Protection from ifosfamide-induced alopecia by topical thiols in young rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-07

AUTHORS

Jurij Stekar, Peter Hilgard, Wilfried Holtei, Uwe Riemer

ABSTRACT

An animal model for testing substances that might prevent alopecia induced by oxazaphosphorines has been developed. It is based on the fact that the rat pups experience virtually total hair loss following administration of oxazaphosphorines. Using this model, we showed that epicutaneous treatment with sodium thioglycollate prevented ifosfamide-induced hair loss on the treated area. These experiments indicate that prevention of oxazaphosphorine-induced alopecia in man may be achieved by topical thiols. More... »

PAGES

306-307

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00684892

DOI

http://dx.doi.org/10.1007/bf00684892

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003245849

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2295118


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Cutaneous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alopecia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ifosfamide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Inbred Strains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sulfhydryl Compounds", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Experimental Cancer Research, ASTA Pharma AG, P.O. Box 14 01 29, D-4800, Bielefeld 14, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stekar", 
        "givenName": "Jurij", 
        "id": "sg:person.064602232.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.064602232.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Experimental Cancer Research, ASTA Pharma AG, P.O. Box 14 01 29, D-4800, Bielefeld 14, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hilgard", 
        "givenName": "Peter", 
        "id": "sg:person.01023655171.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023655171.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Experimental Cancer Research, ASTA Pharma AG, P.O. Box 14 01 29, D-4800, Bielefeld 14, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Holtei", 
        "givenName": "Wilfried", 
        "id": "sg:person.01003674767.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003674767.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Experimental Cancer Research, ASTA Pharma AG, P.O. Box 14 01 29, D-4800, Bielefeld 14, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Riemer", 
        "givenName": "Uwe", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0014-2964(66)90042-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009427608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00262579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043631584", 
          "https://doi.org/10.1007/bf00262579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00262579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043631584", 
          "https://doi.org/10.1007/bf00262579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2964(66)90060-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043638120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075480457", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080603458", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1990-07", 
    "datePublishedReg": "1990-07-01", 
    "description": "An animal model for testing substances that might prevent alopecia induced by oxazaphosphorines has been developed. It is based on the fact that the rat pups experience virtually total hair loss following administration of oxazaphosphorines. Using this model, we showed that epicutaneous treatment with sodium thioglycollate prevented ifosfamide-induced hair loss on the treated area. These experiments indicate that prevention of oxazaphosphorine-induced alopecia in man may be achieved by topical thiols.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00684892", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1088364", 
        "issn": [
          "0344-5704", 
          "1432-0843"
        ], 
        "name": "Cancer Chemotherapy and Pharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "25"
      }
    ], 
    "name": "Protection from ifosfamide-induced alopecia by topical thiols in young rats", 
    "pagination": "306-307", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0f762af4e761ab191d0d81ff7a55f6238d2ca9385e9b306047c29667b8fc60e4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2295118"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7806519"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00684892"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003245849"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00684892", 
      "https://app.dimensions.ai/details/publication/pub.1003245849"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000372_0000000372/records_117118_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF00684892"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00684892'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00684892'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00684892'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00684892'


 

This table displays all metadata directly associated to this object as RDF triples.

