Kinetics of Na inactivation in frog atria View Full Text


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Article Info

DATE

1971-06

AUTHORS

H. G. Haas, R. Kern, H. M. Einwächter, M. Tarr

ABSTRACT

In frog atria, time and voltage dependence of inactivation and reactivation of fast transient Na current were studied using the sucrose-gap voltage clamp technique. Experiments were done at 4–7° C.Fast inward current inactivated by conditioning depolarizing clamps. The relation between steady-state inactivation and membrane potential is represented by an S-shaped curve similar to that observed in squid axon. At the resting level the availability of the Na-carrying system is about 60–70%.During depolarizing clamps inactivation of Na current follows an approximately exponential time course with time constants between 1.5 and 8 msec.Recovery from inactivation (reactivation) is much slower than development of inactivation. Time constants between 100 and 600 msec were observed during the recovery process following a repolarization or a hyperpolarization.A ratio between the time constants of inactivation and reactivation in the order of 1∶50 was found when the two processes were studied at the same potential level.In the frog atrial action potential the slow reactivation of the Na system is reflected by a relative refractory period reaching far beyond full repolarization.Assuming that the slow course of Na reactivation is an inherent feature of Na kinetics, the inactivation variable (h) of the Hodgkin-Huxley theory (1952d) seems inadequate to describe the inactivation-reactivation process in frog atria. Formally fast inactivation and slow reactivation could be accounted for by replacing the variableh with two variables which both decrease on depolarization but largely differ in the rate constants. More... »

PAGES

141-157

References to SciGraph publications

  • 1970-06. Voltage and time dependence of excitatory sodium current in cooled sheep Purkinje fibres in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1969-01. Two components of inward current in myocardial muscle fibers in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1968-06. Voltage clamp experiments on frog atrial heart muscle fibres with the sucrose gap technique in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1970-12. Electrical activity and metabolism in cardiac tissue: An experimental and theoretical study in THE JOURNAL OF MEMBRANE BIOLOGY
  • 1966-09. Excitatory membrane current in heart muscle (Purkinje fibers) in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1965-09. Nachweis von zwei Komponenten in der Anstiegsphase des Aktionspotentials von Froschmyokardfasern in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1969-06. Existence and role of a slow inward current during the frog atrial action potential in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00586445

    DOI

    http://dx.doi.org/10.1007/bf00586445

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031535848

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/5101235


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