Lack of prognostic value of epidermal growth factor receptor in a series of 229 T1/T2, N0/N1 breast cancers, with well ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-01

AUTHORS

M. Bolla, M. Chedin, M. Colonna, J. Marron-Charrière, B. Rostaing-Puissant, D. Pasquier, M. H. Panh, P. Winckel, E. M. Chambaz

ABSTRACT

The prognostic value of epidermal growth factor receptor (EGF-R) was prospectively assessed in a series of 229 clinical T1-T2, N0-N1 breast carcinomas diagnosed between May 1987 and October 1989. EGF-R expression was determined by measuring the specific Bmax of 125I EGF to tumor plasma membrane preparations. Tumor with a Bmax > or = 3 fmol/mg of protein were considered positive with regard to EGF-R expression. With a median follow-up of 34 months, the 3-year overall and disease-free survivals are respectively 92% and 88% for EGF-R < or = 3, and 91% and 86% EGF-R > 3 fmol, showing no significant difference, even when comparing axillary lymph node status. We did not succeed in finding an EGF-R cut-off value which might be significant in univariate analysis. Multivariate analysis of our data indicates that pT (p = 0.001), pN (p = 0.04), and Scarff-Bloom grade (p = 0.04) are the only significant predictors of disease-free survival among the parameters investigated in this study. More... »

PAGES

265-270

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00666480

DOI

http://dx.doi.org/10.1007/bf00666480

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8049460


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