Kinetics of inactivation and recovery of the slow inward current in the mammalian ventricular myocardium View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1975-03

AUTHORS

M. Kohlhardt, H. Krause, M. Kübler, A. Herdey

ABSTRACT

In order to study the kinetics of inactivation and recovery of the slow inward current in the mammalian ventricular myocardium voltage clamp experiments using the double sucrose gap technique were performed on isolated trabeculae and papillary muscles of cats. The separation of the slow inward current from the fast Na current was achieved by use of the conditioning clamp procedure.The decay of the Ca current reflects the inactivation which develops due to depolarization. The rate of inactivation depends upon the membrane potential. Excess Ca (8.8 mM) accelerates the inactivation speed indicating that Ca ions not only act as charge carrier of the slow inward current but might influence in addition the kinetics of the slow membrane channel. In the presence of a lowered temperature a deceleration of inactivation (Q10 2.3) occurs.If the membrane is repolarized a recovery process takes place restoring the availability of the slow membrane channel. As the inactivation the recovery rate depends upon the membrane potential. Excess Ca causes an acceleration whereas a decrease in temperature diminishes the recovery speed (Q10 2.3). Consequently, the Ca supply to the myocardial cell can be modified not only by changes of the transmembrane Ca concentration gradient or by an alteration of the Ca conductance of the slow channel but also by changes in the degree of recovery after a preceding Ca current.Compared with the inactivation the recovery proceeds very slowly. Assuming that this slow recovery represents an inherent kinetic feature of the slow channel the kinetics of inactivation and removal of inactivation are not describable by a single inactivation variable (called as/by Reuter, 1973) which is of the Hodgkin-Huxley type. If a second inactivation variable (called asl) would be introduced additionally a formulation of the inactivation-recovery process of the slow membrane channel on the basis of the Hodgkin-Huxley model becomes feasible. More... »

PAGES

1-17

References to SciGraph publications

  • 1972-12. Differentiation of the transmembrane Na and Ca channels in mammalian cardiac fibres by the use of specific inhibitors in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1972-09. Electrical responses of cardiac muscle in Na-free high-Ca solution in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 1969-01. Two components of inward current in myocardial muscle fibers in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1953-05. Der Einfluß der Temperatur auf den Aktionsstrom des excidierten Purkinje-Fadens, gemessen mit einer intracellulären Elektrode in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1965-03. Die Bedeutung der Aktionspotential-Dauer und der Ca++-Ionen beim Zustandekommen der positiv-inotropen Kältewirkungen am Warmblüter-Myokard in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1970-12. Electrical activity and metabolism in cardiac tissue: An experimental and theoretical study in THE JOURNAL OF MEMBRANE BIOLOGY
  • 1971-09. Slow inward current and action potential in cardiac Purkinje fibres in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1966-12. Strom-Spannungsbeziehungen von Purkinje-Fasern bei verschiedenen extracellulären Calcium-Konzentrationen und unter Adrenalineinwirkung in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1971-06. Kinetics of Na inactivation in frog atria in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1972-03. Inward membrane currents in mammalian myocardium in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1970-03. The slow inward current and the action of manganese ions in guinea-pig's myocardium in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1970-12. Electrical and mechanical responses from ventricular muscle fibers after inactivation of the sodium carrying system in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1969-06. Existence and role of a slow inward current during the frog atrial action potential in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1972-09. Membrane potential and slow inward current dependence of frog cardiac mechanical activity in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00584795

