Effect of prednisolone and ketotifen onβ2-adrenoceptors in asthmatic patients receivingβ2-bronchodilators View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-03

AUTHORS

O. E. Brodde, U. Howe, S. Egerszegi, N. Konietzko, M. C. Michel

ABSTRACT

In 13 patients with bronchial asthma, who were onβ2-adrenergic bronchodilator therapy, the effects of prednisolone and ketotifen on lymphocyteβ2-adrenoceptor density and -responsiveness were investigated. The mean lymphocyteβ2-adrenoceptor density and -responsiveness was significantly lower than in healthy controls, presumably due to the long-termβ2-adrenergic bronchodilator treatment. Both prednisolone 100 mg i.v. and ketotifen 1 mg b.d.p.o. for 6 days rapidly improved lymphocyteβ2-adrenoceptor function. 16 h after prednisolone and about 6 days after the first dose of ketotifen lymphocyteβ2-adrenoceptor density and-responsiveness had risen to values within the range in normal volunteers.The improvement of lymphocyteβ2-adrenoceptor function was accompanied by a significant increase in peak expiratory flow rate before and after inhalation of salbutamol.It is concluded that prednisolone and ketotifen may act beneficially on the recovery ofβ2-adrenoceptor responsiveness toβ2-adrenergic bronchodilators in tolerant asthmatic patients. More... »

PAGES

145-150

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00614551

DOI

http://dx.doi.org/10.1007/bf00614551

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009739834

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2898369


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196 schema:name Biochemical Research Laboratory, Medizinische Klinik und Poliklinik, Division of Renal and Hypertensive Diseases, University of Essen, Essen, Germany
197 rdf:type schema:Organization
 




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