144 TRIPLES      21 PREDICATES      43 URIs      30 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00684892 schema:about N0752a5c661dd4e0b8fbc170feb6d3377
2 N2fb6203476aa4fdeb11851298634c06f
3 N385c7c8b7d1b4df48653b7840b2bfd9c
4 N46b4111ac2004cbab14023e61825bbd6
5 N5cae0febad8d4c6cbc620ed24b8e15f6
6 N62446ceef6154aa6bb8d73ef89fb69b1
7 N75e72ad816704a978415c3efda28fccf
8 Nc003c2ec2b5340ca9bf7d012006d9f4f
9 Nc60720a808cb4e01a8b8d3c96c677b04
10 anzsrc-for:11
11 anzsrc-for:1103
12 schema:author N8261bcdd072d4cfc9172dfcfa63311ba
13 schema:citation sg:pub.10.1007/bf00262579
14 https://app.dimensions.ai/details/publication/pub.1075480457
15 https://app.dimensions.ai/details/publication/pub.1080603458
16 https://doi.org/10.1016/0014-2964(66)90042-9
17 https://doi.org/10.1016/0014-2964(66)90060-0
18 schema:datePublished 1990-07
19 schema:datePublishedReg 1990-07-01
20 schema:description An animal model for testing substances that might prevent alopecia induced by oxazaphosphorines has been developed. It is based on the fact that the rat pups experience virtually total hair loss following administration of oxazaphosphorines. Using this model, we showed that epicutaneous treatment with sodium thioglycollate prevented ifosfamide-induced hair loss on the treated area. These experiments indicate that prevention of oxazaphosphorine-induced alopecia in man may be achieved by topical thiols.
21 schema:genre research_article
22 schema:inLanguage en
23 schema:isAccessibleForFree false
24 schema:isPartOf Naa2d78eaf35f408db3d3d6a3830aaaa0
25 Nce8e14804b8346679238d6360222e8cd
26 sg:journal.1088364
27 schema:name Protection from ifosfamide-induced alopecia by topical thiols in young rats
28 schema:pagination 306-307
29 schema:productId N177a0aca187b49dea17a7923e7663a5e
30 N3bc6ab703bbd446a97a3598b47ce8ca5
31 N5ecea0faa0224035a4d1a2b42a501f41
32 N7e7379d70ba64dd78d9a198f7bde9295
33 Nb111d0c5864e4040ab341a19c95a671b
34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003245849
35 https://doi.org/10.1007/bf00684892
36 schema:sdDatePublished 2019-04-11T14:19
37 schema:sdLicense https://scigraph.springernature.com/explorer/license/
38 schema:sdPublisher Ne81e276e66404b758fb358fcff68e1bf
39 schema:url http://link.springer.com/10.1007/BF00684892
40 sgo:license sg:explorer/license/
41 sgo:sdDataset articles
42 rdf:type schema:ScholarlyArticle
43 N0752a5c661dd4e0b8fbc170feb6d3377 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
44 schema:name Rats
45 rdf:type schema:DefinedTerm
46 N177a0aca187b49dea17a7923e7663a5e schema:name dimensions_id
47 schema:value pub.1003245849
48 rdf:type schema:PropertyValue
49 N1c5013855bdb4cf9a9c3d2f352e972ba schema:name Department of Experimental Cancer Research, ASTA Pharma AG, P.O. Box 14 01 29, D-4800, Bielefeld 14, Federal Republic of Germany
50 rdf:type schema:Organization
51 N278abba02f984a21980620f89a72d50b rdf:first sg:person.01003674767.06
52 rdf:rest N521a6845688c4641a7276454623778bb
53 N2fb6203476aa4fdeb11851298634c06f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
54 schema:name Ifosfamide
55 rdf:type schema:DefinedTerm
56 N385c7c8b7d1b4df48653b7840b2bfd9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
57 schema:name Male
58 rdf:type schema:DefinedTerm
59 N3bc6ab703bbd446a97a3598b47ce8ca5 schema:name readcube_id
60 schema:value 0f762af4e761ab191d0d81ff7a55f6238d2ca9385e9b306047c29667b8fc60e4
61 rdf:type schema:PropertyValue
62 N46b4111ac2004cbab14023e61825bbd6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Animals
64 rdf:type schema:DefinedTerm
65 N521a6845688c4641a7276454623778bb rdf:first Na519bec2264c4eeb9ad66a05a7ece848
66 rdf:rest rdf:nil
67 N5cae0febad8d4c6cbc620ed24b8e15f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Administration, Cutaneous
69 rdf:type schema:DefinedTerm
70 N5ecea0faa0224035a4d1a2b42a501f41 schema:name doi
71 schema:value 10.1007/bf00684892