    DOI

    http://dx.doi.org/10.1007/bf00584795

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021673807

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1171426


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0606", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Physiology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1106", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Human Movement and Sports Science", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Physiology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Action Potentials", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Calcium", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cats", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heart", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heart Ventricles", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kinetics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Membrane Potentials", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Myocardium", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Papillary Muscles", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sodium", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Temperature", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Time Factors", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Physiologisches Institut der Universit\u00e4t, Freiburg, Germany", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Physiologisches Institut der Universit\u00e4t, Freiburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kohlhardt", 
            "givenName": "M.", 
            "id": "sg:person.01105077361.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105077361.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Physiologisches Institut der Universit\u00e4t, Freiburg, Germany", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Physiologisches Institut der Universit\u00e4t, Freiburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Krause", 
            "givenName": "H.", 
            "id": "sg:person.054774340.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.054774340.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Physiologisches Institut der Universit\u00e4t, Freiburg, Germany", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Physiologisches Institut der Universit\u00e4t, Freiburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "K\u00fcbler", 
            "givenName": "M.", 
            "id": "sg:person.065555005.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.065555005.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Physiologisches Institut der Universit\u00e4t, Freiburg, Germany", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Physiologisches Institut der Universit\u00e4t, Freiburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Herdey", 
            "givenName": "A.", 
            "id": "sg:person.071323463.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.071323463.45"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/bf00585997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000107817", 
              "https://doi.org/10.1007/bf00585997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00586584", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033737114", 
              "https://doi.org/10.1007/bf00586584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00362492", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003173593", 
              "https://doi.org/10.1007/bf00362492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01868015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010604945", 
              "https://doi.org/10.1007/bf01868015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00586221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047748458", 
              "https://doi.org/10.1007/bf00586221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00589126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019359531", 
              "https://doi.org/10.1007/bf00589126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00592084", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051667322", 
              "https://doi.org/10.1007/bf00592084"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00363463", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023859066", 
              "https://doi.org/10.1007/bf00363463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00587018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011512209", 
              "https://doi.org/10.1007/bf00587018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01918668", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001551142", 
              "https://doi.org/10.1007/bf01918668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00586445", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031535848", 
              "https://doi.org/10.1007/bf00586445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00586384", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017201410", 
              "https://doi.org/10.1007/bf00586384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00587898", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002910314", 
              "https://doi.org/10.1007/bf00587898"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00363250", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036778574", 
              "https://doi.org/10.1007/bf00363250"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1975-03", 
        "datePublishedReg": "1975-03-01", 
