Inward current activated during hyperpolarization in the rabbit sinoatrial node cell View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1980-05

AUTHORS

K. Yanagihara, H. Irisawa

ABSTRACT

Inward current activated by hyperpolarizationih) was dissected from the K-current by the difference in its activation voltage range and the selective blocking effect of Ba2+ on the K-current. Theih shows little specificity to any particular ion, and its reversal potential was −25 mV. The current system can be expressed well by Hodgkin-Huxley type kinetics. The time constant ofih ranged from 2–4 s at about −70 mV, but it became shorter at about −10 mV. Theih began to activate at −50 mV and fully saturated at about −100 mV. The fully activated current-voltage relation shows no rectifying property. Activation and deactivation time courses were fitted by a single exponential with the same time constant at a given membrane potential. Althoughih plays only a small role during the normal action potential in the isolated preparation, it plays a significant role in keeping the pacemaker cell at a low membrane potential. More... »

PAGES

11-19

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00583909

DOI

http://dx.doi.org/10.1007/bf00583909

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015978321

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7191093


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