Effects of adrenaline on membrane inward currents during the cardiac action potential View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1969-03

AUTHORS

G. Vassort, O. Rougier, D. Garnier, M. P. Sauviat, E. Coraboeuf, Y. M. Gargouïl

ABSTRACT

The effects of adrenaline on the inward currents flowing through the cardiac membranes were investigated in trabeculae of frog atria, by voltage clamp experiments. TTX was used as an inhibitor of the fast sodium channel and Mn as an inhibitor of a slow calcium-sodium channel.The fact that adrenaline increases the amplitude of the plateau of the cardiac action potentials has been confirmed. This substance does not appreciably modify the current flowing through the fast channel but considerably increases the inward current which, according to previous investigations, is carried by Ca++ and Na+. For this reason, adrenaline can be considered as an activator of the slow channel. The increase of an inward calcium current by adrenaline can partly explain the positive inotropic effect of the substance.Besides increasing the amplitude of the slow response, adrenaline decreases its threshold. This effect can explain that adrenaline is able to restore impaired conduction due to the action of TTX on fast sodium channel, as other workers observed. More... »

PAGES

70-81

References to SciGraph publications

  • 1967-12. Besitzen die sympathischen Überträgerstoffe einen direkten Einfluß auf die Leitungsgeschwindigkeit des Säugetiermyokards? in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1963-01. Increase of Sodium Efflux induced by Epinephrine in the Heart of the Frog in NATURE
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  • 1967-09. Effects of Norepinephrine on Tissues of the Frog Heart Atrium poisoned by Tetrodotoxin in NATURE
  • 1968-06. Voltage clamp experiments on frog atrial heart muscle fibres with the sucrose gap technique in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1960-03. Inotrope Effekte von ATP und Adrenalin am hypodynamen Froschmyokard nach elektro-mechanischer Entkoppelung durch Ca++-Entzug in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1957-05. Calcium and the Contraction of the Heart: Antagonism between Calcium and Sodium Ions in NATURE
  • 1965-01. Über die Wirkung von Adrenalin auf den cellulären Ca-Umsatz des Meerschweinchenvorhofs in NAUNYN SCHMIEDEBERG ARCH EXP PATH
  • 1959-04. Effect of increasing the calcium concentration during a single heart-beat in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 1966-12. Strom-Spannungsbeziehungen von Purkinje-Fasern bei verschiedenen extracellulären Calcium-Konzentrationen und unter Adrenalineinwirkung in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1965-09. Nachweis von zwei Komponenten in der Anstiegsphase des Aktionspotentials von Froschmyokardfasern in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1969-06. Existence and role of a slow inward current during the frog atrial action potential in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1961-03. Die Restitution der Erregungsfortleitung und Kontraktionskraft des K+-gelähmten Frosch- und Säugetiermyokards durch Adrenalin in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1960-01. Zur Membranwirkung des Adrenalins an der Herzmuskelfaser in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1958-09. Die Wirkung von Adrenalin auf Purkinje-Fasern von Säugetierherzen in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00592283

    DOI

    http://dx.doi.org/10.1007/bf00592283

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1046288796

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/5815320


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