Pharmakokinetic properties of noscapine View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-08

AUTHORS

B. Dahlström, T. Mellstrand, C. -G. Löfdahl, M. Johansson

ABSTRACT

Noscapine was administered to five healthy volunteers in a randomized crossover design, as an intravenous infusion of 66 mg, and as an oral 150 mg dose of either rapidly dissolving tablets or a tablet containing ion exchange resin-bound noscapine. After i.v. administration, the disposition of noscapine was bi-exponential with an elimination half-life of 2.6 h; the total plasma clearance was 22 ml/min/kg and the volume of distribution (Vdarea) was 4.7 l/kg. The absolute oral bioavailability was 30%, with a 3.6-fold interindividual variation. There was no pharmacokinetic evidence to support a prolonged action of the ion exchange resin tablet. More... »

PAGES

535-539

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00609627

DOI

http://dx.doi.org/10.1007/bf00609627

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030999507

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7128665


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