Effects of diuretics on plasma lipoproteins in healthy men View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1980-07

AUTHORS

C. Joos, H. Kewitz, D. Reinhold-Kourniati

ABSTRACT

The fasting level of plasma very low density lipoproteins (VLDL) was increased by 30 to 50% in 12 healthy male volunteers treated with daily oral doses of hydrochlorothiazide 100 mg, chlorthalidone 100 mg or furosemide 80 mg for 3 weeks in a cross-over trial. Hydrochlorothiazide and chlorthalidone, but not furosemide, caused a 10% increase in cholesterol in the low density lipoproteins (LDL), whereas triglycerides and phospholipids in this fraction remained unchanged. High density lipoproteins (HDL) were not affected by any of the diuretics. Free palmitic and oleic acid in plasma were also increased during the treatment, perhaps because of an accumulation of cyclic 3′5′-AMP due either to the inhibitory action of diuretics on phosphodiesterase, or to secondary activation of the sympathetic nervous systems. This would activate lipolysis in fat tissue, which in turn may induce VLDL synthesis in the liver. Each of the diuretics caused a similar rise of 20 to 30% in the mean plasma uric acid, the which could not be correlated with either triglycerides or cholesterol. Plasma sodium was increased by 2% only by furosemide, whereas potassium was decreased by 15 and 19% by hydrochlorothiazide and chlorthalidone, respectively, but not by furosemide. Mean plasma creatinine rose by 3.5% on treatment with furosemide, and by 6% with the other two diuretics. Mean body weight was reduced by 1,4 to 2,0% during treatment. No change in fasting blood sugar, plasma protein level or hematocrit was found. More... »

PAGES

251-257

References to SciGraph publications

  • 1972. Effects of Catecholamines on Metabolism in CATECHOLAMINES
  • 1966-01. Ursachen der Störungen im Kohlenhydratstoffwechsel unter dem Einfluß sulfonamidierter Diuretica in ARCHIV FÜR PHARMAKOLOGIE UND EXPERIMENTELLE PATHOLOGIE
  • 1966-03. Eine neue Bestimmung der Neutralfette im Blutserum und Gewebe in JOURNAL OF MOLECULAR MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00625798

