Antineoplastic activity and tolerability of a novel heterocyclic alkylphospholipid, D-20133 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-11

AUTHORS

Jurij Stekar, Peter Hilgard, Rainer Voegeli, H. Rainer Maurer, Jürgen Engel, Bernhard Kutscher, Gerhard Nößner, Wolfgang Schumacher

ABSTRACT

Octadecyl-[2-(N-methylpiperidinio)ethyl]-phosphate (OMPEP, D-20133), a heterocyclic analogue of hexadecylphosphocholine (MIL), has been synthesized in an attempt to increase the therapeutic range of the parent compound. The antineoplastic activity of the novel alkylphospholipid was compared with that of MIL in dimethylbenz(a)anthracene-induced mammary carcinoma of the rat. Using tumors of different sizes and repeated daily doses as well as high single doses, we achieved marked remissions with either compound. However, the therapeutic range of OMPEP was broader than that of the parent drug. Furthermore, the emetic potential of OMPEP tested on ferrets was distinctly less pronounced than that of MIL. In vitro the new alkylphospholipid proved to be more active than MIL in all cell lines tested, and its differentiation-inducing capacity turned out to be superior to that of MIL. No hematological toxicity was observed at various OMPEP doses during a 3-week treatment period. More... »

PAGES

437-444

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00685887

DOI

http://dx.doi.org/10.1007/bf00685887

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005452257

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8258191


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