Distribution of hexadecylphosphocholine and octadecyl-methyl-glycero-3-phosphocholine in rat tissues during steady-state treatment View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-01

AUTHORS

Norbert Marschner, Jochem Kötting, Hansjörg Eibl, Clemens Unger

ABSTRACT

The distribution of the alkylphosphocholine hexadecylphosphocholine (He-PC) and the (alkyl)lysophospholipid 1-0-octadecyl-2-0-methyl-rac-glycero-3-phosphocholine (ET18-OCH3) was analyzed in rats. The compounds were given orally at a daily dose of 75 mumol/kg body weight. After 6, 11, and 18 days, three rats in each treatment group were killed and the drug concentration in various tissues and fluids was determined. With the exception of the kidney (He-PC) and brain (He-PC and ET18-OCH3), steady-state levels of the drugs could be achieved in all organs investigated and in serum. Maximal concentrations of He-PC were found in the kidney, adrenal glands, and spleen, whereas the highest concentrations of ET18-OCH3 were detected in the adrenal glands, spleen, and small intestine. The concentrations of He-PC exceeded those of ET18-OCH3 in most tissues by a factor of about 2-25. Since samples of urine and feces did not contain detectable amounts of the compounds, the absorption of both lipid analogues was assumed to be complete. The total amount of He-PC recovered after 6, 11, and 18 days was 15%, 12%, and 6%, respectively, and that of ET18-OCH3 was 1.3%, 0.8%, and 0.3%, respectively. This indicates that the bioavailability of He-PC and ET18-OCH3 is not controlled by differences in the uptake of the two drugs, but by differences in their metabolism. The results could explain the differing efficacy of these two compounds in their antitumor action in animal models. More... »

