Alkylphosphocholines: influence of structural variation on biodistribution at antineoplastically active concentrations View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-03

AUTHORS

Jochem Kötting, Martin R. Berger, Clemens Unger, Hansjörg Eibl

ABSTRACT

Hexadecylphosphocholine (HPC) and octadecylphosphocholine (OPC) show very potent antitumor activity against autochthonous methylnitrosourea-induced mammary carcinomas in rats. The longer-chain and unsaturated homologue erucylphosphocholine (EPC) forms lamellar structures rather than micelles, but nonetheless exhibits antineoplastic activity. Methylnitrosourea was used in the present study to induce autochthonous mammary carcinomas in virgin Sprague-Dawley rats. At 6 and 11 days following oral therapy, the biodistribution of HPC, OPC and EPC was analyzed in the serum, tumor, liver, kidney, lung, small intestine, brain and spleen of rats by high-performance thin-layer chromatography. In contrast to the almost identical tumor response noted, the distribution of the three homologues differed markedly. The serum levels of 50 nmol/ml obtained for OPC and EPC were much lower than the value of 120 nmol/ml measured for HPC. Nevertheless, the quite different serum levels resulted in similar tumor concentrations of about 200 nmol/g for all three of the compounds. Whereas HPC preferably accumulated in the kidney (1 mumol/g), OPC was found at increased concentrations (400 nmol/g) in the spleen, kidney and lung. In spite of the high daily dose of 120 mumol/kg EPC as compared with 51 mumol/kg HPC or OPC, EPC concentrations (100-200 nmol/g) were low in most tissues. High EPC concentrations were found in the small intestine (628 nmol/g). Values of 170 nmol/g were found for HPC and OPC in the brain, whereas the EPC concentration was 120 nmol/g. Obviously, structural modifications in the alkyl chain strongly influence the distribution pattern of alkylphosphocholines in animals. Since EPC yielded the highest tissue-to-serum concentration ratio in tumor tissue (5.1) and the lowest levels in other organs, we conclude that EPC is the most promising candidate for drug development in cancer therapy. More... »

