Nm23 and breast cancer metastasis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-01

AUTHORS

Patricia S. Steeg, Abel De La Rosa, Ursula Flatow, Nicholas J. MacDonald, Mary Benedict, Alvaro Leone

ABSTRACT

The majority of breast cancer patients succumb to metastatic disease. We summarize published and recent research concerning the nm23 gene in breast cancer metastasis. In a murine developmental study, nm23 expression increased with the functional differentiation of the mammary gland in nulliparous and pregnant animals. In human breast cancer, five studies have now demonstrated a significant association between reduced nm23 expression, at the RNA or protein levels, and aggressive tumor behavior. Nm23-negative tumor cells have been observed in comedo ductal carcinoma in situ lesions in two independent studies, indicating that decreases in nm23 expression begin prior to actual histologically identifiable invasion. Transfection studies, in which human nm23-H1 cDNA was expressed in the metastatic human MDA-MB-435 breast carcinoma cell line, indicate that nm23-H1 suppresses in vivo metastatic potential by 50-90%. Finally, our data in melanoma and breast carcinoma transfection systems suggest that the biochemical mechanism of nm23 suppressive activity is likely not due to its nucleoside diphosphate kinase activity, association with GAP proteins, or secretion from cells. More... »

PAGES

175-187

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00662142

DOI

http://dx.doi.org/10.1007/bf00662142

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8347849


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