PAGES

18-22

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00695989

DOI

http://dx.doi.org/10.1007/bf00695989

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046635745

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1458555


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Oral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatography, Thin Layer", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Densitometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Administration Schedule", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phospholipid Ethers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylcholine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Wistar", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproducibility of Results", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sensitivity and Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Distribution", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsmedizin G\u00f6ttingen", 
          "id": "https://www.grid.ac/institutes/grid.411984.1", 
          "name": [
            "Division of Hematology/Oncology, Department of Internal Medicine, University Hospital, D-3400, G\u00f6ttingen, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marschner", 
        "givenName": "Norbert", 
        "id": "sg:person.01112672214.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112672214.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Biophysical Chemistry", 
          "id": "https://www.grid.ac/institutes/grid.418140.8", 
          "name": [
            "Max-Planck-Institute for Biophysical Chemistry, D-3400, G\u00f6ttingen, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "K\u00f6tting", 
        "givenName": "Jochem", 
        "id": "sg:person.01101172752.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101172752.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Biophysical Chemistry", 
          "id": "https://www.grid.ac/institutes/grid.418140.8", 
          "name": [
            "Max-Planck-Institute for Biophysical Chemistry, D-3400, G\u00f6ttingen, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eibl", 
        "givenName": "Hansj\u00f6rg", 
        "id": "sg:person.01105334622.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105334622.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsmedizin G\u00f6ttingen", 
          "id": "https://www.grid.ac/institutes/grid.411984.1", 
          "name": [
            "Division of Hematology/Oncology, Department of Internal Medicine, University Hospital, D-3400, G\u00f6ttingen, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Unger", 
        "givenName": "Clemens", 
        "id": "sg:person.0704572215.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704572215.43"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/jhrc.1240040816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003025392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jhrc.1240040816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003025392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01612994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019613494", 
          "https://doi.org/10.1007/bf01612994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01612994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019613494", 
          "https://doi.org/10.1007/bf01612994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02535542", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022618743", 
          "https://doi.org/10.1007/bf02535542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02535558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023947179", 
          "https://doi.org/10.1007/bf02535558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01612758", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027286828", 
          "https://doi.org/10.1007/bf01612758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01612758", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027286828", 
          "https://doi.org/10.1007/bf01612758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02535562", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028686569", 
          "https://doi.org/10.1007/bf02535562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02535556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029511128", 
          "https://doi.org/10.1007/bf02535556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-3084(86)90124-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032163103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-3084(86)90124-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032163103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0277-5379(88)90336-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033699947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000216779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035336269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02535544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039344194", 
          "https://doi.org/10.1007/bf02535544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000225803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042146781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000420825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076479598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000420837", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076479602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077461485", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078398866", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078733586", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079703784", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/75.3.423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079999128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080729177", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/72.1.53", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081838333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081992360", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082285494", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1992-01", 
    "datePublishedReg": "1992-01-01", 
    "description": "The distribution of the alkylphosphocholine hexadecylphosphocholine (He-PC) and the (alkyl)lysophospholipid 1-0-octadecyl-2-0-methyl-rac-glycero-3-phosphocholine (ET18-OCH3) was analyzed in rats. The compounds were given orally at a daily dose of 75 mumol/kg body weight. After 6, 11, and 18 days, three rats in each treatment group were killed and the drug concentration in various tissues and fluids was determined. With the exception of the kidney (He-PC) and brain (He-PC and ET18-OCH3), steady-state levels of the drugs could be achieved in all organs investigated and in serum. Maximal concentrations of He-PC were found in the kidney, adrenal glands, and spleen, whereas the highest concentrations of ET18-OCH3 were detected in the adrenal glands, spleen, and small intestine. The concentrations of He-PC exceeded those of ET18-OCH3 in most tissues by a factor of about 2-25. Since samples of urine and feces did not contain detectable amounts of the compounds, the absorption of both lipid analogues was assumed to be complete. The total amount of He-PC recovered after 6, 11, and 18 days was 15%, 12%, and 6%, respectively, and that of ET18-OCH3 was 1.3%, 0.8%, and 0.3%, respectively. This indicates that the bioavailability of He-PC and ET18-OCH3 is not controlled by differences in the uptake of the two drugs, but by differences in their metabolism. The results could explain the differing efficacy of these two compounds in their antitumor action in animal models.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00695989", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1088364", 
        "issn": [
          "0344-5704", 
          "1432-0843"
        ], 
        "name": "Cancer Chemotherapy and Pharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "31"
      }
    ], 
    "name": "Distribution of hexadecylphosphocholine and octadecyl-methyl-glycero-3-phosphocholine in rat tissues during steady-state treatment", 
    "pagination": "18-22", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "de27347f32241ed018d17bcef6c56498af0e630d19542ad77a27d5528065c004"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "1458555"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7806519"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00695989"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046635745"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00695989", 
      "https://app.dimensions.ai/details/publication/pub.1046635745"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000372_0000000372/records_117106_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF00695989"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00695989'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00695989'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00695989'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00695989'


 

This table displays all metadata directly associated to this object as RDF triples.

