Influence of digestive secretions and food on intestinal absorption of nicardipine View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-03

AUTHORS

J. C. Delchier, M. Guerret, N. Vidon, C. Dubray, D. Lavene

ABSTRACT

The role of digestive absorption in the pharmacokinetics of nicardipine has been studied by the perfusion technique. Nicardipine (40 mg) was perfused in six healthy subjects at 5 ml/min for 2 h either in isotonic saline with (Experiment A) or without (B) an occlusive balloon isolating the test segment from digestive secretions, or in a nutrient solution (Experiment C). In Experiments A and B, 100% of nicardipine was absorbed from the jejunal lumen in a 25 cm test segment and in Experiment C it was slightly lower (94%). There was no relationship between the absorption of nicardipine and water movement or bile salt concentration in the jejunum. Nicardipine was already present in the first plasma sample taken after 15 min and the peak level was found at the end of the perfusion. The areas under the curves differed widely between subjects, because of interindividual variation in the first pass effect, but they were similar in Experiments A, B and C. The experimental data showed a good fit to a mode involving a two-phase absorption process. The first phase was associated with intestinal perfusion (zero order process) and the second with passage across the intestinal wall (1st order process). In three further healthy subjects, nicardipine in saline was perfused in the jejunum and then in the ileum on consecutive days. Mean plasma levels over time were similar. The study showed that absorption of nicardipine both from the jejunum and the ileum was complete and was especially rapid. The food-induced change in the kinetics of absorption from the jejunum was too small to affect the pharmacokinetic parameters of nicardipine. More... »

PAGES

165-171

References to SciGraph publications

  • 1986-05. Metoprolol in DRUGS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00614554

    DOI

    http://dx.doi.org/10.1007/bf00614554

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047699760

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3383989


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