Epinephrine and the pacemaking mechanisms at plateau potentials in sheep cardiac Purkinje fibers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1979-10

AUTHORS

Achilles J. Pappano, Edward E. Carmeliet

ABSTRACT

In 1.35 mM [K+]o, sheep cardiac Purkinje fibers depolarized to about −40 mV. Whereas some fibers oscillated spontaneously at plateau potentials, others could be made to oscillate when polarized by intracellular currents. Pacemaker activity at plateau potentials (−50 to 0 mV) was distinct from that caused by the\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document} $$i_{{\text{K}}_2 }$$ \end{document} pacemaker at more negative potentials (−60 to −100 mV).Epinephrine induced spontaneously occurring action potentials and increased pacemaker activity in depolarized Purkinje fibers. The ED50 for the positive chronotropic effect of epinephrine was about 5×10−7 M. This concentration is similar to that reported for the effect of epinephrine on plateau amplitude (Carmeliet and Vereecke, 1969) and the slow inward current (isi, Reuter, 1974).In voltage clamp experiments, epinephrine increased the magnitude ofisi and of an outward plateau current,ixi. It is concluded that epinephrine effects pacemaking at plateau potentials by increasingisi and without shifting the voltage dependence of these currents. The onset of pacemaker activity by epinephrine was preceded by membrane depolarization that results from an inward shift of the steady-state current-voltage relation. This current may flow throughisi channels that are activated but not completely inactivated. More... »

PAGES

17-26

References to SciGraph publications

  • 1967-12. The potassium component of membrane current in Purkinje fibers in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1977-01. Cardiac Purkinje fibres in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1977-10. Role of intracellular calcium in the transient outward current of calf Purkinje fibres in NATURE
  • 1969-12. Adrenaline and the plateau phase of the cardiac action potential in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1972-12. Cyclic AMP Mediates the Effects of Adrenaline on Cardiac Purkinje Fibres in NATURE
  • 1969-06. Existence and role of a slow inward current during the frog atrial action potential in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1964-03. Voltage clamp technique in mammalian cardiac fibres in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00585899

    DOI

    http://dx.doi.org/10.1007/bf00585899

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1029665267

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/574937


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