218 TRIPLES      21 PREDICATES      66 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00695989 schema:about N0c39e74d152049f595f1200c67291651
2 N296616d6cda846b9ace042c9b3844f22
3 N371230f06c3046538ee8bdb76ef86084
4 N424ed5317bbe45b5a244339e1c7085e8
5 N7dceed7ee3e54be1b96b6fde93f42ed3
6 N8a1c75a4669340d384a0a46f4848bcda
7 N9118c2f76d48402cadd6f89acf809f8c
8 N94d0ececc9194a49b214c7b207fb2b4e
9 N9612a78f96cb4d65922f1f7ee13f1216
10 Na3ddb9e26c354a58bcfd21afd59cad2a
11 Nb2a68de8454849b6af41a811db38f271
12 Nb849efe7d63344e6b581c998d8d6ca52
13 Nd6ad099f324b416aa2403d2fe393c4ea
14 Ne2a354dd31b3460fa033f67294ff73ab
15 anzsrc-for:11
16 anzsrc-for:1115
17 schema:author Nbc805491ecb04326b0db8157b9d0eac7
18 schema:citation sg:pub.10.1007/bf01612758
19 sg:pub.10.1007/bf01612994
20 sg:pub.10.1007/bf02535542
21 sg:pub.10.1007/bf02535544
22 sg:pub.10.1007/bf02535556
23 sg:pub.10.1007/bf02535558
24 sg:pub.10.1007/bf02535562
25 https://app.dimensions.ai/details/publication/pub.1077461485
26 https://app.dimensions.ai/details/publication/pub.1078398866
27 https://app.dimensions.ai/details/publication/pub.1078733586
28 https://app.dimensions.ai/details/publication/pub.1079703784
29 https://app.dimensions.ai/details/publication/pub.1080729177
30 https://app.dimensions.ai/details/publication/pub.1081992360
31 https://app.dimensions.ai/details/publication/pub.1082285494
32 https://doi.org/10.1002/jhrc.1240040816
33 https://doi.org/10.1016/0009-3084(86)90124-6
34 https://doi.org/10.1016/0277-5379(88)90336-7
35 https://doi.org/10.1093/jnci/72.1.53
36 https://doi.org/10.1093/jnci/75.3.423
37 https://doi.org/10.1159/000216779
38 https://doi.org/10.1159/000225803
39 https://doi.org/10.1159/000420825
40 https://doi.org/10.1159/000420837
41 schema:datePublished 1992-01
42 schema:datePublishedReg 1992-01-01
43 schema:description The distribution of the alkylphosphocholine hexadecylphosphocholine (He-PC) and the (alkyl)lysophospholipid 1-0-octadecyl-2-0-methyl-rac-glycero-3-phosphocholine (ET18-OCH3) was analyzed in rats. The compounds were given orally at a daily dose of 75 mumol/kg body weight. After 6, 11, and 18 days, three rats in each treatment group were killed and the drug concentration in various tissues and fluids was determined. With the exception of the kidney (He-PC) and brain (He-PC and ET18-OCH3), steady-state levels of the drugs could be achieved in all organs investigated and in serum. Maximal concentrations of He-PC were found in the kidney, adrenal glands, and spleen, whereas the highest concentrations of ET18-OCH3 were detected in the adrenal glands, spleen, and small intestine. The concentrations of He-PC exceeded those of ET18-OCH3 in most tissues by a factor of about 2-25. Since samples of urine and feces did not contain detectable amounts of the compounds, the absorption of both lipid analogues was assumed to be complete. The total amount of He-PC recovered after 6, 11, and 18 days was 15%, 12%, and 6%, respectively, and that of ET18-OCH3 was 1.3%, 0.8%, and 0.3%, respectively. This indicates that the bioavailability of He-PC and ET18-OCH3 is not controlled by differences in the uptake of the two drugs, but by differences in their metabolism. The results could explain the differing efficacy of these two compounds in their antitumor action in animal models.
44 schema:genre research_article
45 schema:inLanguage en
46 schema:isAccessibleForFree false
47 schema:isPartOf N0e588ad5166a485ab72e6aa69af525c5
48 Na04e0ff034084366a667050f4d65cc26
49 sg:journal.1088364
50 schema:name Distribution of hexadecylphosphocholine and octadecyl-methyl-glycero-3-phosphocholine in rat tissues during steady-state treatment
51 schema:pagination 18-22
52 schema:productId N2cbd1b80a1b7493b8ad505638f0edfd3
53 N373ed212df2c4d889fa112c660ce19c5
54 N66decc0384974017b3968ab0a19e83df
55 N72c24910e6a246a89752882bc663c7d4
56 N7d28cf8b88cd4cf9993765c3c3b6edfd
57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046635745
58 https://doi.org/10.1007/bf00695989
59 schema:sdDatePublished 2019-04-11T14:18
60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
61 schema:sdPublisher Nd4f585445214431984a7df90ea200b3f
62 schema:url http://link.springer.com/10.1007/BF00695989