        "description": "In order to study the kinetics of inactivation and recovery of the slow inward current in the mammalian ventricular myocardium voltage clamp experiments using the double sucrose gap technique were performed on isolated trabeculae and papillary muscles of cats. The separation of the slow inward current from the fast Na current was achieved by use of the conditioning clamp procedure.The decay of the Ca current reflects the inactivation which develops due to depolarization. The rate of inactivation depends upon the membrane potential. Excess Ca (8.8 mM) accelerates the inactivation speed indicating that Ca ions not only act as charge carrier of the slow inward current but might influence in addition the kinetics of the slow membrane channel. In the presence of a lowered temperature a deceleration of inactivation (Q10 2.3) occurs.If the membrane is repolarized a recovery process takes place restoring the availability of the slow membrane channel. As the inactivation the recovery rate depends upon the membrane potential. Excess Ca causes an acceleration whereas a decrease in temperature diminishes the recovery speed (Q10 2.3). Consequently, the Ca supply to the myocardial cell can be modified not only by changes of the transmembrane Ca concentration gradient or by an alteration of the Ca conductance of the slow channel but also by changes in the degree of recovery after a preceding Ca current.Compared with the inactivation the recovery proceeds very slowly. Assuming that this slow recovery represents an inherent kinetic feature of the slow channel the kinetics of inactivation and removal of inactivation are not describable by a single inactivation variable (called as/by Reuter, 1973) which is of the Hodgkin-Huxley type. If a second inactivation variable (called asl) would be introduced additionally a formulation of the inactivation-recovery process of the slow membrane channel on the basis of the Hodgkin-Huxley model becomes feasible.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/bf00584795", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1005222", 
            "issn": [
              "0031-6768", 
              "1432-2013"
            ], 
            "name": "Pfl\u00fcgers Archiv - European Journal of Physiology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "355"
          }
        ], 
        "keywords": [
          "membrane channels", 
          "membrane potential", 
          "kinetics of inactivation", 
          "Ca supply", 
          "inactivation", 
          "excess Ca", 
          "rate of inactivation", 
          "myocardial cells", 
          "clamp experiments", 
          "mammalian ventricular myocardium", 
          "membrane", 
          "cells", 
          "voltage-clamp experiments", 
          "concentration gradient", 
          "conductance", 
          "Ca", 
          "alterations", 
          "slow recovery", 
          "availability", 
          "potential", 
          "depolarization", 
          "changes", 
          "kinetics", 
          "channels", 
          "kinetic features", 
          "gradient", 
          "muscle", 
          "process", 
          "Ca conductance", 
          "Na current", 
          "presence", 
          "slow channels", 
          "Ca ions", 
          "basis", 
          "addition", 
          "types", 
          "Ca current", 
          "supply", 
          "experiments", 
          "clamp procedure", 
          "rate", 
          "ventricular myocardium", 
          "recovery", 
          "cats", 
          "decrease", 
          "degree of recovery", 
          "removal of inactivation", 
          "removal", 
          "features", 
          "isolated trabeculae", 
          "temperature", 
          "decay", 
          "degree", 
          "myocardium", 
          "trabeculae", 
          "recovery rate", 
          "carriers", 
          "recovery process", 
          "order", 
          "separation", 
          "use", 
          "ions", 
          "place", 
          "model", 
          "current", 
          "variables", 
          "technique", 
          "slow membrane channel", 
          "acceleration", 
          "procedure", 
          "speed", 
          "sucrose gap technique", 
          "fast Na current", 
          "deceleration", 
          "double sucrose gap technique", 
          "papillary muscles", 
          "inactivation variable", 
          "inactivation speed", 
          "formulation", 
          "Hodgkin-Huxley model", 
          "gap technique", 
          "Hodgkin-Huxley type", 
          "recovery speed", 
          "charge carriers"
        ], 
        "name": "Kinetics of inactivation and recovery of the slow inward current in the mammalian ventricular myocardium", 
        "pagination": "1-17", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1021673807"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/bf00584795"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "1171426"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/bf00584795", 
          "https://app.dimensions.ai/details/publication/pub.1021673807"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-06-01T21:57", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_120.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/bf00584795"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00584795'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00584795'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00584795'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00584795'