    DOI

    http://dx.doi.org/10.1007/bf00625798

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1029985014

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6995127


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1101", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Biochemistry and Metabolomics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Administration, Oral", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chlorthalidone", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cholesterol", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Clinical Trials as Topic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diuretics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fatty Acids, Nonesterified", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Furosemide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hydrochlorothiazide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lipoproteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lipoproteins, HDL", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lipoproteins, LDL", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lipoproteins, VLDL", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phospholipids", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Placebos", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sodium Chloride Symporter Inhibitors", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Department of Clinical Pharmacology, Free University of Berlin, Klinikum Steglitz, Berlin, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Joos", 
            "givenName": "C.", 
            "id": "sg:person.01370452303.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370452303.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Clinical Pharmacology, Free University of Berlin, Klinikum Steglitz, Berlin, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kewitz", 
            "givenName": "H.", 
            "id": "sg:person.0577236243.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577236243.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Clinical Pharmacology, Free University of Berlin, Klinikum Steglitz, Berlin, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Reinhold-Kourniati", 
            "givenName": "D.", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1177/000331977602701205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002523464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/000331977602701205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002523464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.1964.03070220062023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006015100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.1960.tb20075.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006784252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00593171", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010779101", 
              "https://doi.org/10.1007/bf00593171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00593171", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010779101", 
              "https://doi.org/10.1007/bf00593171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/b978-1-4831-9942-9.50008-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013593729"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0021-9150(75)90072-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016044205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1515/cclm.1975.13.9.407", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017592544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1515/cclm.1975.13.9.407", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017592544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-65249-3_11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021538780", 
              "https://doi.org/10.1007/978-3-642-65249-3_11"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(77)90975-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026390730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0002-9343(76)90156-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032152782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1552-4604.1975.tb01483.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034174398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci108229", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036021986"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1515/cclm.1974.12.9.403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036691854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1515/cclm.1974.12.9.403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036691854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs055325s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037983031"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs055325s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037983031"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs047009pa", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040558120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs047009pa", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040558120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0002-9343(78)90177-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049451893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01747716", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053519233", 
              "https://doi.org/10.1007/bf01747716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01747716", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053519233", 
              "https://doi.org/10.1007/bf01747716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076279896", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078454423", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1980-07", 
        "datePublishedReg": "1980-07-01", 
        "description": "The fasting level of plasma very low density lipoproteins (VLDL) was increased by 30 to 50% in 12 healthy male volunteers treated with daily oral doses of hydrochlorothiazide 100 mg, chlorthalidone 100 mg or furosemide 80 mg for 3 weeks in a cross-over trial. Hydrochlorothiazide and chlorthalidone, but not furosemide, caused a 10% increase in cholesterol in the low density lipoproteins (LDL), whereas triglycerides and phospholipids in this fraction remained unchanged. High density lipoproteins (HDL) were not affected by any of the diuretics. Free palmitic and oleic acid in plasma were also increased during the treatment, perhaps because of an accumulation of cyclic 3\u20325\u2032-AMP due either to the inhibitory action of diuretics on phosphodiesterase, or to secondary activation of the sympathetic nervous systems. This would activate lipolysis in fat tissue, which in turn may induce VLDL synthesis in the liver. Each of the diuretics caused a similar rise of 20 to 30% in the mean plasma uric acid, the which could not be correlated with either triglycerides or cholesterol. Plasma sodium was increased by 2% only by furosemide, whereas potassium was decreased by 15 and 19% by hydrochlorothiazide and chlorthalidone, respectively, but not by furosemide. Mean plasma creatinine rose by 3.5% on treatment with furosemide, and by 6% with the other two diuretics. Mean body weight was reduced by 1,4 to 2,0% during treatment. No change in fasting blood sugar, plasma protein level or hematocrit was found.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/bf00625798", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1054337", 
            "issn": [
              "0031-6970", 
              "1432-1041"
            ], 
            "name": "European Journal of Clinical Pharmacology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "17"
          }
        ], 
        "name": "Effects of diuretics on plasma lipoproteins in healthy men", 
        "pagination": "251-257", 
        "productId": [
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/bf00625798"
            ]
          }, 
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "8ed839c147beec875e13af45d5936bda85b451a6b1ed373bb3ab1da9463c13f2"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1029985014"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "1256165"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "6995127"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/bf00625798", 
          "https://app.dimensions.ai/details/publication/pub.1029985014"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-15T08:59", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000375_0000000375/records_91432_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007/BF00625798"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00625798'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00625798'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00625798'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00625798'


     

    This table displays all metadata directly associated to this object as RDF triples.

