Protein tyrosine kinase activity as a prognostic parameter in breast cancer, a pilot study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-01

AUTHORS

M. Bolla, B. Rostaing-Puissant, M. Chedin, C. Souvignet, J. Marron-Charriere, M. Colonna, E. Berland, E. M. Chambaz

ABSTRACT

Protein tyrosine kinase (PTK) activity was assayed in cytosolic extracts from normal breast tissue, benign tumors, and 84 T1-T2, N0-N1 M0, breast carcinomas. Normal breast tissue extracts yielded an average value of 1.9 +/- 1.1 pmol 32P incorporated/min/mg protein, whereas a mean of 12.5 +/- 6.1 was obtained for cancer samples. With a median follow-up of 34 months, in the series of 40 patients classified N-, PTK positive patients presented a significantly smaller 3-year disease free survival than the PTK negative ones. Multivariate analysis shows that PTK activity emerges as a potential prognostic factor in breast cancer (p = 0.02). These preliminary results will be updated on a bigger cohort of patients. More... »

PAGES

283-287

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00665806

DOI

http://dx.doi.org/10.1007/bf00665806

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033381167

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8251653


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