Immunoglobulins in demyelinating lesions in canine distemper encephalitis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1981-03

AUTHORS

M. Vandevelde, R. Fankhauser, F. Kristensen, B. Kristensen

ABSTRACT

The brains of 14 dogs with canine distemper encephalitis were examined with immunohistologic techniques to search for immunoglobulin in demyelinating lesions. Four types of lesions presumably representing a temporal sequence of lesion development were distinguished. Immunohistologic findings included immunoglobulin bearing lymphoid cells, amorphous Ig containing material, immunoglobulin bound to the tissue and immunoglobulin containing macrophages and astrocytes. The humoral immune response was absent or very minimal in acute lesions and very intense in chronic lesions. It was concluded that early demyelination in canine distemper encephalitis occurs in the absence of a local humoral immune response but that this response may aggravate and accelerate myelin destruction in the later stages of the disease. More... »

PAGES

31-41

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00691330

DOI

http://dx.doi.org/10.1007/bf00691330

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008262329

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7234327


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