Alkylphosphocholines: a new class of membrane-active anticancer agents View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-03

AUTHORS

P. Hilgard, T. Klenner, J. Stekar, C. Unger

ABSTRACT

From the foregoing it is evident that the experimental profile of miltefosine and alkylphosphocholines is different from that of conventional anticancer agents. Much evidence indicated that the mode of action of alkylphosphocholines was related to plasma-membrane-associated phosphoinositide metabolism. Inhibition of phospholipase C and/or PKC is currently thought to be the main biochemical target of alkylphosphocholines. Considering the great importance of both phosphoinositide metabolism and the regulation of a broad spectrum of cellular functions, including differentiation and invasion, miltefosine could become an interesting new drug. In addition, it may be a tool for further studies into the biochemical pathway of signal transduction in malignant cells. More... »

PAGES

90-95

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00685608

DOI

http://dx.doi.org/10.1007/bf00685608

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025348497

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8485813


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