     

    This table displays all metadata directly associated to this object as RDF triples.

    287 TRIPLES      22 PREDICATES      141 URIs      116 LITERALS      20 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/bf00584795 schema:about N3b4fcb405d3f44768114c745bd3b39f1
    2 N3fec4751f15b4aa5a80a5fa77fc004a8
    3 N58e688dd31fd448d8616b0f56bc25324
    4 N5e9044c794f94f51ae4da37e774c3e7b
    5 N750393dfe5564ff3bbcd8b0bf6799704
    6 N9f04caf144ef48ef93f7e1610ecec917
    7 Na5c839ea56eb4fcbb0ca3315a71f814b
    8 Nbeaff81dbc1f49aeb25d4c4418a25531
    9 Nd449503597c848a79ffbe344ecf5b89b
    10 Nda346b51ba5c429db48f83307fd53c4b
    11 Ndb8d42077c5b445f9b5c220040c218ef
    12 Ne58eddd6909a4f83b092ee02d500bd80
    13 Nff1634ae47be40d18acbcacc514f31b6
    14 anzsrc-for:06
    15 anzsrc-for:0606
    16 anzsrc-for:11
    17 anzsrc-for:1106
    18 anzsrc-for:1116
    19 schema:author N792523aa1c3442c38ff8b008f68c9071
    20 schema:citation sg:pub.10.1007/bf00362492
    21 sg:pub.10.1007/bf00363250
    22 sg:pub.10.1007/bf00363463
    23 sg:pub.10.1007/bf00585997
    24 sg:pub.10.1007/bf00586221
    25 sg:pub.10.1007/bf00586384
    26 sg:pub.10.1007/bf00586445
    27 sg:pub.10.1007/bf00586584
    28 sg:pub.10.1007/bf00587018
    29 sg:pub.10.1007/bf00587898
    30 sg:pub.10.1007/bf00589126
    31 sg:pub.10.1007/bf00592084
    32 sg:pub.10.1007/bf01868015
    33 sg:pub.10.1007/bf01918668
    34 schema:datePublished 1975-03
    35 schema:datePublishedReg 1975-03-01
    36 schema:description In order to study the kinetics of inactivation and recovery of the slow inward current in the mammalian ventricular myocardium voltage clamp experiments using the double sucrose gap technique were performed on isolated trabeculae and papillary muscles of cats. The separation of the slow inward current from the fast Na current was achieved by use of the conditioning clamp procedure.The decay of the Ca current reflects the inactivation which develops due to depolarization. The rate of inactivation depends upon the membrane potential. Excess Ca (8.8 mM) accelerates the inactivation speed indicating that Ca ions not only act as charge carrier of the slow inward current but might influence in addition the kinetics of the slow membrane channel. In the presence of a lowered temperature a deceleration of inactivation (Q10 2.3) occurs.If the membrane is repolarized a recovery process takes place restoring the availability of the slow membrane channel. As the inactivation the recovery rate depends upon the membrane potential. Excess Ca causes an acceleration whereas a decrease in temperature diminishes the recovery speed (Q10 2.3). Consequently, the Ca supply to the myocardial cell can be modified not only by changes of the transmembrane Ca concentration gradient or by an alteration of the Ca conductance of the slow channel but also by changes in the degree of recovery after a preceding Ca current.Compared with the inactivation the recovery proceeds very slowly. Assuming that this slow recovery represents an inherent kinetic feature of the slow channel the kinetics of inactivation and removal of inactivation are not describable by a single inactivation variable (called as/by Reuter, 1973) which is of the Hodgkin-Huxley type. If a second inactivation variable (called asl) would be introduced additionally a formulation of the inactivation-recovery process of the slow membrane channel on the basis of the Hodgkin-Huxley model becomes feasible.
    37 schema:genre article
    38 schema:inLanguage en
    39 schema:isAccessibleForFree false
    40 schema:isPartOf N87471e406ed547e7bbc117c13f3dcb28
    41 Nf3ae3621a99a4f0ea4d6774b7f09de6a
    42 sg:journal.1005222
    43 schema:keywords Ca
    44 Ca conductance
    45 Ca current
    46 Ca ions
    47 Ca supply
    48 Hodgkin-Huxley model
    49 Hodgkin-Huxley type
    50 Na current
    51 acceleration
    52 addition
    53 alterations
    54 availability
    55 basis
    56 carriers
    57 cats
    58 cells
    59 changes
    60 channels
    61 charge carriers
    62 clamp experiments
    63 clamp procedure
    64 concentration gradient
    65 conductance
    66 current
    67 decay
    68 deceleration
    69 decrease
    70 degree
    71 degree of recovery
    72 depolarization
    73 double sucrose gap technique
    74 excess Ca
    75 experiments
    76 fast Na current
    77 features
    78 formulation
    79 gap technique
    80 gradient
    81 inactivation
    82 inactivation speed
    83 inactivation variable
    84 ions
    85 isolated trabeculae
    86 kinetic features
    87 kinetics