    215 TRIPLES      21 PREDICATES      66 URIs      39 LITERALS      27 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/bf00625798 schema:about N29563c1a47f249b59308913ba78e42a3
    2 N54e5f7de145046cf8711087a7f854123
    3 N55cd18d0b9cb4c30bed2d7db3aca353d
    4 N587cd2a6d0eb43f2af696574cb26fbd7
    5 N5dd247c47c36438894b99941a7126645
    6 N888269cdeb18407087ee9031d0feba80
    7 N980cc739796142b6ad50d499cb8b16cc
    8 N9bc50636fa6c4e88a07680324bfa719c
    9 Na08540f7ddce416a8ffcff7f29176a7e
    10 Nb3f9642b9fef4c0a91b9c09c0b8985ec
    11 Nb5ddf4b3fa4d44dcb987a72a588bd90f
    12 Nd835457fa5484b9596f7a87d2ed1665f
    13 Nde34e5d2e70f4142b5cf74f4a5730480
    14 Ne442b63c6e874d439843ea9879fd3ca5
    15 Ne7c230d18c4e45afaf109dc7f96f540e
    16 Ne950afc768064513b70b42338837467e
    17 Nf65ee8036f57422a8fad9f6366e3254c
    18 Nfb84ce2e398d490797666a42dcdf693e
    19 anzsrc-for:11
    20 anzsrc-for:1101
    21 schema:author N2cae242017954a7db1928e72739c1950
    22 schema:citation sg:pub.10.1007/978-3-642-65249-3_11
    23 sg:pub.10.1007/bf00593171
    24 sg:pub.10.1007/bf01747716
    25 https://app.dimensions.ai/details/publication/pub.1076279896
    26 https://app.dimensions.ai/details/publication/pub.1078454423
    27 https://doi.org/10.1001/jama.1964.03070220062023
    28 https://doi.org/10.1002/j.1552-4604.1975.tb01483.x
    29 https://doi.org/10.1016/0002-9343(76)90156-x
    30 https://doi.org/10.1016/0002-9343(78)90177-8
    31 https://doi.org/10.1016/0021-9150(75)90072-6
    32 https://doi.org/10.1016/b978-1-4831-9942-9.50008-5
    33 https://doi.org/10.1016/s0140-6736(77)90975-8
    34 https://doi.org/10.1042/cs047009pa
    35 https://doi.org/10.1042/cs055325s
    36 https://doi.org/10.1111/j.1749-6632.1960.tb20075.x
    37 https://doi.org/10.1172/jci108229
    38 https://doi.org/10.1177/000331977602701205
    39 https://doi.org/10.1515/cclm.1974.12.9.403
    40 https://doi.org/10.1515/cclm.1975.13.9.407
    41 schema:datePublished 1980-07
    42 schema:datePublishedReg 1980-07-01
    43 schema:description The fasting level of plasma very low density lipoproteins (VLDL) was increased by 30 to 50% in 12 healthy male volunteers treated with daily oral doses of hydrochlorothiazide 100 mg, chlorthalidone 100 mg or furosemide 80 mg for 3 weeks in a cross-over trial. Hydrochlorothiazide and chlorthalidone, but not furosemide, caused a 10% increase in cholesterol in the low density lipoproteins (LDL), whereas triglycerides and phospholipids in this fraction remained unchanged. High density lipoproteins (HDL) were not affected by any of the diuretics. Free palmitic and oleic acid in plasma were also increased during the treatment, perhaps because of an accumulation of cyclic 3′5′-AMP due either to the inhibitory action of diuretics on phosphodiesterase, or to secondary activation of the sympathetic nervous systems. This would activate lipolysis in fat tissue, which in turn may induce VLDL synthesis in the liver. Each of the diuretics caused a similar rise of 20 to 30% in the mean plasma uric acid, the which could not be correlated with either triglycerides or cholesterol. Plasma sodium was increased by 2% only by furosemide, whereas potassium was decreased by 15 and 19% by hydrochlorothiazide and chlorthalidone, respectively, but not by furosemide. Mean plasma creatinine rose by 3.5% on treatment with furosemide, and by 6% with the other two diuretics. Mean body weight was reduced by 1,4 to 2,0% during treatment. No change in fasting blood sugar, plasma protein level or hematocrit was found.
    44 schema:genre research_article
    45 schema:inLanguage en
    46 schema:isAccessibleForFree false
    47 schema:isPartOf N705335c1b10b4858972b360be6a30a2e
    48 Nee30c6a8b21a4cee9e0e7281b5f0f141
    49 sg:journal.1054337
    50 schema:name Effects of diuretics on plasma lipoproteins in healthy men
    51 schema:pagination 251-257
    52 schema:productId N0e72fb7185f94bc384efeb349fc7b58c
    53 N1587180d228742fb954024c3ce93917f
    54 N2918ba28b9cb4d2b8881a5ebdc4da5fd
    55 N5e7a099428ad4bfb88f080c1b3f7c457
    56 N747981ed377445e59f1f5728b905a3b6
    57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029985014
    58 https://doi.org/10.1007/bf00625798
    59 schema:sdDatePublished 2019-04-15T08:59
    60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    61 schema:sdPublisher Ne649a3445f014d9dad5706f8acb50cef