63 sgo:license sg:explorer/license/
64 sgo:sdDataset articles
65 rdf:type schema:ScholarlyArticle
66 N0c39e74d152049f595f1200c67291651 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Reproducibility of Results
68 rdf:type schema:DefinedTerm
69 N0e588ad5166a485ab72e6aa69af525c5 schema:volumeNumber 31
70 rdf:type schema:PublicationVolume
71 N296616d6cda846b9ace042c9b3844f22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Densitometry
73 rdf:type schema:DefinedTerm
74 N2cbd1b80a1b7493b8ad505638f0edfd3 schema:name pubmed_id
75 schema:value 1458555
76 rdf:type schema:PropertyValue
77 N371230f06c3046538ee8bdb76ef86084 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Chromatography, Thin Layer
79 rdf:type schema:DefinedTerm
80 N373ed212df2c4d889fa112c660ce19c5 schema:name doi
81 schema:value 10.1007/bf00695989
82 rdf:type schema:PropertyValue
83 N42102401c1f4405eadce7ff699348754 rdf:first sg:person.01105334622.36
84 rdf:rest Neba83b34798f4048a7987b768cf3935c
85 N424ed5317bbe45b5a244339e1c7085e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Sensitivity and Specificity
87 rdf:type schema:DefinedTerm
88 N66decc0384974017b3968ab0a19e83df schema:name readcube_id
89 schema:value de27347f32241ed018d17bcef6c56498af0e630d19542ad77a27d5528065c004
90 rdf:type schema:PropertyValue
91 N72c24910e6a246a89752882bc663c7d4 schema:name nlm_unique_id
92 schema:value 7806519
93 rdf:type schema:PropertyValue
94 N7d28cf8b88cd4cf9993765c3c3b6edfd schema:name dimensions_id
95 schema:value pub.1046635745
96 rdf:type schema:PropertyValue
97 N7dceed7ee3e54be1b96b6fde93f42ed3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Administration, Oral
99 rdf:type schema:DefinedTerm
100 N8a1c75a4669340d384a0a46f4848bcda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Rats
102 rdf:type schema:DefinedTerm
103 N9118c2f76d48402cadd6f89acf809f8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Phosphorylcholine
105 rdf:type schema:DefinedTerm
106 N94d0ececc9194a49b214c7b207fb2b4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Female
108 rdf:type schema:DefinedTerm
109 N9612a78f96cb4d65922f1f7ee13f1216 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Drug Administration Schedule
111 rdf:type schema:DefinedTerm
112 Na04e0ff034084366a667050f4d65cc26 schema:issueNumber 1
113 rdf:type schema:PublicationIssue
114 Na3ddb9e26c354a58bcfd21afd59cad2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Animals
116 rdf:type schema:DefinedTerm
117 Nb2a68de8454849b6af41a811db38f271 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Tissue Distribution
119 rdf:type schema:DefinedTerm
120 Nb849efe7d63344e6b581c998d8d6ca52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Phospholipid Ethers
122 rdf:type schema:DefinedTerm
123 Nbc805491ecb04326b0db8157b9d0eac7 rdf:first sg:person.01112672214.22
124 rdf:rest Ne3afcd53476641ac9ccb6d375a8b8b1e
125 Nd4f585445214431984a7df90ea200b3f schema:name Springer Nature - SN SciGraph project
126 rdf:type schema:Organization
127 Nd6ad099f324b416aa2403d2fe393c4ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Antineoplastic Agents
129 rdf:type schema:DefinedTerm
130 Ne2a354dd31b3460fa033f67294ff73ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Rats, Wistar
132 rdf:type schema:DefinedTerm
133 Ne3afcd53476641ac9ccb6d375a8b8b1e rdf:first sg:person.01101172752.56
134 rdf:rest N42102401c1f4405eadce7ff699348754
135 Neba83b34798f4048a7987b768cf3935c rdf:first sg:person.0704572215.43
136 rdf:rest rdf:nil
137 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
138 schema:name Medical and Health Sciences
139 rdf:type schema:DefinedTerm
140 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
141 schema:name Pharmacology and Pharmaceutical Sciences
142 rdf:type schema:DefinedTerm
143 sg:journal.1088364 schema:issn 0344-5704
144 1432-0843
145 schema:name Cancer Chemotherapy and Pharmacology
146 rdf:type schema:Periodical
147 sg:person.01101172752.56 schema:affiliation https://www.grid.ac/institutes/grid.418140.8
148 schema:familyName Kötting
149 schema:givenName Jochem
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101172752.56
151 rdf:type schema:Person
