Hepatic vascular endothelial cells heterogenously express surface antigens associated with monocytes, macrophages and T lymphocytes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-07

AUTHORS

H. Nagura, T. Koshikawa, Y. Fukuda, J. Asai

ABSTRACT

During studies of the antigenic and functional properties of hepatic sinusoidal lining cells in situ, we found that only the sinusoidal endothelial cells share antigens with a peripheral blood macrophage subset capable of presenting soluble antigens and triggering autologous mixed lymphocyte reactions. They were HLA-DR+, OKM1−, OKM5+. Vascular endothelial cells in the portal areas and central veins were HLA-DR+, OKM1− and OKM5−. The sinusoidal endothelial cells also expressed an antigen found on helper/inducer (OKT4 and Leu3 a) T lymphocytes. Thus, the present study suggests that endothelial cells in different anatomic compartments in the liver heterogenously express surface antigens associated with monocytes, macrophages and T lymphocytes and possess distinct immunological functions. More... »

PAGES

407-416

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00705413

DOI

http://dx.doi.org/10.1007/bf00705413

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026944354

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3090771


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