    62 schema:url http://link.springer.com/10.1007/BF00625798
    63 sgo:license sg:explorer/license/
    64 sgo:sdDataset articles
    65 rdf:type schema:ScholarlyArticle
    66 N0e72fb7185f94bc384efeb349fc7b58c schema:name nlm_unique_id
    67 schema:value 1256165
    68 rdf:type schema:PropertyValue
    69 N1587180d228742fb954024c3ce93917f schema:name pubmed_id
    70 schema:value 6995127
    71 rdf:type schema:PropertyValue
    72 N181ba6dae30e4083bf5d0a275bb3e22d rdf:first sg:person.0577236243.18
    73 rdf:rest N714b85133e3f47a2aabc2d1451a76553
    74 N2918ba28b9cb4d2b8881a5ebdc4da5fd schema:name dimensions_id
    75 schema:value pub.1029985014
    76 rdf:type schema:PropertyValue
    77 N29563c1a47f249b59308913ba78e42a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    78 schema:name Placebos
    79 rdf:type schema:DefinedTerm
    80 N2cae242017954a7db1928e72739c1950 rdf:first sg:person.01370452303.55
    81 rdf:rest N181ba6dae30e4083bf5d0a275bb3e22d
    82 N54e5f7de145046cf8711087a7f854123 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    83 schema:name Humans
    84 rdf:type schema:DefinedTerm
    85 N55cd18d0b9cb4c30bed2d7db3aca353d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    86 schema:name Cholesterol
    87 rdf:type schema:DefinedTerm
    88 N587cd2a6d0eb43f2af696574cb26fbd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    89 schema:name Lipoproteins, LDL
    90 rdf:type schema:DefinedTerm
    91 N5dd247c47c36438894b99941a7126645 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    92 schema:name Hydrochlorothiazide
    93 rdf:type schema:DefinedTerm
    94 N5e7a099428ad4bfb88f080c1b3f7c457 schema:name doi
    95 schema:value 10.1007/bf00625798
    96 rdf:type schema:PropertyValue
    97 N705335c1b10b4858972b360be6a30a2e schema:issueNumber 4
    98 rdf:type schema:PublicationIssue
    99 N714b85133e3f47a2aabc2d1451a76553 rdf:first N7cdf5fa16b7a4b76b5d51233de962f3c
    100 rdf:rest rdf:nil
    101 N747981ed377445e59f1f5728b905a3b6 schema:name readcube_id
    102 schema:value 8ed839c147beec875e13af45d5936bda85b451a6b1ed373bb3ab1da9463c13f2
    103 rdf:type schema:PropertyValue
    104 N7c1063f3c18044cfac28b83ec9e9dfa1 schema:name Department of Clinical Pharmacology, Free University of Berlin, Klinikum Steglitz, Berlin, Germany
    105 rdf:type schema:Organization
    106 N7cdf5fa16b7a4b76b5d51233de962f3c schema:affiliation N7c1063f3c18044cfac28b83ec9e9dfa1
    107 schema:familyName Reinhold-Kourniati
    108 schema:givenName D.
    109 rdf:type schema:Person
    110 N888269cdeb18407087ee9031d0feba80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Sodium Chloride Symporter Inhibitors
    112 rdf:type schema:DefinedTerm
    113 N980cc739796142b6ad50d499cb8b16cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Adult
    115 rdf:type schema:DefinedTerm
    116 N9bc50636fa6c4e88a07680324bfa719c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Lipoproteins, VLDL
    118 rdf:type schema:DefinedTerm
    119 Na08540f7ddce416a8ffcff7f29176a7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Administration, Oral
    121 rdf:type schema:DefinedTerm
    122 Nb3f9642b9fef4c0a91b9c09c0b8985ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Lipoproteins, HDL
    124 rdf:type schema:DefinedTerm
    125 Nb5ddf4b3fa4d44dcb987a72a588bd90f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Diuretics
    127 rdf:type schema:DefinedTerm
    128 Nd835457fa5484b9596f7a87d2ed1665f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Lipoproteins
    130 rdf:type schema:DefinedTerm
    131 Nde34e5d2e70f4142b5cf74f4a5730480 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Furosemide
    133 rdf:type schema:DefinedTerm
    134 Ne23252d074e84f38bedec60a2fd9aaf9 schema:name Department of Clinical Pharmacology, Free University of Berlin, Klinikum Steglitz, Berlin, Germany
    135 rdf:type schema:Organization
    136 Ne2e402711d3c4de59c340a35dca335cf schema:name Department of Clinical Pharmacology, Free University of Berlin, Klinikum Steglitz, Berlin, Germany
    137 rdf:type schema:Organization
    138 Ne442b63c6e874d439843ea9879fd3ca5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Chlorthalidone
    140 rdf:type schema:DefinedTerm
    141 Ne649a3445f014d9dad5706f8acb50cef schema:name Springer Nature - SN SciGraph project
    142 rdf:type schema:Organization
    143 Ne7c230d18c4e45afaf109dc7f96f540e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Male