    88 kinetics of inactivation
    89 mammalian ventricular myocardium
    90 membrane
    91 membrane channels
    92 membrane potential
    93 model
    94 muscle
    95 myocardial cells
    96 myocardium
    97 order
    98 papillary muscles
    99 place
    100 potential
    101 presence
    102 procedure
    103 process
    104 rate
    105 rate of inactivation
    106 recovery
    107 recovery process
    108 recovery rate
    109 recovery speed
    110 removal
    111 removal of inactivation
    112 separation
    113 slow channels
    114 slow membrane channel
    115 slow recovery
    116 speed
    117 sucrose gap technique
    118 supply
    119 technique
    120 temperature
    121 trabeculae
    122 types
    123 use
    124 variables
    125 ventricular myocardium
    126 voltage-clamp experiments
    127 schema:name Kinetics of inactivation and recovery of the slow inward current in the mammalian ventricular myocardium
    128 schema:pagination 1-17
    129 schema:productId N6fecd9823957490a911c05e0773beeb2
    130 Ned8cc11ecb154aff9b3876a41e8cfc76
    131 Nf03d55e96a73476f9518286e642767b0
    132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021673807
    133 https://doi.org/10.1007/bf00584795
    134 schema:sdDatePublished 2022-06-01T21:57
    135 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    136 schema:sdPublisher Nb371e73566a74ea7b2eb6bbdcbbc0422
    137 schema:url https://doi.org/10.1007/bf00584795
    138 sgo:license sg:explorer/license/
    139 sgo:sdDataset articles
    140 rdf:type schema:ScholarlyArticle
    141 N3b4fcb405d3f44768114c745bd3b39f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Membrane Potentials
    143 rdf:type schema:DefinedTerm
    144 N3fec4751f15b4aa5a80a5fa77fc004a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Myocardium
    146 rdf:type schema:DefinedTerm
    147 N4adacbfa6f964f0da0fb0b318b57ed7b rdf:first sg:person.071323463.45
    148 rdf:rest rdf:nil
    149 N58e688dd31fd448d8616b0f56bc25324 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Kinetics
    151 rdf:type schema:DefinedTerm
    152 N5e9044c794f94f51ae4da37e774c3e7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Temperature
    154 rdf:type schema:DefinedTerm
    155 N6fecd9823957490a911c05e0773beeb2 schema:name pubmed_id
    156 schema:value 1171426
    157 rdf:type schema:PropertyValue
    158 N750393dfe5564ff3bbcd8b0bf6799704 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Heart
    160 rdf:type schema:DefinedTerm
    161 N792523aa1c3442c38ff8b008f68c9071 rdf:first sg:person.01105077361.36
    162 rdf:rest Ndbe8a950426f4ef8b330ea7cd8a302f8
    163 N87471e406ed547e7bbc117c13f3dcb28 schema:volumeNumber 355
    164 rdf:type schema:PublicationVolume
    165 N936e2d0d27f0426bbf0f2708ef20d196 rdf:first sg:person.065555005.34
    166 rdf:rest N4adacbfa6f964f0da0fb0b318b57ed7b
    167 N9f04caf144ef48ef93f7e1610ecec917 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Animals
    169 rdf:type schema:DefinedTerm
    170 Na5c839ea56eb4fcbb0ca3315a71f814b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Time Factors
    172 rdf:type schema:DefinedTerm
    173 Nb371e73566a74ea7b2eb6bbdcbbc0422 schema:name Springer Nature - SN SciGraph project
    174 rdf:type schema:Organization
    175 Nbeaff81dbc1f49aeb25d4c4418a25531 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Calcium
    177 rdf:type schema:DefinedTerm
    178 Nd449503597c848a79ffbe344ecf5b89b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Cats
    180 rdf:type schema:DefinedTerm
    181 Nda346b51ba5c429db48f83307fd53c4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Action Potentials
    183 rdf:type schema:DefinedTerm
    184 Ndb8d42077c5b445f9b5c220040c218ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Papillary Muscles
    186 rdf:type schema:DefinedTerm
    187 Ndbe8a950426f4ef8b330ea7cd8a302f8 rdf:first sg:person.054774340.04
    188 rdf:rest N936e2d0d27f0426bbf0f2708ef20d196
    189 Ne58eddd6909a4f83b092ee02d500bd80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Heart Ventricles
    191 rdf:type schema:DefinedTerm
    192 Ned8cc11ecb154aff9b3876a41e8cfc76 schema:name doi
    193 schema:value 10.1007/bf00584795
    194 rdf:type schema:PropertyValue
    195 Nf03d55e96a73476f9518286e642767b0 schema:name dimensions_id
    196 schema:value pub.1021673807
    197 rdf:type schema:PropertyValue
    198 Nf3ae3621a99a4f0ea4d6774b7f09de6a schema:issueNumber 1
    199 rdf:type schema:PublicationIssue
    200 Nff1634ae47be40d18acbcacc514f31b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name Sodium
