Properties of the outward currents in frog atrial muscle View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1971-12

AUTHORS

A. de Hemptinne

ABSTRACT

The technique of the double sucrose gap was used to perform voltage clamp experiments on small segments of isolated auricular trabeculae of the frog heart. The voltage dependence and kinetics of the delayed rectification current were analyzed. The total outward current could be dissociated into two components: one component is defined as leakage current (Il) and shows inward rectification; a second component is the delayed rectification current (IK). The activation ofIKcan be described by a Hodgkin and Huxley type of kinetical model. The rate constants are found to be smaller by a factor of about 103 than those described in the giant axon of the squid.The results are used to compute the activation of the delayed rectification current and the total outward current during a normal action potential. More... »

PAGES

321-331

References to SciGraph publications

  • 1969-06. Existence and role of a slow inward current during the frog atrial action potential in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1968-06. Voltage clamp experiments on frog atrial heart muscle fibres with the sucrose gap technique in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00588003

    DOI

    http://dx.doi.org/10.1007/bf00588003

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/5316323


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