    145 rdf:type schema:DefinedTerm
    146 Ne950afc768064513b70b42338837467e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Clinical Trials as Topic
    148 rdf:type schema:DefinedTerm
    149 Nee30c6a8b21a4cee9e0e7281b5f0f141 schema:volumeNumber 17
    150 rdf:type schema:PublicationVolume
    151 Nf65ee8036f57422a8fad9f6366e3254c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Phospholipids
    153 rdf:type schema:DefinedTerm
    154 Nfb84ce2e398d490797666a42dcdf693e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Fatty Acids, Nonesterified
    156 rdf:type schema:DefinedTerm
    157 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    158 schema:name Medical and Health Sciences
    159 rdf:type schema:DefinedTerm
    160 anzsrc-for:1101 schema:inDefinedTermSet anzsrc-for:
    161 schema:name Medical Biochemistry and Metabolomics
    162 rdf:type schema:DefinedTerm
    163 sg:journal.1054337 schema:issn 0031-6970
    164 1432-1041
    165 schema:name European Journal of Clinical Pharmacology
    166 rdf:type schema:Periodical
    167 sg:person.01370452303.55 schema:affiliation Ne2e402711d3c4de59c340a35dca335cf
    168 schema:familyName Joos
    169 schema:givenName C.
    170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370452303.55
    171 rdf:type schema:Person
    172 sg:person.0577236243.18 schema:affiliation Ne23252d074e84f38bedec60a2fd9aaf9
    173 schema:familyName Kewitz
    174 schema:givenName H.
    175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577236243.18
    176 rdf:type schema:Person
    177 sg:pub.10.1007/978-3-642-65249-3_11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021538780
    178 https://doi.org/10.1007/978-3-642-65249-3_11
    179 rdf:type schema:CreativeWork
    180 sg:pub.10.1007/bf00593171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010779101
    181 https://doi.org/10.1007/bf00593171
    182 rdf:type schema:CreativeWork
    183 sg:pub.10.1007/bf01747716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053519233
    184 https://doi.org/10.1007/bf01747716
    185 rdf:type schema:CreativeWork
    186 https://app.dimensions.ai/details/publication/pub.1076279896 schema:CreativeWork
    187 https://app.dimensions.ai/details/publication/pub.1078454423 schema:CreativeWork
    188 https://doi.org/10.1001/jama.1964.03070220062023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006015100
    189 rdf:type schema:CreativeWork
    190 https://doi.org/10.1002/j.1552-4604.1975.tb01483.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034174398
    191 rdf:type schema:CreativeWork
    192 https://doi.org/10.1016/0002-9343(76)90156-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032152782
    193 rdf:type schema:CreativeWork
    194 https://doi.org/10.1016/0002-9343(78)90177-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049451893
    195 rdf:type schema:CreativeWork
    196 https://doi.org/10.1016/0021-9150(75)90072-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016044205
    197 rdf:type schema:CreativeWork
    198 https://doi.org/10.1016/b978-1-4831-9942-9.50008-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013593729
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1016/s0140-6736(77)90975-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026390730
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1042/cs047009pa schema:sameAs https://app.dimensions.ai/details/publication/pub.1040558120
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1042/cs055325s schema:sameAs https://app.dimensions.ai/details/publication/pub.1037983031
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1111/j.1749-6632.1960.tb20075.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006784252
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.1172/jci108229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036021986
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1177/000331977602701205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002523464
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1515/cclm.1974.12.9.403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036691854
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1515/cclm.1975.13.9.407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017592544
    215 rdf:type schema:CreativeWork
     




    Preview window. Press ESC to close (or click here)


    ...