PAGES

105-112

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00686401

DOI

http://dx.doi.org/10.1007/bf00686401

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005712297

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1600590


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatography, High Pressure Liquid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mammary Neoplasms, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methylnitrosourea", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphatidylcholines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylcholine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Inbred Strains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Structure-Activity Relationship", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Distribution", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Biophysical Chemistry", 
          "id": "https://www.grid.ac/institutes/grid.418140.8", 
          "name": [
            "Max-Planck-Institut f\u00fcr biophysikalische Chemie, Am Fassberg, D-3400, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "K\u00f6tting", 
        "givenName": "Jochem", 
        "id": "sg:person.01101172752.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101172752.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Institut f\u00fcr Toxikologie u. Chemotherapie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-6900, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berger", 
        "givenName": "Martin R.", 
        "id": "sg:person.01256203524.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256203524.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsmedizin G\u00f6ttingen", 
          "id": "https://www.grid.ac/institutes/grid.411984.1", 
          "name": [
            "Abt. H\u00e4matologie/Onkologie, Medizinische Universit\u00e4tsklinik, Robert-Koch-Strasse 40, D-3400, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Unger", 
        "givenName": "Clemens", 
        "id": "sg:person.0704572215.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704572215.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Biophysical Chemistry", 
          "id": "https://www.grid.ac/institutes/grid.418140.8", 
          "name": [
            "Max-Planck-Institut f\u00fcr biophysikalische Chemie, Am Fassberg, D-3400, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eibl", 
        "givenName": "Hansj\u00f6rg", 
        "id": "sg:person.01105334622.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105334622.36"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0009-3084(88)90033-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008699912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-3084(88)90033-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008699912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-3084(88)90032-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012055995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-3084(88)90032-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012055995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01612994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019613494", 
          "https://doi.org/10.1007/bf01612994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01612994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019613494", 
          "https://doi.org/10.1007/bf01612994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj1400503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020286223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj1400503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020286223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000216563", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023417782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02535558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023947179", 
          "https://doi.org/10.1007/bf02535558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02535556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029511128", 
          "https://doi.org/10.1007/bf02535556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-3084(88)90031-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032231348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-3084(88)90031-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032231348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0277-5379(88)90336-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033699947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000216779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035336269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/02841868909111249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036404133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0305-7372(90)90053-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036687880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0305-7372(87)90023-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039400953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/lipi.19880900905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040462594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02536578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042568622", 
          "https://doi.org/10.1007/bf02536578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910320215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052815702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000420838", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076479604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000420839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076479605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077461485", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077868658", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1992-03", 
    "datePublishedReg": "1992-03-01", 
    "description": "Hexadecylphosphocholine (HPC) and octadecylphosphocholine (OPC) show very potent antitumor activity against autochthonous methylnitrosourea-induced mammary carcinomas in rats. The longer-chain and unsaturated homologue erucylphosphocholine (EPC) forms lamellar structures rather than micelles, but nonetheless exhibits antineoplastic activity. Methylnitrosourea was used in the present study to induce autochthonous mammary carcinomas in virgin Sprague-Dawley rats. At 6 and 11 days following oral therapy, the biodistribution of HPC, OPC and EPC was analyzed in the serum, tumor, liver, kidney, lung, small intestine, brain and spleen of rats by high-performance thin-layer chromatography. In contrast to the almost identical tumor response noted, the distribution of the three homologues differed markedly. The serum levels of 50 nmol/ml obtained for OPC and EPC were much lower than the value of 120 nmol/ml measured for HPC. Nevertheless, the quite different serum levels resulted in similar tumor concentrations of about 200 nmol/g for all three of the compounds. Whereas HPC preferably accumulated in the kidney (1 mumol/g), OPC was found at increased concentrations (400 nmol/g) in the spleen, kidney and lung. In spite of the high daily dose of 120 mumol/kg EPC as compared with 51 mumol/kg HPC or OPC, EPC concentrations (100-200 nmol/g) were low in most tissues. High EPC concentrations were found in the small intestine (628 nmol/g). Values of 170 nmol/g were found for HPC and OPC in the brain, whereas the EPC concentration was 120 nmol/g. Obviously, structural modifications in the alkyl chain strongly influence the distribution pattern of alkylphosphocholines in animals. Since EPC yielded the highest tissue-to-serum concentration ratio in tumor tissue (5.1) and the lowest levels in other organs, we conclude that EPC is the most promising candidate for drug development in cancer therapy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00686401", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1088364", 
        "issn": [
          "0344-5704", 
          "1432-0843"
        ], 
        "name": "Cancer Chemotherapy and Pharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "30"
      }
    ], 
    "name": "Alkylphosphocholines: influence of structural variation on biodistribution at antineoplastically active concentrations", 
    "pagination": "105-112", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1b375ae914e4cd02b902ce525d102034c55ac895b93346103d173a626c33dde6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "1600590"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7806519"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00686401"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005712297"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00686401", 
      "https://app.dimensions.ai/details/publication/pub.1005712297"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000372_0000000372/records_117117_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF00686401"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00686401'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00686401'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00686401'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00686401'


 

This table displays all metadata directly associated to this object as RDF triples.

