Detection of c-erbB-2 gene amplification in nipple discharge by means of polymerase chain reaction View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-01

AUTHORS

Kazuyoshi Motomura, Hiroki Koyama, Shinzaburo Noguchi, Hideo Inaji, Chihiro Azuma

ABSTRACT

In a patient with non-palpable breast carcinoma, c-erbB-2 gene amplification was detected by means of polymerase chain reaction (PCR) in the small number of breast carcinoma cells present in nipple discharge. Amplification of the c-erbB-2 gene is more frequent in carcinoma in situ than in invasive types. Detection by a PCR-based method may help diagnose non-palpable breast carcinoma with nipple discharge. Since this gene amplification is related to high proliferation, it might provide useful preoperative information regarding intraductal carcinoma of comedo type and predict responses to chemotherapy. More... »

PAGES

89-92

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00666075

DOI

http://dx.doi.org/10.1007/bf00666075

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053423234

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7749137


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