7"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-4613-2825-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048914408",
"https://doi.org/10.1007/978-1-4613-2825-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00705413",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026944354",
"https://doi.org/10.1007/bf00705413"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00750257",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028993067",
"https://doi.org/10.1007/bf00750257"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/313061a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037121267",
"https://doi.org/10.1038/313061a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/312639a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022396706",
"https://doi.org/10.1038/312639a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00917334",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011555494",
"https://doi.org/10.1007/bf00917334"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00705300",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052211038",
"https://doi.org/10.1007/bf00705300"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00750582",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053289680",
"https://doi.org/10.1007/bf00750582"
],
"type": "CreativeWork"
}
],
"datePublished": "1989-01",
"datePublishedReg": "1989-01-01",
"description": "Major histocompatibility complex (MHC) class II antigens are essential in the presentation of antigens to T lymphocytes, and cells expressing MHC class II antigens are known to play a role as antigen presenting cells (APC). We investigated the distribution of MHC class II antigens and the reactivity of monoclonal antibodies OKM1 and OKM5 in normal and fibrotic lungs immunohistochemically. The results showed that alveolar capillary endothelial cells (ACEnd) expressed MHC class II antigens and were reactive with OKM5 in both normal lungs and the non-thickened parts of alveolar septa of pulmonary fibrosis. However, ACEnd did not express MHC class II antigens and were not reactive with OKM5 in thickened alveolar septa of pulmonary fibrosis. Type II alveolar epithelial cells (AEp) proliferating and replacing type I AEp in pulmonary fibrosis expressed MHC class II antigens strongly. Alveolar macrophages expressed MHC class II antigens strongly and reacted with OKM1 in pulmonary fibrosis, especially in alveolar spaces. These findings suggest that the phenotypic changes of ACEnd may be involved in the process of pulmonary fibrosis, and type II AEp and alveolar macrophages in the parts of thickened alveolar septa may play a role as APC.",
"genre": "article",
"id": "sg:pub.10.1007/bf00718607",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1009231",
"issn": [
"0174-7398"
],
"name": "Virchows Archiv A Pathological Anatomy and Histopathology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "415"
}
],
"keywords": [
"MHC class II antigens",
"class II antigens",
"antigen presenting cells",
"alveolar epithelial cells",
"alveolar capillary endothelial cells",
"type II alveolar epithelial cells",
"pulmonary fibrosis",
"II antigens",
"capillary endothelial cells",
"alveolar septa",
"alveolar macrophages",
"major histocompatibility complex class II antigens",
"endothelial cells",
"epithelial cells",
"MHC class II",
"presentation of antigens",
"monoclonal antibody OKM1",
"presenting cells",
"fibrotic lungs",
"T lymphocytes",
"normal lung",
"alveolar space",
"fibrosis",
"class II",
"antigen",
"OKM5",
"macrophages",
"OKM1",
"septum",
"lung",
"type I",
"cells",
"phenotypic changes",
"phenotypic characterization",
"patients",
"ACEND",
"lymphocytes",
"special reference",
"presentation",
"role",
"findings",
"changes",
"reactivity",
"part",
"results",
"reference",
"characterization",
"distribution",
"process",
"space"
],
"name": "Phenotypic characterization of alveolar capillary endothelial cells, alveolar epithelial cells and alveolar macrophages in patients with pulmonary fibrosis, with special reference to MHC class II antigens",
"pagination": "79-90",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1016157623"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/bf00718607"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"2499981"
]
}
],
"sameAs": [
"https://doi.org/10.1007/bf00718607",
"https://app.dimensions.ai/details/publication/pub.1016157623"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T16:51",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_203.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/bf00718607"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00718607'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00718607'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00718607'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00718607'
This table displays all metadata directly associated to this object as RDF triples.
225 TRIPLES
21 PREDICATES
99 URIs
80 LITERALS
19 BLANK NODES