214 TRIPLES      21 PREDICATES      63 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00686401 schema:about N0349b31cd96746ae9f2a21eefc3e996d
2 N052c7da88b294f698047317bcaf7a79f
3 N29b6eef463ae4bf0a56238eeebb1f962
4 N2f12e41490ef403b9eb6ba9fa38a5cb2
5 N5bc05c7c64dd4f67a12cfc6e15f07126
6 N65fc7ee59d0d4c449c2e435f653f271a
7 N73c1237a5e784ec2a5b2ce4d2ab3b883
8 N8c92c25e0c764a9b868dcd97dc8cb7f3
9 N94053dec888e403db2b0116f78d3b9ba
10 Naa62857497eb47dcad6e14ead02d62f1
11 Nacc6bfbdae63430cab73cdd082e74a18
12 Nafa057265a89431d9631ff5e20f8c020
13 Nbe238868a3674c60b28191ad9a7c4988
14 Nc80650944174472aa47d00424573dc5c
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author N087be76518d743ebbf7c77a6f7c49295
18 schema:citation sg:pub.10.1007/bf01612994
19 sg:pub.10.1007/bf02535556
20 sg:pub.10.1007/bf02535558
21 sg:pub.10.1007/bf02536578
22 https://app.dimensions.ai/details/publication/pub.1077461485
23 https://app.dimensions.ai/details/publication/pub.1077868658
24 https://doi.org/10.1002/ijc.2910320215
25 https://doi.org/10.1002/lipi.19880900905
26 https://doi.org/10.1016/0009-3084(88)90031-x
27 https://doi.org/10.1016/0009-3084(88)90032-1
28 https://doi.org/10.1016/0009-3084(88)90033-3
29 https://doi.org/10.1016/0277-5379(88)90336-7
30 https://doi.org/10.1016/0305-7372(87)90023-5
31 https://doi.org/10.1016/0305-7372(90)90053-i
32 https://doi.org/10.1042/bj1400503
33 https://doi.org/10.1159/000216563
34 https://doi.org/10.1159/000216779
35 https://doi.org/10.1159/000420838
36 https://doi.org/10.1159/000420839
37 https://doi.org/10.3109/02841868909111249
38 schema:datePublished 1992-03
39 schema:datePublishedReg 1992-03-01
40 schema:description Hexadecylphosphocholine (HPC) and octadecylphosphocholine (OPC) show very potent antitumor activity against autochthonous methylnitrosourea-induced mammary carcinomas in rats. The longer-chain and unsaturated homologue erucylphosphocholine (EPC) forms lamellar structures rather than micelles, but nonetheless exhibits antineoplastic activity. Methylnitrosourea was used in the present study to induce autochthonous mammary carcinomas in virgin Sprague-Dawley rats. At 6 and 11 days following oral therapy, the biodistribution of HPC, OPC and EPC was analyzed in the serum, tumor, liver, kidney, lung, small intestine, brain and spleen of rats by high-performance thin-layer chromatography. In contrast to the almost identical tumor response noted, the distribution of the three homologues differed markedly. The serum levels of 50 nmol/ml obtained for OPC and EPC were much lower than the value of 120 nmol/ml measured for HPC. Nevertheless, the quite different serum levels resulted in similar tumor concentrations of about 200 nmol/g for all three of the compounds. Whereas HPC preferably accumulated in the kidney (1 mumol/g), OPC was found at increased concentrations (400 nmol/g) in the spleen, kidney and lung. In spite of the high daily dose of 120 mumol/kg EPC as compared with 51 mumol/kg HPC or OPC, EPC concentrations (100-200 nmol/g) were low in most tissues. High EPC concentrations were found in the small intestine (628 nmol/g). Values of 170 nmol/g were found for HPC and OPC in the brain, whereas the EPC concentration was 120 nmol/g. Obviously, structural modifications in the alkyl chain strongly influence the distribution pattern of alkylphosphocholines in animals. Since EPC yielded the highest tissue-to-serum concentration ratio in tumor tissue (5.1) and the lowest levels in other organs, we conclude that EPC is the most promising candidate for drug development in cancer therapy.
41 schema:genre research_article
42 schema:inLanguage en
43 schema:isAccessibleForFree false
44 schema:isPartOf N2427985d088f4d86916ae30dcf00cfd5
45 Nc6d82b1599e441f1b865507a1371d12c
46 sg:journal.1088364
47 schema:name Alkylphosphocholines: influence of structural variation on biodistribution at antineoplastically active concentrations
48 schema:pagination 105-112
49 schema:productId N0e52bd5d79664e4ea5c609d986038c24
50 N48587043457d49db8614a2d5827d3828
51 N55888a4af24340fab6e546e504dd58e1
52 N591692ee305340d69825e39e88b6c9ea
53 Ne32343f8c2d84f12ab53ea4d962be403
54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005712297
55 https://doi.org/10.1007/bf00686401
56 schema:sdDatePublished 2019-04-11T14:19