152 sg:person.01105334622.36 schema:affiliation https://www.grid.ac/institutes/grid.418140.8
153 schema:familyName Eibl
154 schema:givenName Hansjörg
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105334622.36
156 rdf:type schema:Person
157 sg:person.01112672214.22 schema:affiliation https://www.grid.ac/institutes/grid.411984.1
158 schema:familyName Marschner
159 schema:givenName Norbert
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112672214.22
161 rdf:type schema:Person
162 sg:person.0704572215.43 schema:affiliation https://www.grid.ac/institutes/grid.411984.1
163 schema:familyName Unger
164 schema:givenName Clemens
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704572215.43
166 rdf:type schema:Person
167 sg:pub.10.1007/bf01612758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027286828
168 https://doi.org/10.1007/bf01612758
169 rdf:type schema:CreativeWork
170 sg:pub.10.1007/bf01612994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019613494
171 https://doi.org/10.1007/bf01612994
172 rdf:type schema:CreativeWork
173 sg:pub.10.1007/bf02535542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022618743
174 https://doi.org/10.1007/bf02535542
175 rdf:type schema:CreativeWork
176 sg:pub.10.1007/bf02535544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039344194
177 https://doi.org/10.1007/bf02535544
178 rdf:type schema:CreativeWork
179 sg:pub.10.1007/bf02535556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029511128
180 https://doi.org/10.1007/bf02535556
181 rdf:type schema:CreativeWork
182 sg:pub.10.1007/bf02535558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023947179
183 https://doi.org/10.1007/bf02535558
184 rdf:type schema:CreativeWork
185 sg:pub.10.1007/bf02535562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028686569
186 https://doi.org/10.1007/bf02535562
187 rdf:type schema:CreativeWork
188 https://app.dimensions.ai/details/publication/pub.1077461485 schema:CreativeWork
189 https://app.dimensions.ai/details/publication/pub.1078398866 schema:CreativeWork
190 https://app.dimensions.ai/details/publication/pub.1078733586 schema:CreativeWork
191 https://app.dimensions.ai/details/publication/pub.1079703784 schema:CreativeWork
192 https://app.dimensions.ai/details/publication/pub.1080729177 schema:CreativeWork
193 https://app.dimensions.ai/details/publication/pub.1081992360 schema:CreativeWork
194 https://app.dimensions.ai/details/publication/pub.1082285494 schema:CreativeWork
195 https://doi.org/10.1002/jhrc.1240040816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003025392
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/0009-3084(86)90124-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032163103
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/0277-5379(88)90336-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033699947
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1093/jnci/72.1.53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081838333
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1093/jnci/75.3.423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079999128
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1159/000216779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035336269
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1159/000225803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042146781
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1159/000420825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076479598
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1159/000420837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076479602
212 rdf:type schema:CreativeWork
213 https://www.grid.ac/institutes/grid.411984.1 schema:alternateName Universitätsmedizin Göttingen
214 schema:name Division of Hematology/Oncology, Department of Internal Medicine, University Hospital, D-3400, Göttingen, Federal Republic of Germany
215 rdf:type schema:Organization
216 https://www.grid.ac/institutes/grid.418140.8 schema:alternateName Max Planck Institute for Biophysical Chemistry
217 schema:name Max-Planck-Institute for Biophysical Chemistry, D-3400, Göttingen, Federal Republic of Germany
218 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...