72 rdf:type schema:PropertyValue
73 N62446ceef6154aa6bb8d73ef89fb69b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Female
75 rdf:type schema:DefinedTerm
76 N75e72ad816704a978415c3efda28fccf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Sulfhydryl Compounds
78 rdf:type schema:DefinedTerm
79 N7e7379d70ba64dd78d9a198f7bde9295 schema:name pubmed_id
80 schema:value 2295118
81 rdf:type schema:PropertyValue
82 N8261bcdd072d4cfc9172dfcfa63311ba rdf:first sg:person.064602232.91
83 rdf:rest Ne49e28ec527b4b2cb9a1da9a9c19422f
84 N95203b7e34d3469c801e69be93de52e8 schema:name Department of Experimental Cancer Research, ASTA Pharma AG, P.O. Box 14 01 29, D-4800, Bielefeld 14, Federal Republic of Germany
85 rdf:type schema:Organization
86 Na17d0019382346d8b6a411395bf68b08 schema:name Department of Experimental Cancer Research, ASTA Pharma AG, P.O. Box 14 01 29, D-4800, Bielefeld 14, Federal Republic of Germany
87 rdf:type schema:Organization
88 Na31dc332a3574605940e69089384f818 schema:name Department of Experimental Cancer Research, ASTA Pharma AG, P.O. Box 14 01 29, D-4800, Bielefeld 14, Federal Republic of Germany
89 rdf:type schema:Organization
90 Na519bec2264c4eeb9ad66a05a7ece848 schema:affiliation N95203b7e34d3469c801e69be93de52e8
91 schema:familyName Riemer
92 schema:givenName Uwe
93 rdf:type schema:Person
94 Naa2d78eaf35f408db3d3d6a3830aaaa0 schema:issueNumber 4
95 rdf:type schema:PublicationIssue
96 Nb111d0c5864e4040ab341a19c95a671b schema:name nlm_unique_id
97 schema:value 7806519
98 rdf:type schema:PropertyValue
99 Nc003c2ec2b5340ca9bf7d012006d9f4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Alopecia
101 rdf:type schema:DefinedTerm
102 Nc60720a808cb4e01a8b8d3c96c677b04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Rats, Inbred Strains
104 rdf:type schema:DefinedTerm
105 Nce8e14804b8346679238d6360222e8cd schema:volumeNumber 25
106 rdf:type schema:PublicationVolume
107 Ne49e28ec527b4b2cb9a1da9a9c19422f rdf:first sg:person.01023655171.21
108 rdf:rest N278abba02f984a21980620f89a72d50b
109 Ne81e276e66404b758fb358fcff68e1bf schema:name Springer Nature - SN SciGraph project
110 rdf:type schema:Organization
111 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
112 schema:name Medical and Health Sciences
113 rdf:type schema:DefinedTerm
114 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
115 schema:name Clinical Sciences
116 rdf:type schema:DefinedTerm
117 sg:journal.1088364 schema:issn 0344-5704
118 1432-0843
119 schema:name Cancer Chemotherapy and Pharmacology
120 rdf:type schema:Periodical
121 sg:person.01003674767.06 schema:affiliation Na31dc332a3574605940e69089384f818
122 schema:familyName Holtei
123 schema:givenName Wilfried
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003674767.06
125 rdf:type schema:Person
126 sg:person.01023655171.21 schema:affiliation Na17d0019382346d8b6a411395bf68b08
127 schema:familyName Hilgard
128 schema:givenName Peter
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023655171.21
130 rdf:type schema:Person
131 sg:person.064602232.91 schema:affiliation N1c5013855bdb4cf9a9c3d2f352e972ba
132 schema:familyName Stekar
133 schema:givenName Jurij
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.064602232.91
135 rdf:type schema:Person
136 sg:pub.10.1007/bf00262579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043631584
137 https://doi.org/10.1007/bf00262579
138 rdf:type schema:CreativeWork
139 https://app.dimensions.ai/details/publication/pub.1075480457 schema:CreativeWork
140 https://app.dimensions.ai/details/publication/pub.1080603458 schema:CreativeWork
141 https://doi.org/10.1016/0014-2964(66)90042-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009427608
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1016/0014-2964(66)90060-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043638120
144 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...