Inhibition and induction of metronidazole and antipyrine metabolism View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-01

AUTHORS

S. Loft, J. Sonne, H. E. Poulsen, K. T. Petersen, B. G. Jørgensen, M. Døssing

ABSTRACT

The effect of cimetidine, antipyrine and phenobarbitone on the pharmacokinetics of intravenous metronidazole and oral antipyrine has been examined in 7 healthy volunteers. The administration of cimetidine for 24 h before and throughout the sampling period failed to alter the total clearance of metronidazole or the rate of formation of the hydroxy metabolite, whereas the total and partial clearances of antipyrine were decreased 0.74 and 0.6-0.7-fold, respectively. Seven days of phenobarbitone or antipyrine administration increased the total clearance of metronidazole 1.51- and 1.86-fold, respectively, and the total antipyrine clearance was 1.22 or 1.46-fold increased, respectively. The rate of metronidazole hydroxylation was significantly enhanced by both enzyme inducers. The partial clearance of antipyrine to the normetabolite was significantly increased by both inducers, whereas the rate of 4-hydroxylation was significantly increased only by prior antipyrine administration. The results indicate that the hydroxylation of metronidazole is not inhibited by cimetidine, but that it is inducible by phenobarbitone or antipyrine. It is suggested that metronidazole and antipyrine are metabolized by different enzymatic pathways. More... »

PAGES

35-41

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00609955

DOI

http://dx.doi.org/10.1007/bf00609955

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025190809

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3582467


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