    202 rdf:type schema:DefinedTerm
    203 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    204 schema:name Biological Sciences
    205 rdf:type schema:DefinedTerm
    206 anzsrc-for:0606 schema:inDefinedTermSet anzsrc-for:
    207 schema:name Physiology
    208 rdf:type schema:DefinedTerm
    209 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    210 schema:name Medical and Health Sciences
    211 rdf:type schema:DefinedTerm
    212 anzsrc-for:1106 schema:inDefinedTermSet anzsrc-for:
    213 schema:name Human Movement and Sports Science
    214 rdf:type schema:DefinedTerm
    215 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
    216 schema:name Medical Physiology
    217 rdf:type schema:DefinedTerm
    218 sg:journal.1005222 schema:issn 0031-6768
    219 1432-2013
    220 schema:name Pflügers Archiv - European Journal of Physiology
    221 schema:publisher Springer Nature
    222 rdf:type schema:Periodical
    223 sg:person.01105077361.36 schema:affiliation grid-institutes:None
    224 schema:familyName Kohlhardt
    225 schema:givenName M.
    226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105077361.36
    227 rdf:type schema:Person
    228 sg:person.054774340.04 schema:affiliation grid-institutes:None
    229 schema:familyName Krause
    230 schema:givenName H.
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.054774340.04
    232 rdf:type schema:Person
    233 sg:person.065555005.34 schema:affiliation grid-institutes:None
    234 schema:familyName Kübler
    235 schema:givenName M.
    236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.065555005.34
    237 rdf:type schema:Person
    238 sg:person.071323463.45 schema:affiliation grid-institutes:None
    239 schema:familyName Herdey
    240 schema:givenName A.
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.071323463.45
    242 rdf:type schema:Person
    243 sg:pub.10.1007/bf00362492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003173593
    244 https://doi.org/10.1007/bf00362492
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1007/bf00363250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036778574
    247 https://doi.org/10.1007/bf00363250
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1007/bf00363463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023859066
    250 https://doi.org/10.1007/bf00363463
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1007/bf00585997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000107817
    253 https://doi.org/10.1007/bf00585997
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1007/bf00586221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047748458
    256 https://doi.org/10.1007/bf00586221
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1007/bf00586384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017201410
    259 https://doi.org/10.1007/bf00586384
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1007/bf00586445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031535848
    262 https://doi.org/10.1007/bf00586445
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1007/bf00586584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033737114
    265 https://doi.org/10.1007/bf00586584
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1007/bf00587018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011512209
    268 https://doi.org/10.1007/bf00587018
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1007/bf00587898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002910314
    271 https://doi.org/10.1007/bf00587898
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1007/bf00589126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019359531
    274 https://doi.org/10.1007/bf00589126
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1007/bf00592084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051667322
    277 https://doi.org/10.1007/bf00592084
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1007/bf01868015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010604945
    280 https://doi.org/10.1007/bf01868015
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1007/bf01918668 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001551142
    283 https://doi.org/10.1007/bf01918668
    284 rdf:type schema:CreativeWork
    285 grid-institutes:None schema:alternateName Physiologisches Institut der Universität, Freiburg, Germany
    286 schema:name Physiologisches Institut der Universität, Freiburg, Germany
    287 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...