57 schema:sdLicense https://scigraph.springernature.com/explorer/license/
58 schema:sdPublisher Nf5c8299f1e8a48c7b0d4d67cdcd89a2b
59 schema:url http://link.springer.com/10.1007/BF00686401
60 sgo:license sg:explorer/license/
61 sgo:sdDataset articles
62 rdf:type schema:ScholarlyArticle
63 N0349b31cd96746ae9f2a21eefc3e996d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
64 schema:name Tissue Distribution
65 rdf:type schema:DefinedTerm
66 N052c7da88b294f698047317bcaf7a79f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Structure-Activity Relationship
68 rdf:type schema:DefinedTerm
69 N087be76518d743ebbf7c77a6f7c49295 rdf:first sg:person.01101172752.56
70 rdf:rest N3460531da8284733ba4d3983a658be6b
71 N0e52bd5d79664e4ea5c609d986038c24 schema:name pubmed_id
72 schema:value 1600590
73 rdf:type schema:PropertyValue
74 N2427985d088f4d86916ae30dcf00cfd5 schema:volumeNumber 30
75 rdf:type schema:PublicationVolume
76 N29b6eef463ae4bf0a56238eeebb1f962 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Phosphatidylcholines
78 rdf:type schema:DefinedTerm
79 N2f12e41490ef403b9eb6ba9fa38a5cb2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Rats, Inbred Strains
81 rdf:type schema:DefinedTerm
82 N3460531da8284733ba4d3983a658be6b rdf:first sg:person.01256203524.22
83 rdf:rest Ne1cf09156a87404c8031179206d0f4ab
84 N48587043457d49db8614a2d5827d3828 schema:name doi
85 schema:value 10.1007/bf00686401
86 rdf:type schema:PropertyValue
87 N55888a4af24340fab6e546e504dd58e1 schema:name dimensions_id
88 schema:value pub.1005712297
89 rdf:type schema:PropertyValue
90 N591692ee305340d69825e39e88b6c9ea schema:name nlm_unique_id
91 schema:value 7806519
92 rdf:type schema:PropertyValue
93 N5bc05c7c64dd4f67a12cfc6e15f07126 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Cell Division
95 rdf:type schema:DefinedTerm
96 N65fc7ee59d0d4c449c2e435f653f271a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Chromatography, High Pressure Liquid
98 rdf:type schema:DefinedTerm
99 N73c1237a5e784ec2a5b2ce4d2ab3b883 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Animals
101 rdf:type schema:DefinedTerm
102 N81201185d37d4e9e82c1c136c83ec7b5 rdf:first sg:person.01105334622.36
103 rdf:rest rdf:nil
104 N8c92c25e0c764a9b868dcd97dc8cb7f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Dose-Response Relationship, Drug
106 rdf:type schema:DefinedTerm
107 N94053dec888e403db2b0116f78d3b9ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Rats
109 rdf:type schema:DefinedTerm
110 Naa62857497eb47dcad6e14ead02d62f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Methylnitrosourea
112 rdf:type schema:DefinedTerm
113 Nacc6bfbdae63430cab73cdd082e74a18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Mammary Neoplasms, Experimental
115 rdf:type schema:DefinedTerm
116 Nafa057265a89431d9631ff5e20f8c020 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Male
118 rdf:type schema:DefinedTerm
119 Nbe238868a3674c60b28191ad9a7c4988 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Phosphorylcholine
121 rdf:type schema:DefinedTerm
122 Nc6d82b1599e441f1b865507a1371d12c schema:issueNumber 2
123 rdf:type schema:PublicationIssue
124 Nc80650944174472aa47d00424573dc5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Antineoplastic Agents
126 rdf:type schema:DefinedTerm
127 Ne1cf09156a87404c8031179206d0f4ab rdf:first sg:person.0704572215.43
128 rdf:rest N81201185d37d4e9e82c1c136c83ec7b5
129 Ne32343f8c2d84f12ab53ea4d962be403 schema:name readcube_id
130 schema:value 1b375ae914e4cd02b902ce525d102034c55ac895b93346103d173a626c33dde6
131 rdf:type schema:PropertyValue
132 Nf5c8299f1e8a48c7b0d4d67cdcd89a2b schema:name Springer Nature - SN SciGraph project
133 rdf:type schema:Organization
134 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
135 schema:name Medical and Health Sciences
136 rdf:type schema:DefinedTerm
137 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
138 schema:name Clinical Sciences
139 rdf:type schema:DefinedTerm
140 sg:journal.1088364 schema:issn 0344-5704
141 1432-0843
142 schema:name Cancer Chemotherapy and Pharmacology
143 rdf:type schema:Periodical
144 sg:person.01101172752.56 schema:affiliation https://www.grid.ac/institutes/grid.418140.8
145 schema:familyName Kötting
146 schema:givenName Jochem
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101172752.56
