1982-08
AUTHORSB. Dahlström, T. Mellstrand, C. -G. Löfdahl, M. Johansson
ABSTRACTNoscapine was administered to five healthy volunteers in a randomized crossover design, as an intravenous infusion of 66 mg, and as an oral 150 mg dose of either rapidly dissolving tablets or a tablet containing ion exchange resin-bound noscapine. After i.v. administration, the disposition of noscapine was bi-exponential with an elimination half-life of 2.6 h; the total plasma clearance was 22 ml/min/kg and the volume of distribution (Vdarea) was 4.7 l/kg. The absolute oral bioavailability was 30%, with a 3.6-fold interindividual variation. There was no pharmacokinetic evidence to support a prolonged action of the ion exchange resin tablet. More... »
PAGES535-539
http://scigraph.springernature.com/pub.10.1007/bf00609627
DOIhttp://dx.doi.org/10.1007/bf00609627
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