148 rdf:type schema:Person
149 sg:person.01105334622.36 schema:affiliation https://www.grid.ac/institutes/grid.418140.8
150 schema:familyName Eibl
151 schema:givenName Hansjörg
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105334622.36
153 rdf:type schema:Person
154 sg:person.01256203524.22 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
155 schema:familyName Berger
156 schema:givenName Martin R.
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256203524.22
158 rdf:type schema:Person
159 sg:person.0704572215.43 schema:affiliation https://www.grid.ac/institutes/grid.411984.1
160 schema:familyName Unger
161 schema:givenName Clemens
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704572215.43
163 rdf:type schema:Person
164 sg:pub.10.1007/bf01612994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019613494
165 https://doi.org/10.1007/bf01612994
166 rdf:type schema:CreativeWork
167 sg:pub.10.1007/bf02535556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029511128
168 https://doi.org/10.1007/bf02535556
169 rdf:type schema:CreativeWork
170 sg:pub.10.1007/bf02535558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023947179
171 https://doi.org/10.1007/bf02535558
172 rdf:type schema:CreativeWork
173 sg:pub.10.1007/bf02536578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042568622
174 https://doi.org/10.1007/bf02536578
175 rdf:type schema:CreativeWork
176 https://app.dimensions.ai/details/publication/pub.1077461485 schema:CreativeWork
177 https://app.dimensions.ai/details/publication/pub.1077868658 schema:CreativeWork
178 https://doi.org/10.1002/ijc.2910320215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052815702
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1002/lipi.19880900905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040462594
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/0009-3084(88)90031-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032231348
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/0009-3084(88)90032-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012055995
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/0009-3084(88)90033-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008699912
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/0277-5379(88)90336-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033699947
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/0305-7372(87)90023-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039400953
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/0305-7372(90)90053-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1036687880
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1042/bj1400503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020286223
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1159/000216563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023417782
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1159/000216779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035336269
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1159/000420838 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076479604
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1159/000420839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076479605
203 rdf:type schema:CreativeWork
204 https://doi.org/10.3109/02841868909111249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036404133
205 rdf:type schema:CreativeWork
206 https://www.grid.ac/institutes/grid.411984.1 schema:alternateName Universitätsmedizin Göttingen
207 schema:name Abt. Hämatologie/Onkologie, Medizinische Universitätsklinik, Robert-Koch-Strasse 40, D-3400, Göttingen, Germany
208 rdf:type schema:Organization
209 https://www.grid.ac/institutes/grid.418140.8 schema:alternateName Max Planck Institute for Biophysical Chemistry
210 schema:name Max-Planck-Institut für biophysikalische Chemie, Am Fassberg, D-3400, Göttingen, Germany
211 rdf:type schema:Organization
212 https://www.grid.ac/institutes/grid.7497.d schema:alternateName German Cancer Research Center
213 schema:name Institut für Toxikologie u. Chemotherapie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-6900, Heidelberg, Germany
214 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...